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Q1I7E1

- Q1I7E1_PSEE4

UniProt

Q1I7E1 - Q1I7E1_PSEE4

Protein

LexA repressor

Gene

lexA

Organism
Pseudomonas entomophila (strain L48)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

    Catalytic activityi

    Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei88 – 892Cleavage; by autolysisUniRule annotation
    Active sitei123 – 1231For autocatalytic cleavage activityUniRule annotation
    Active sitei160 – 1601For autocatalytic cleavage activityUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi28 – 4821H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. serine-type endopeptidase activity Source: UniProtKB-HAMAP
    3. structural molecule activity Source: InterPro

    GO - Biological processi

    1. DNA repair Source: UniProtKB-HAMAP
    2. DNA replication Source: UniProtKB-HAMAP
    3. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    4. SOS response Source: UniProtKB-HAMAP
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotationImported, RepressorUniRule annotationSAAS annotation

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replicationUniRule annotationSAAS annotation, SOS responseUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPENT384676:GJB8-3522-MONOMER.

    Protein family/group databases

    MEROPSiS24.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
    Gene namesi
    Name:lexAUniRule annotationImported
    Ordered Locus Names:PSEEN3721Imported
    OrganismiPseudomonas entomophila (strain L48)Imported
    Taxonomic identifieri384676 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000658: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. viral capsid Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    Autocatalytic cleavageUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi384676.PSEEN3721.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1I7E1.
    SMRiQ1I7E1. Positions 4-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S24 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1974.
    HOGENOMiHOG000232167.
    KOiK01356.
    OMAiMSMKNIG.
    OrthoDBiEOG6JHRHJ.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.10.109.10. 1 hit.
    HAMAPiMF_00015. LexA.
    InterProiIPR001742. Capsid_VP2_Orbivir.
    IPR006200. LexA.
    IPR006199. LexA_DNA-bd_dom.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR006197. Peptidase_S24_LexA.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01726. LexA_DNA_bind. 1 hit.
    PF00717. Peptidase_S24. 1 hit.
    [Graphical view]
    PRINTSiPR00726. LEXASERPTASE.
    ProDomiPD002938. Capsid_VP2_Orbivir. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF51306. SSF51306. 1 hit.
    TIGRFAMsiTIGR00498. lexA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1I7E1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKLTPRQAE ILAFIKRCLE DNGFPPTRAE IAQELGFKSP NAAEEHLKAL    50
    ARKGAIEMTP GASRGIRIPG VEAKVEDNGL PIIGRVAAGA PILAEQHIEE 100
    SCNINPAFFH PRADYLLRVH GMSMKDIGIF DGDLLAVHTT REARNGQVVV 150
    ARIGDEVTVK RFKREGSKVW LIAENPEFAP IEVDLKEQEL VIEGLSVGVL 200
    RR 202
    Length:202
    Mass (Da):22,218
    Last modified:June 13, 2006 - v1
    Checksum:iB3617BBF94707B85
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT573326 Genomic DNA. Translation: CAK16441.1.
    RefSeqiWP_011534818.1. NC_008027.1.
    YP_609228.1. NC_008027.1.

    Genome annotation databases

    EnsemblBacteriaiCAK16441; CAK16441; PSEEN3721.
    GeneIDi4088987.
    KEGGipen:PSEEN3721.
    PATRICi19865516. VBIPseEnt83862_3576.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT573326 Genomic DNA. Translation: CAK16441.1 .
    RefSeqi WP_011534818.1. NC_008027.1.
    YP_609228.1. NC_008027.1.

    3D structure databases

    ProteinModelPortali Q1I7E1.
    SMRi Q1I7E1. Positions 4-201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 384676.PSEEN3721.

    Protein family/group databases

    MEROPSi S24.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK16441 ; CAK16441 ; PSEEN3721 .
    GeneIDi 4088987.
    KEGGi pen:PSEEN3721.
    PATRICi 19865516. VBIPseEnt83862_3576.

    Phylogenomic databases

    eggNOGi COG1974.
    HOGENOMi HOG000232167.
    KOi K01356.
    OMAi MSMKNIG.
    OrthoDBi EOG6JHRHJ.

    Enzyme and pathway databases

    BioCyci PENT384676:GJB8-3522-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.10.109.10. 1 hit.
    HAMAPi MF_00015. LexA.
    InterProi IPR001742. Capsid_VP2_Orbivir.
    IPR006200. LexA.
    IPR006199. LexA_DNA-bd_dom.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR006197. Peptidase_S24_LexA.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01726. LexA_DNA_bind. 1 hit.
    PF00717. Peptidase_S24. 1 hit.
    [Graphical view ]
    PRINTSi PR00726. LEXASERPTASE.
    ProDomi PD002938. Capsid_VP2_Orbivir. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF51306. SSF51306. 1 hit.
    TIGRFAMsi TIGR00498. lexA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
      Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
      Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: L48Imported.

    Entry informationi

    Entry nameiQ1I7E1_PSEE4
    AccessioniPrimary (citable) accession number: Q1I7E1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3