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Q1I500

- HGD_PSEE4

UniProt

Q1I500 - HGD_PSEE4

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei288 – 2881Proton acceptorUniRule annotation
Metal bindingi331 – 3311IronUniRule annotation
Metal bindingi337 – 3371IronUniRule annotation
Binding sitei346 – 3461homogentisateUniRule annotation
Metal bindingi367 – 3671IronUniRule annotation
Binding sitei367 – 3671homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciPENT384676:GJB8-4382-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:PSEEN4612
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000658: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Homogentisate 1,2-dioxygenasePRO_1000019534Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi384676.PSEEN4612.

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiSITTECG.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1I500-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRDTSPQLQ YLSGFGNEFA SEALPGALPV GQNSPQKAPY GLYAELLSGT
60 70 80 90 100
AFTMTRSELR RTWLYRIRPS ALHPRFERLE RQPLTGALGA ITPNRLRWSP
110 120 130 140 150
QPMPAEPTDF IEGWLPMVAN SASEKPAGVS IYIYRANRSM ERVFFNADGE
160 170 180 190 200
LLLVPEQGRL RIATELGVLE VEPLEIAVIP RGMKFRVELL DDQARGYIAE
210 220 230 240 250
NHGAPLRIPD LGPIGSNGLA NPRDFLTPVA HYEETSGPVQ LVQKFLGEHW
260 270 280 290 300
ACELQHSPLD VVAWHGSNVP YKYDLRRFNT IGTVSFDHPD PSIFTVLTSP
310 320 330 340 350
TSVHGMANMD FVIFPPRWMV AENTFRPPWF HRNLMNEFMG LIQGAYDAKA
360 370 380 390 400
EGFLPGGASL HGVMSAHGPD AETCDKAISV DLAPHKIDNT MAFMFETSQV
410 420 430
LRPSRQALES PQLQADYDSC WATLPSTFNP NRR
Length:433
Mass (Da):48,300
Last modified:June 13, 2006 - v1
Checksum:iD8D621C6F6C28220
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA. Translation: CAK17286.1.
RefSeqiYP_610069.1. NC_008027.1.

Genome annotation databases

EnsemblBacteriaiCAK17286; CAK17286; PSEEN4612.
GeneIDi4089231.
KEGGipen:PSEEN4612.
PATRICi19867254. VBIPseEnt83862_4432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA. Translation: CAK17286.1 .
RefSeqi YP_610069.1. NC_008027.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 384676.PSEEN4612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK17286 ; CAK17286 ; PSEEN4612 .
GeneIDi 4089231.
KEGGi pen:PSEEN4612.
PATRICi 19867254. VBIPseEnt83862_4432.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi SITTECG.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci PENT384676:GJB8-4382-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
    Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
    Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L48.

Entry informationi

Entry nameiHGD_PSEE4
AccessioniPrimary (citable) accession number: Q1I500
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3