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Q1IG69

- BETB_PSEE4

UniProt

Q1IG69 - BETB_PSEE4

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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene
betB, PSEEN0373
Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Potassium 1; via carbonyl oxygen By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei162 – 1621Charge relay system By similarity
Metal bindingi180 – 1801Potassium 1; via carbonyl oxygen By similarity
Binding sitei209 – 2091NAD/NADP; via amide nitrogen By similarity
Metal bindingi246 – 2461Potassium 2; via carbonyl oxygen By similarity
Sitei248 – 2481Seems to be a necessary countercharge to the potassium cations By similarity
Active sitei252 – 2521Proton acceptor By similarity
Binding sitei286 – 2861NAD/NADP By similarity
Binding sitei387 – 3871NAD/NADP By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Metal bindingi460 – 4601Potassium 2; via carbonyl oxygen By similarity
Active sitei464 – 4641Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADP By similarity
Nucleotide bindingi176 – 1794NAD/NADP By similarity
Nucleotide bindingi229 – 2346NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciPENT384676:GJB8-343-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:PSEEN0373
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000658: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotationPRO_1000047047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei286 – 2861Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi384676.PSEEN0373.

Structurei

3D structure databases

ProteinModelPortaliQ1IG69.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiRANDTTM.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IG69-1 [UniParc]FASTAAdd to Basket

« Hide

MARFGTQKLY IDGAYVDAGS DATFEAINPA TGEVLAHVQR ATQADVEKAV    50
ESAERGQKVW AAMTAMQRSR ILRRAVDILR ERNDELAMLE TLDTGKSYSE 100
TRYVDIVTGA DVLEYYAGLV PAIEGEQIPL RESSFVYTRR EPLGVTVGIG 150
AWNYPIQIAL WKSAPALAAG NAMIFKPSEV TSLTTLKLAE IFTEAGLPNG 200
VFNVLTGSGR EVGTWLTEHP RIEKVSFTGG TTTGKKVMAS ASSSSLKEVT 250
MELGGKSPLI ICDDADLDKA ADIAMMANFY SSGQVCTNGT RVFVPAAMKA 300
AFEAKIAERV ARIRAGNPED ENTNFGPLVS FQHMESVLSY IAKGKEEGAR 350
VLCGGERLTA GDFAKGAFVA PTVFTDCTDD MTIVKEEIFG PVMSILSYET 400
EEEVIRRAND TEYGLAAGVC TNDISRAHRI IHKLEAGICW INAWGESPAE 450
MPVGGYKQSG VGRENGVSSL AQYTRIKSVQ VELGGYNSVF 490
Length:490
Mass (Da):52,929
Last modified:June 13, 2006 - v1
Checksum:i6B6A6FCE4BD07CBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573326 Genomic DNA. Translation: CAK13333.1.
RefSeqiWP_011531793.1. NC_008027.1.
YP_606150.1. NC_008027.1.

Genome annotation databases

EnsemblBacteriaiCAK13333; CAK13333; PSEEN0373.
GeneIDi4089377.
KEGGipen:PSEEN0373.
PATRICi19858956. VBIPseEnt83862_0354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573326 Genomic DNA. Translation: CAK13333.1 .
RefSeqi WP_011531793.1. NC_008027.1.
YP_606150.1. NC_008027.1.

3D structure databases

ProteinModelPortali Q1IG69.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 384676.PSEEN0373.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK13333 ; CAK13333 ; PSEEN0373 .
GeneIDi 4089377.
KEGGi pen:PSEEN0373.
PATRICi 19858956. VBIPseEnt83862_0354.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi RANDTTM.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci PENT384676:GJB8-343-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
    Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
    Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L48.

Entry informationi

Entry nameiBETB_PSEE4
AccessioniPrimary (citable) accession number: Q1IG69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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