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Q1I639 (LPXB_PSEE4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:PSEEN4207
OrganismPseudomonas entomophila (strain L48) [Complete proteome] [HAMAP]
Taxonomic identifier384676 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_1000049409

Sequences

Sequence LengthMass (Da)Tools
Q1I639 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: BEDC327EF2A86F77

FASTA37541,030
        10         20         30         40         50         60 
MAQLCVALVA GEASGDILGS GLMRAIKARH PDVRFIGVGG PLMEAEGMSS YFPMERLAVM 

        70         80         90        100        110        120 
GLVEVLGRLR ELLKRRKELI ATLIDEKPDV FIGIDAPDFT LNIELKLRQA GIKTVHYVSP 

       130        140        150        160        170        180 
SVWAWRQKRV LKIREGCDLM LTLLPFEARF YEEQGVPVRF VGHPLADTIP LESDRGAARA 

       190        200        210        220        230        240 
ELGLAEGPVI ALMPGSRGGE VGRLGALFLD AAQRLRELVP GVRFVLPCAN AARRAQVEQM 

       250        260        270        280        290        300 
LEGRDLPLTL LDGRSHQALA ACDAVLIASG TATLEAMLYK RPMVVAYRLA PLTYWILKRM 

       310        320        330        340        350        360 
VKSPYVSLPN LLAQRMLVPE LLQDAATSEA LAQTLAPLVG DGSQQTDSFD QIHRTLRRDA 

       370 
SNQAADAVLA LLKDR 

« Hide

References

[1]"Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L48.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT573326 Genomic DNA. Translation: CAK16896.1.
RefSeqYP_609680.1. NC_008027.1.

3D structure databases

ProteinModelPortalQ1I639.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING384676.PSEEN4207.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK16896; CAK16896; PSEEN4207.
GeneID4089128.
KEGGpen:PSEEN4207.
PATRIC19866474. VBIPseEnt83862_4043.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAEWTINPP.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycPENT384676:GJB8-3990-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_PSEE4
AccessionPrimary (citable) accession number: Q1I639
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways