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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPENT384676:G1GI5-1284-MONOMER
UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:PSEEN1370
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000658 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000464591 – 352Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST352

Interactioni

Protein-protein interaction databases

STRINGi384676.PSEEN1370

Structurei

3D structure databases

ProteinModelPortaliQ1IDL2
SMRiQ1IDL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229090
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG091H0128

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.101 hit
3.90.650.101 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

Q1IDL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQPSLSYK DAGVDIDAGE ALVERIKGVA KRTARPEVMG GLGGFGALCE
60 70 80 90 100
IPAGYKQPVL VSGTDGVGTK LRLALNLNKH DSIGQDLVAM CVNDLVVCGA
110 120 130 140 150
EPLFFLDYYA TGKLNVDVAA TVVTGIGAGC ELAGCSLVGG ETAEMPGMYE
160 170 180 190 200
GEDYDLAGFC VGVVEKADII DGSKVVTGDA LIALPSSGPH SNGYSLIRKI
210 220 230 240 250
LEVSGTDIDN TQLDGKPLAD LLMAPTRIYV KPLLQLIKQT GAVKAMAHIT
260 270 280 290 300
GGGLLDNIPR VLPKNAQAVV DVASWQRPVV FDFLQEKGNV DEHEMHRVLN
310 320 330 340 350
CGVGMVICVA QDQVENALNV LRAEGEQPWV IGRIDVAAEG AAQVELHNLK

AH
Length:352
Mass (Da):37,054
Last modified:June 13, 2006 - v1
Checksum:iF7C1523E5722255D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA Translation: CAK14247.1
RefSeqiWP_011532663.1, NC_008027.1

Genome annotation databases

EnsemblBacteriaiCAK14247; CAK14247; PSEEN1370
GeneIDi32804634
KEGGipen:PSEEN1370

Similar proteinsi

Entry informationi

Entry nameiPUR5_PSEE4
AccessioniPrimary (citable) accession number: Q1IDL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome