Reviewed, UniProtKB/Swiss-Prot Q1IG69 (BETB_PSEE4)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	PSEEN0373

Organism

Pseudomonas entomophila (strain L48) [Complete proteome] [HAMAP]

Taxonomic identifier

384676 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_1000047047
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1IG69-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 6B6A6FCE4BD07CBB	FASTA	490	52,929
	10 20 30 40 50 60 MARFGTQKLY IDGAYVDAGS DATFEAINPA TGEVLAHVQR ATQADVEKAV ESAERGQKVW 70 80 90 100 110 120 AAMTAMQRSR ILRRAVDILR ERNDELAMLE TLDTGKSYSE TRYVDIVTGA DVLEYYAGLV 130 140 150 160 170 180 PAIEGEQIPL RESSFVYTRR EPLGVTVGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTTLKLAE IFTEAGLPNG VFNVLTGSGR EVGTWLTEHP RIEKVSFTGG TTTGKKVMAS 250 260 270 280 290 300 ASSSSLKEVT MELGGKSPLI ICDDADLDKA ADIAMMANFY SSGQVCTNGT RVFVPAAMKA 310 320 330 340 350 360 AFEAKIAERV ARIRAGNPED ENTNFGPLVS FQHMESVLSY IAKGKEEGAR VLCGGERLTA 370 380 390 400 410 420 GDFAKGAFVA PTVFTDCTDD MTIVKEEIFG PVMSILSYET EEEVIRRAND TEYGLAAGVC 430 440 450 460 470 480 TNDISRAHRI IHKLEAGICW INAWGESPAE MPVGGYKQSG VGRENGVSSL AQYTRIKSVQ 490 VELGGYNSVF

References

[1]

"Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila." Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F. Nat. Biotechnol. 24:673-679(2006) [PubMed: 16699499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CT573326 Genomic DNA. Translation: CAK13333.1.
RefSeq	YP_606150.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IG69.
Genome annotation databases
GeneID	4089377.
GenomeReviews	Gene locus PSEEN0373 in contig CT573326_GR.
KEGG	pen:PSEEN0373.
NMPDR	fig|384676.6.peg.326.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1IG69.
OMA	TLKEVTM.
Enzyme and pathway databases
BioCyc	PENT384676:PSEEN0373-MON.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_PSEE4

Accession

Primary (citable) accession number: Q1IG69

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 13, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)