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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homogentisate 1,2-dioxygenase (hmgA)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei288Proton acceptorUniRule annotation1
Metal bindingi331IronUniRule annotation1
Metal bindingi337IronUniRule annotation1
Binding sitei346homogentisateUniRule annotation1
Metal bindingi367IronUniRule annotation1
Binding sitei367homogentisateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciPENT384676:G1GI5-4338-MONOMER
UniPathwayiUPA00139; UER00339

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:PSEEN4612
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000658 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000195341 – 433Homogentisate 1,2-dioxygenaseAdd BLAST433

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi384676.PSEEN4612

Structurei

3D structure databases

SMRiQ1I500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F1J Bacteria
COG3508 LUCA
HOGENOMiHOG000139824
KOiK00451
OMAiHGNYTPY
OrthoDBiPOG091H04E0

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00334 Homogentis_dioxygen, 1 hit
InterProiView protein in InterPro
IPR005708 Homogentis_dOase
IPR022950 Homogentis_dOase_bac
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR11056 PTHR11056, 1 hit
PfamiView protein in Pfam
PF04209 HgmA, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR01015 hmgA, 1 hit

Sequencei

Sequence statusi: Complete.

Q1I500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRDTSPQLQ YLSGFGNEFA SEALPGALPV GQNSPQKAPY GLYAELLSGT
60 70 80 90 100
AFTMTRSELR RTWLYRIRPS ALHPRFERLE RQPLTGALGA ITPNRLRWSP
110 120 130 140 150
QPMPAEPTDF IEGWLPMVAN SASEKPAGVS IYIYRANRSM ERVFFNADGE
160 170 180 190 200
LLLVPEQGRL RIATELGVLE VEPLEIAVIP RGMKFRVELL DDQARGYIAE
210 220 230 240 250
NHGAPLRIPD LGPIGSNGLA NPRDFLTPVA HYEETSGPVQ LVQKFLGEHW
260 270 280 290 300
ACELQHSPLD VVAWHGSNVP YKYDLRRFNT IGTVSFDHPD PSIFTVLTSP
310 320 330 340 350
TSVHGMANMD FVIFPPRWMV AENTFRPPWF HRNLMNEFMG LIQGAYDAKA
360 370 380 390 400
EGFLPGGASL HGVMSAHGPD AETCDKAISV DLAPHKIDNT MAFMFETSQV
410 420 430
LRPSRQALES PQLQADYDSC WATLPSTFNP NRR
Length:433
Mass (Da):48,300
Last modified:June 13, 2006 - v1
Checksum:iD8D621C6F6C28220
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA Translation: CAK17286.1
RefSeqiWP_011535651.1, NC_008027.1

Genome annotation databases

EnsemblBacteriaiCAK17286; CAK17286; PSEEN4612
GeneIDi32807590
KEGGipen:PSEEN4612

Similar proteinsi

Entry informationi

Entry nameiHGD_PSEE4
AccessioniPrimary (citable) accession number: Q1I500
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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