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Protein

Ribosomal RNA large subunit methyltransferase M

Gene

rlmM

Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183S-adenosyl-L-methionineUniRule annotation1
Binding sitei235S-adenosyl-L-methionineUniRule annotation1
Binding sitei255S-adenosyl-L-methionineUniRule annotation1
Binding sitei271S-adenosyl-L-methionineUniRule annotation1
Active sitei300Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)
Alternative name(s):
23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation
23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation
Gene namesi
Name:rlmMUniRule annotation
Ordered Locus Names:PSEEN3755
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000658 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003145261 – 354Ribosomal RNA large subunit methyltransferase MAdd BLAST354

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi384676.PSEEN3755.

Structurei

3D structure databases

ProteinModelPortaliQ1I7B1.
SMRiQ1I7B1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni216 – 219S-adenosyl-L-methionine bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiPVDWMVC.
OrthoDBiPOG091H04R8.

Family and domain databases

HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiView protein in InterPro
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01728. FtsJ. 1 hit.
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1I7B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLFMHCRP GFEGEVCAEI SEHAALLGVA GYAKGKPQSA CAEFVCTEPD
60 70 80 90 100
GAQRLMHELR FAQLIFPRQW ARGAFVELPE TDRISVLLEH LADLPVCGSL
110 120 130 140 150
WLEVLDSNEG KELSTFCRKF EVPLRKALEK AGRLVDDARR PRLLLTFISG
160 170 180 190 200
RRVFLGLAEA DNSALWPMGI PRLKFPREAP SRSTLKLEEA WHQFIPREQW
210 220 230 240 250
EQRLNDDMTG VDLGASPGGW TYQLVKRGML VTAIDNGPMA ESLMDTGLVT
260 270 280 290 300
HLMADGFTWK PKHTVDWMVC DIVEKPARTA SLIETWLGEG LCREAVVNLK
310 320 330 340 350
LPMKQRHAEV RKLLDRMEAG FKERKVKVSI ACKQLYHDRE EVTCHLRRLD

LKPH
Length:354
Mass (Da):40,179
Last modified:June 13, 2006 - v1
Checksum:i3297646F8945E006
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA. Translation: CAK16471.1.
RefSeqiWP_011534848.1. NC_008027.1.

Genome annotation databases

EnsemblBacteriaiCAK16471; CAK16471; PSEEN3755.
GeneIDi32806794.
KEGGipen:PSEEN3755.

Similar proteinsi

Entry informationi

Entry nameiRLMM_PSEE4
AccessioniPrimary (citable) accession number: Q1I7B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: August 30, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families