Q1I3L0 (MSRA_PSEE4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	PSEEN5148

Organism

Pseudomonas entomophila (strain L48) [Complete proteome] [HAMAP]

Taxonomic identifier

384676 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_1000068351
Sites
	Active site	60	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1I3L0 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 8D021FCE161AA158	FASTA	222	24,491
	10 20 30 40 50 60 MVLRSEILVN KNVLPTAEQA LPGRETPMAL PEFHYVFEGT PLLGPFFEGD IDFAIFALGC 70 80 90 100 110 120 FWGAERRFWQ REGVVSTVVG YAGGFTPNPT YEEVCSGLTG HTEVVLVVFD KNKVSYHDLL 130 140 150 160 170 180 TMFWELHNPT QGMRQGNDVG TQYRSAIYCT SPQQLEEAKT SRDAFQAELS KAGFGEITTE 190 200 210 220 IAQAPTVYFA EAYHQQYLAK NPDGYCGIGG TGVCLPPSLQ GN

References

[1]

"Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila." Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F. Nat. Biotechnol. 24:673-679(2006) [PubMed: 16699499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L48.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573326 Genomic DNA. Translation: CAK17776.1.
RefSeq	YP_610559.1. NC_008027.1.
3D structure databases
ProteinModelPortal	Q1I3L0.
SMR	Q1I3L0. Positions 16-216.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1I3L0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4085797.
GenomeReviews	Gene locus PSEEN5148 in contig CT573326_GR.
KEGG	pen:PSEEN5148.
NMPDR	fig|384676.6.peg.4453.
PATRIC	19868296. VBIPseEnt83862_4943.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	SAIYCTS.
PhylomeDB	Q1I3L0.
ProtClustDB	PRK00058.
Enzyme and pathway databases
BioCyc	PENT384676:PSEEN5148-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_PSEE4

Accession

Primary (citable) accession number: Q1I3L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program