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Q1I9H0

- UPPP_PSEE4

UniProt

Q1I9H0 - UPPP_PSEE4

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciPENT384676:GJB8-2781-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:PSEEN2933
    OrganismiPseudomonas entomophila (strain L48)
    Taxonomic identifieri384676 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000658: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Undecaprenyl-diphosphatasePRO_0000290752Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi384676.PSEEN2933.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalUniRule annotationAdd
    BLAST
    Transmembranei85 – 10521HelicalUniRule annotationAdd
    BLAST
    Transmembranei109 – 12921HelicalUniRule annotationAdd
    BLAST
    Transmembranei183 – 20321HelicalUniRule annotationAdd
    BLAST
    Transmembranei214 – 23421HelicalUniRule annotationAdd
    BLAST
    Transmembranei248 – 26821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1I9H0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFWSALQAI ILGVVEGLTE FLPISSTGHQ IIVADLINFG GERAMAFNII    50
    IQLGAILAVV WEFRRKIFDV VLGLPTQAPA RRFTANLLIA FFPAVVLGVL 100
    FADLIHEYLF NPITVAAALV VGGVIMLWAE RRQHRIEVDH VDEMSWHHAL 150
    KIGFVQCLAM IPGTSRSGST IIGGLLFGLS RKAATEFSFF LAMPTMVGAA 200
    VYSGYKYREL FQPGDLPVFA LGFVVSFIFA MIAVRGLLKF IANHSYAVFA 250
    WYRIAFGLLI LATWEFGWVD WSTAHG 276
    Length:276
    Mass (Da):30,544
    Last modified:June 13, 2006 - v1
    Checksum:i2F4DA8239A612C63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT573326 Genomic DNA. Translation: CAK15708.1.
    RefSeqiWP_011534096.1. NC_008027.1.
    YP_608499.1. NC_008027.1.

    Genome annotation databases

    EnsemblBacteriaiCAK15708; CAK15708; PSEEN2933.
    GeneIDi4085937.
    KEGGipen:PSEEN2933.
    PATRICi19863972. VBIPseEnt83862_2810.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT573326 Genomic DNA. Translation: CAK15708.1 .
    RefSeqi WP_011534096.1. NC_008027.1.
    YP_608499.1. NC_008027.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 384676.PSEEN2933.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK15708 ; CAK15708 ; PSEEN2933 .
    GeneIDi 4085937.
    KEGGi pen:PSEEN2933.
    PATRICi 19863972. VBIPseEnt83862_2810.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci PENT384676:GJB8-2781-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
      Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
      Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: L48.

    Entry informationi

    Entry nameiUPPP_PSEE4
    AccessioniPrimary (citable) accession number: Q1I9H0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3