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Q1I639

- LPXB_PSEE4

UniProt

Q1I639 - LPXB_PSEE4

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, PSEEN4207
Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPENT384676:GJB8-3990-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:PSEEN4207
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000658: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Lipid-A-disaccharide synthaseUniRule annotationPRO_1000049409Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi384676.PSEEN4207.

Structurei

3D structure databases

ProteinModelPortaliQ1I639.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiEWTINPP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1I639-1 [UniParc]FASTAAdd to Basket

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MAQLCVALVA GEASGDILGS GLMRAIKARH PDVRFIGVGG PLMEAEGMSS    50
YFPMERLAVM GLVEVLGRLR ELLKRRKELI ATLIDEKPDV FIGIDAPDFT 100
LNIELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF 150
YEEQGVPVRF VGHPLADTIP LESDRGAARA ELGLAEGPVI ALMPGSRGGE 200
VGRLGALFLD AAQRLRELVP GVRFVLPCAN AARRAQVEQM LEGRDLPLTL 250
LDGRSHQALA ACDAVLIASG TATLEAMLYK RPMVVAYRLA PLTYWILKRM 300
VKSPYVSLPN LLAQRMLVPE LLQDAATSEA LAQTLAPLVG DGSQQTDSFD 350
QIHRTLRRDA SNQAADAVLA LLKDR 375
Length:375
Mass (Da):41,030
Last modified:June 13, 2006 - v1
Checksum:iBEDC327EF2A86F77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573326 Genomic DNA. Translation: CAK16896.1.
RefSeqiWP_011535267.1. NC_008027.1.
YP_609680.1. NC_008027.1.

Genome annotation databases

EnsemblBacteriaiCAK16896; CAK16896; PSEEN4207.
GeneIDi4089128.
KEGGipen:PSEEN4207.
PATRICi19866474. VBIPseEnt83862_4043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573326 Genomic DNA. Translation: CAK16896.1 .
RefSeqi WP_011535267.1. NC_008027.1.
YP_609680.1. NC_008027.1.

3D structure databases

ProteinModelPortali Q1I639.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 384676.PSEEN4207.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK16896 ; CAK16896 ; PSEEN4207 .
GeneIDi 4089128.
KEGGi pen:PSEEN4207.
PATRICi 19866474. VBIPseEnt83862_4043.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi EWTINPP.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PENT384676:GJB8-3990-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
    Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
    Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L48.

Entry informationi

Entry nameiLPXB_PSEE4
AccessioniPrimary (citable) accession number: Q1I639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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