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Q1I7E1 (Q1I7E1_PSEE4) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
LexA repressor HAMAP-Rule MF_00015
EC=3.4.21.88 HAMAP-Rule MF_00015
Gene names
Name:lexA HAMAP-Rule MF_00015 EMBL CAK16441.1
Ordered Locus Names:PSEEN3721
OrganismPseudomonas entomophila (strain L48) [Complete proteome] [HAMAP]
Taxonomic identifier384676 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity. HAMAP-Rule MF_00015

Catalytic activity

Hydrolysis of Ala-|-Gly bond in repressor lexA. RuleBase RU003992 HAMAP-Rule MF_00015 SAAS SAAS019759

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00015 SAAS SAAS019759

Sequence similarities

Belongs to the peptidase S24 family. RuleBase RU003991 HAMAP-Rule MF_00015

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

DNA binding28 – 4821H-T-H motif By similarity HAMAP-Rule MF_00015

Sites

Active site1231For autocatalytic cleavage activity By similarity HAMAP-Rule MF_00015
Active site1601For autocatalytic cleavage activity By similarity HAMAP-Rule MF_00015
Site88 – 892Cleavage; by autolysis By similarity HAMAP-Rule MF_00015

Sequences

Sequence LengthMass (Da)Tools
Q1I7E1 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: B3617BBF94707B85

FASTA20222,218
        10         20         30         40         50         60 
MLKLTPRQAE ILAFIKRCLE DNGFPPTRAE IAQELGFKSP NAAEEHLKAL ARKGAIEMTP 

        70         80         90        100        110        120 
GASRGIRIPG VEAKVEDNGL PIIGRVAAGA PILAEQHIEE SCNINPAFFH PRADYLLRVH 

       130        140        150        160        170        180 
GMSMKDIGIF DGDLLAVHTT REARNGQVVV ARIGDEVTVK RFKREGSKVW LIAENPEFAP 

       190        200 
IEVDLKEQEL VIEGLSVGVL RR

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References

[1]"Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L48.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT573326 Genomic DNA. Translation: CAK16441.1.
RefSeqYP_609228.1. NC_008027.1.

3D structure databases

ProteinModelPortalQ1I7E1.
SMRQ1I7E1. Positions 4-201.
ModBaseSearch...

Protein-protein interaction databases

STRING384676.PSEEN3721.

Protein family/group databases

MEROPSS24.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK16441; CAK16441; PSEEN3721.
GeneID4088987.
KEGGpen:PSEEN3721.
PATRIC19865516. VBIPseEnt83862_3576.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1974.
HOGENOMHOG000232167.
KOK01356.
OMAIEGLGVG.
ProtClustDBPRK00215.

Enzyme and pathway databases

BioCycPENT384676:GJB8-3522-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPMF_00015. LexA.
InterProIPR001742. Capsid_VP2_Orbivir.
IPR006199. LexA_DNA-bd_dom.
IPR006200. Pept_S24_LexA.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011056. Peptidase_S24_S26A/B/C_b-rbn.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00726. LEXASERPTASE.
ProDomPD002938. Capsid_VP2_Orbivir. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF51306. Pept_S24_S26_C. 1 hit.
TIGRFAMsTIGR00498. lexA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ1I7E1_PSEE4
AccessionPrimary (citable) accession number: Q1I7E1
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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