ID   Q1IF79_PSEE4            Unreviewed;       505 AA.
AC   Q1IF79;
DT   13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2006, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   OrderedLocusNames=PSEEN0753 {ECO:0000313|EMBL:CAK13675.1};
OS   Pseudomonas entomophila (strain L48).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=384676 {ECO:0000313|EMBL:CAK13675.1, ECO:0000313|Proteomes:UP000000658};
RN   [1] {ECO:0000313|EMBL:CAK13675.1, ECO:0000313|Proteomes:UP000000658}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L48 {ECO:0000313|EMBL:CAK13675.1,
RC   ECO:0000313|Proteomes:UP000000658};
RX   PubMed=16699499; DOI=10.1038/nbt1212;
RA   Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C.,
RA   Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P.,
RA   Weissenbach J., Lemaitre B., Medigue C., Boccard F.;
RT   "Complete genome sequence of the entomopathogenic and metabolically
RT   versatile soil bacterium Pseudomonas entomophila.";
RL   Nat. Biotechnol. 24:673-679(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00006594}.
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DR   EMBL; CT573326; CAK13675.1; -; Genomic_DNA.
DR   RefSeq; WP_011532107.1; NC_008027.1.
DR   AlphaFoldDB; Q1IF79; -.
DR   STRING; 384676.PSEEN0753; -.
DR   REBASE; 12674; M.PenLORF753P.
DR   GeneID; 32804066; -.
DR   KEGG; pen:PSEEN0753; -.
DR   eggNOG; COG2189; Bacteria.
DR   HOGENOM; CLU_020164_1_1_6; -.
DR   OrthoDB; 9816043at2; -.
DR   Proteomes; UP000000658; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002941; DNA_methylase_N4/N6.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR002295; N4/N6-MTase_EcoPI_Mod-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR   PANTHER; PTHR13370:SF33; TYPE II METHYLTRANSFERASE M.MJAV; 1.
DR   Pfam; PF01555; N6_N4_Mtase; 1.
DR   PRINTS; PR00506; D21N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:CAK13675.1};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAK13675.1}.
FT   DOMAIN          61..352
FT                   /note="DNA methylase N-4/N-6"
FT                   /evidence="ECO:0000259|Pfam:PF01555"
FT   REGION          173..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  56676 MW;  9E7F9E6EA245D776 CRC64;
     MPLLSWFNRD ADLTRAALAP YRLLMPNADL SHGEADSPNM LIQGDNLDAL KALLPYYAGQ
     VKCVFIDPPY NTKSAFEQYD DNLEHSQWLS MMYPRLELIR ELLAPDGSLW VTLDDNEAHY
     FKVICDEIFG RPNFIASVIW QKIYSPKNSA RHFSVDHDYI FVYAKNAEKW VPNPMPRTEK
     QDKAYRNPDN DPRGPWKAGD LSARNYYGAG VYPITTPSGR VISGPPNGMY WRVSEDKLRQ
     LDEDNRIWWG KDGGNVPAIK RFLSEVKQGR VPQTFWPYEE VGHTQDAKKE VVAIFGDENF
     ATPKPEALMK RILEVATNPG DLVLDSFLGS GTTIAVAHKM GRQWIGIEVG AHAESHCQPR
     LARVVDGEQG GVSKSLNWTG GGGFRYYTLG VPVFDESGHI RDGISFEQLA AHVWFAETGT
     ARSAHADKSS LLGIHLGTAY YLLFNGILGD LTNTGGNVLT KRVYRALPEF DGQKVVYGEA
     CALAPELLQE LKITFRQTPY DIRAR
//