Reviewed, UniProtKB/Swiss-Prot Q1IG47 (PQQC_PSEE4)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	PSEEN0396

Organism

Pseudomonas entomophila (strain L48) [Complete proteome] [HAMAP]

Taxonomic identifier

384676 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP MF_00654
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_1000061673

Sequences

	Sequence		Length	Mass (Da)
	Q1IG47-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: B1DC0A7F51410E2D	FASTA	251	28,903
	10 20 30 40 50 60 MNDAAPMSPA EFEQALRAKG AFYHIHHPYH VAMYEGRATR EQIQGWVANR FYYQVNIPMK 70 80 90 100 110 120 DAAILANCPD REVRREWVQR LLDHDGAPGE DGGIEAWLRL GQAVGLDPDQ LRSQELVLPG 130 140 150 160 170 180 VRFAVDAYVN FARRASWQEA ASSSLTELFA PQIHQSRLDS WPQHYPWIDP AGYEYFRTRL 190 200 210 220 230 240 GQARRDVEHG LAITLAHYTT REGQARMLEI LQFKLDILWS MLDAMSMAYE LNRPPYHSVT 250 SERVWHKGIA L

References

[1]

"Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila." Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F. Nat. Biotechnol. 24:673-679(2006) [PubMed: 16699499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573326 Genomic DNA. Translation: CAK13355.1.
RefSeq	YP_606172.1.
3D structure databases
SMR	Q1IG47. Positions 7-246.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IG47.
Genome annotation databases
GeneID	4085678.
GenomeReviews	Gene locus PSEEN0396 in contig CT573326_GR.
KEGG	pen:PSEEN0396.
NMPDR	fig|384676.6.peg.348.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG5424.
HOGENOM	HBG288944.
OMA	DSWPQHY.
Enzyme and pathway databases
BioCyc	PENT384676:PSEEN0396-MONOMER.
Family and domain databases
HAMAP	MF_00654. PQQ_syn_PqqC. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_PSEE4

Accession

Primary (citable) accession number: Q1IG47

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 13, 2006
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)