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Protein

Catalase-peroxidase

Gene

katG

Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Transition state stabilizerUniRule annotation
Active sitei92 – 921Proton acceptorUniRule annotation
Metal bindingi282 – 2821Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPENT384676:GJB8-2248-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:PSEEN2372
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000658 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Catalase-peroxidasePRO_0000354862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki91 ↔ 241Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-267)UniRule annotation
Cross-linki241 ↔ 267Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ1IAY6.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi384676.PSEEN2372.

Structurei

3D structure databases

ProteinModelPortaliQ1IAY6.
SMRiQ1IAY6. Positions 16-743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IAY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANESKCPFH QTAGGGTSNR DWWPDQLNLK ILHQHSRKSD PMDPDFDYAK
60 70 80 90 100
AFKSLDFQAL KKDLTALMTD SQDWWPADFG HYGPLFIRMA WHSAGTYRIG
110 120 130 140 150
DGRGGAGSGQ QRFAPLNSWP DNVSLDKARR LLWPIKQKYG NKISWADLIV
160 170 180 190 200
LTGNVALESM GFKTFGFSGG RADVWEPDED VYWGSEKVWL GGDTRYGKAE
210 220 230 240 250
APGKGDLVAE PAKRPQEQGR NLAGERNLEN PLAAVQMGLI YVNPEGPEGN
260 270 280 290 300
PDPVASGKDI RDTFGRMAMN DEETVALIAG GHAFGKTHGA GPADNVGAEP
310 320 330 340 350
EAAGLEQQGF GWHNTFGTGK GGDTITSGLE VTWTSTPTKW SNEYLNNLFN
360 370 380 390 400
FEWELTKSPA GAHQWRPKDG KGANTVPDAH DTTKRHAPSM LTSDLALRFD
410 420 430 440 450
PIYEPIARRF KDNPDQLADA FARAWYKLIH RDMGPLARYL GPEMPNEELL
460 470 480 490 500
WQDPLPKAGP QPSEADIAAH KAKVLASGLS VAELVSTAWA SASTFRGSDK
510 520 530 540 550
RGGANGARLR LAPQKDWAAN QGLDKVLAAL EKIRDEGGNK ISLADLIVLA
560 570 580 590 600
GSAAVEKAAK DAGHAISVPF HPGRVDASQA QTDVESFAVL EPLADGFRNF
610 620 630 640 650
SKARYSVKAE KLLLDKAQLL TLTAPELTVL VGGLRVLGAN HGGSKEGVFT
660 670 680 690 700
DKPGVLTNDF FRNLLDMGVE WKPTSADNEH FEGRDRKTGA VKWTGSRVDL
710 720 730 740
VFGSHAQLRA LSEVYGSGDA AAKFVKDFVA AWVKVMELDR FDLK
Length:744
Mass (Da):81,082
Last modified:June 13, 2006 - v1
Checksum:i9A4B8DEE8CD189FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA. Translation: CAK15180.1.
RefSeqiWP_011533580.1. NC_008027.1.

Genome annotation databases

EnsemblBacteriaiCAK15180; CAK15180; PSEEN2372.
KEGGipen:PSEEN2372.
PATRICi19862880. VBIPseEnt83862_2267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA. Translation: CAK15180.1.
RefSeqiWP_011533580.1. NC_008027.1.

3D structure databases

ProteinModelPortaliQ1IAY6.
SMRiQ1IAY6. Positions 16-743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi384676.PSEEN2372.

Proteomic databases

PRIDEiQ1IAY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK15180; CAK15180; PSEEN2372.
KEGGipen:PSEEN2372.
PATRICi19862880. VBIPseEnt83862_2267.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciPENT384676:GJB8-2248-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
    Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
    Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L48.

Entry informationi

Entry nameiKATG_PSEE4
AccessioniPrimary (citable) accession number: Q1IAY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 13, 2006
Last modified: December 9, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.