Q1I4N9 (Q1I4N9_PSEE4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 2 HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase 2 HAMAP MF_01123
Acyl-activating enzyme 2 HAMAP MF_01123

Gene names

Name:	acs-2 EMBL CAK17397.1
Synonyms:	acsA2 HAMAP MF_01123
Ordered Locus Names:	PSEEN4738

Organism

Pseudomonas entomophila (strain L48) [Complete proteome] [HAMAP]

Taxonomic identifier

384676 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL CAK17397.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	513	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	605	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q1I4N9 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: EF7B2AA9294F95D8	FASTA	644	71,050
	10 20 30 40 50 60 MFDIRDSPQA LAVSQAAQLS DDDYRRLYRQ SIDDPDTFWA KQAKRLDWIK PWSSVQQCDL 70 80 90 100 110 120 KTGKARWFDG AQLNVSHNCI DRHLAQRGEQ TALLWEGDDP GDSKAVSYRE LHRQVCRLAN 130 140 150 160 170 180 ALKARGVKKG DRVCIYMPMI PEAAYAMLAC TRIGAIHSVV FGGFSPDALR DRILDADCRT 190 200 210 220 230 240 VITADEGIRG GKRIPLKENV DKALASCPAV SSVLVVKRTG ADVTWSQGRD LWYHEATEKA 250 260 270 280 290 300 GDDCPAEPME AEDPLFILYT SGSTGKPKGV LHTTGGYLLQ ATLTFKVVFD YRDGEVFWCT 310 320 330 340 350 360 ADVGWVTGHS YIVYGPLANG ATSLMFEGVP NYPDTSRFWQ VVDKHKVNIF YTAPTALRAL 370 380 390 400 410 420 MREGSAPLQT TSRQSLRLLG SVGEPINPEA WEWYFEAVGQ KRCPIVDTWW QTETGGIMLT 430 440 450 460 470 480 PLPGTPRLKP GCATQPMFGV QPVLLDEKGK LIEGPGAGLL AIKASWPGQI RSVYGDHQRM 490 500 510 520 530 540 VDTYFKPLPG YYFTGDGARR DADGDYWITG RIDDVINVSG HRIGTAEVES ALVLHDSVAE 550 560 570 580 590 600 AAVVGYPHDL KGQGIYAFVT PMSGVTPDDA LKQELLALVS KEIGSFAKPE LIQWAPALPK 610 620 630 640 TRSGKIMRRI LRKIACNELD NLGDTSTLAD PSVVQGLIDK RLNQ

References

[1]

"Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila." Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F. Nat. Biotechnol. 24:673-679(2006) [PubMed: 16699499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

[2]

Genoscope Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573326 Genomic DNA. Translation: CAK17397.1.
RefSeq	YP_610180.1. NC_008027.1.
3D structure databases
ProteinModelPortal	Q1I4N9.
SMR	Q1I4N9. Positions 19-641.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1I4N9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4089603.
GenomeReviews	Gene locus PSEEN4738 in contig CT573326_GR.
KEGG	pen:PSEEN4738.
NMPDR	fig|384676.6.peg.4080.
PATRIC	19867490. VBIPseEnt83862_4542.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	HQRMVDT.
PhylomeDB	Q1I4N9.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	PENT384676:PSEEN4738-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1I4N9_PSEE4

Accession

Primary (citable) accession number: Q1I4N9

Entry history

Integrated into UniProtKB/TrEMBL:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)