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Protein

LexA repressor

Gene

lexA

Organism
Pseudomonas entomophila (strain L48)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei123For autocatalytic cleavage activityUniRule annotation1
Active sitei160For autocatalytic cleavage activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 48H-T-H motifUniRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotationImported, RepressorUniRule annotationSAAS annotation
Biological processDNA damage, DNA repairUniRule annotationSAAS annotation, DNA replicationUniRule annotationSAAS annotation, SOS responseUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPENT384676:G1GI5-3483-MONOMER

Protein family/group databases

MEROPSiS24.001

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotationImported
Ordered Locus Names:PSEEN3721Imported
OrganismiPseudomonas entomophila (strain L48)Imported
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000658 Componenti: Chromosome

PTM / Processingi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei88 – 89Cleavage; by autolysisUniRule annotation2

Keywords - PTMi

Autocatalytic cleavageUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi384676.PSEEN3721

Structurei

3D structure databases

ProteinModelPortaliQ1I7E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 65LexA_DNA_bindInterPro annotationAdd BLAST65
Domaini118 – 184Peptidase_S24InterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the peptidase S24 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DS7 Bacteria
COG1974 LUCA
HOGENOMiHOG000232167
KOiK01356
OMAiRQMMQAM
OrthoDBiPOG091H029U

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00015 LexA, 1 hit
InterProiView protein in InterPro
IPR001742 Capsid_VP2_Orbivir
IPR006200 LexA
IPR036286 LexA/Signal_pep-like_sf
IPR006199 LexA_DNA-bd_dom
IPR006197 Peptidase_S24_LexA
IPR015927 Peptidase_S24_S26A/B/C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01726 LexA_DNA_bind, 1 hit
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00726 LEXASERPTASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002938 Capsid_VP2_Orbivir, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR00498 lexA, 1 hit

Sequencei

Sequence statusi: Complete.

Q1I7E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLTPRQAE ILAFIKRCLE DNGFPPTRAE IAQELGFKSP NAAEEHLKAL
60 70 80 90 100
ARKGAIEMTP GASRGIRIPG VEAKVEDNGL PIIGRVAAGA PILAEQHIEE
110 120 130 140 150
SCNINPAFFH PRADYLLRVH GMSMKDIGIF DGDLLAVHTT REARNGQVVV
160 170 180 190 200
ARIGDEVTVK RFKREGSKVW LIAENPEFAP IEVDLKEQEL VIEGLSVGVL

RR
Length:202
Mass (Da):22,218
Last modified:June 13, 2006 - v1
Checksum:iB3617BBF94707B85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA Translation: CAK16441.1
RefSeqiWP_011534818.1, NC_008027.1

Genome annotation databases

EnsemblBacteriaiCAK16441; CAK16441; PSEEN3721
GeneIDi32806765
KEGGipen:PSEEN3721

Similar proteinsi

Entry informationi

Entry nameiQ1I7E1_PSEE4
AccessioniPrimary (citable) accession number: Q1I7E1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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