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Q1I4G7

- SYL_PSEE4

UniProt

Q1I4G7 - SYL_PSEE4

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Protein
Leucine--tRNA ligase
Gene
leuS, PSEEN4813
Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei630 – 6301ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPENT384676:GJB8-4575-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PSEEN4813
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000658: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 868868Leucine--tRNA ligaseUniRule annotation
PRO_1000009399Add
BLAST

Proteomic databases

PRIDEiQ1I4G7.

Interactioni

Protein-protein interaction databases

STRINGi384676.PSEEN4813.

Structurei

3D structure databases

ProteinModelPortaliQ1I4G7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi627 – 6315"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1I4G7-1 [UniParc]FASTAAdd to Basket

« Hide

MHEQYTPRDV EAAAQNAWDE QQSFAVTEQP GKETYYCLSM FPYPSGKLHM    50
GHVRNYTIGD VIARYQRMLG KNVLQPMGWD AFGMPAENAA MKNNVAPAKW 100
TYENIDYMKT QLKSLGLAID WSREVTTCKP DYYRWEQWLF TRLFEKGVIY 150
RKNGTVNWDP ADQTVLANEQ VIDGRGWRSG ALIEKREIPM YYFRITDYAD 200
ELLESLDELP GWPEQVKTMQ RNWIGKSRGM EVQFPYDQAS IGHEGTLKVF 250
TTRPDTLMGA TYVAVAAEHP LATQAAQGNA ALQAFIDECK SGSVAEADMA 300
TQEKKGMATS LFVEHPLTGE KLPVWVANYV LMHYGDGAVM AVPAHDERDF 350
EFAHKYNLPV KAVVRTSAGD DVGSEWLAAY GEHGQLINSG EFDGLDFQGA 400
FDAIEAALIR KDLGKSRTQF RLRDWGISRQ RYWGCPIPII HCPSCGDVPV 450
PEDQLPVTLP ENVVPDGAGS PLARMPEFYE CTCPKCGTAA KRETDTMDTF 500
VESSWYFARY ASPNYDKGLV DPKAANHWLP VDQYIGGIEH AILHLLYARF 550
FHKLMRDEGL VTSNEPFKNL LTQGMVVAET YYRVASNGGK DWFNPADVEI 600
ERDAKAKIIG ARLKTDGLPV EIGGTEKMSK SKNNGVDPQS MIEQYGADTC 650
RLFMMFASPP DMSLEWSDSG VEGASRFLRR VWRLAQAHVA QGLPGQLDIA 700
ALSDEQKVIR RAIHAAIKQA STDVGQFHKF NTAIAQVMTV MNVLEKAPQV 750
TAQDRALLQE GLEAVTLLLA PITPHISHEL WKQLGHEQAV IDATWPSVDE 800
SALVQDTVTL VVQVNGKLRG QVEMPAAASR EEIEAAARNN ENVLRFTDGL 850
TIRKVIVVPG KLVNIVAN 868
Length:868
Mass (Da):96,897
Last modified:June 13, 2006 - v1
Checksum:iF7E1D3C9EBEE57F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573326 Genomic DNA. Translation: CAK17469.1.
RefSeqiYP_610252.1. NC_008027.1.

Genome annotation databases

EnsemblBacteriaiCAK17469; CAK17469; PSEEN4813.
GeneIDi4088986.
KEGGipen:PSEEN4813.
PATRICi19867634. VBIPseEnt83862_4614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573326 Genomic DNA. Translation: CAK17469.1 .
RefSeqi YP_610252.1. NC_008027.1.

3D structure databases

ProteinModelPortali Q1I4G7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 384676.PSEEN4813.

Proteomic databases

PRIDEi Q1I4G7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK17469 ; CAK17469 ; PSEEN4813 .
GeneIDi 4088986.
KEGGi pen:PSEEN4813.
PATRICi 19867634. VBIPseEnt83862_4614.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PENT384676:GJB8-4575-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
    Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
    Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L48.

Entry informationi

Entry nameiSYL_PSEE4
AccessioniPrimary (citable) accession number: Q1I4G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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