Q1I2W1 (XPT_PSEE4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xanthine phosphoribosyltransferase
Short name=XPRTase
EC=2.4.2.22

Gene names

Name:	xpt
Ordered Locus Names:	PSEEN5411

Organism

Pseudomonas entomophila (strain L48) [Complete proteome] [HAMAP]

Taxonomic identifier

384676 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas entomophila

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis By similarity. HAMAP-Rule MF_01184
Catalytic activity	XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. HAMAP-Rule MF_01184
Pathway	Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. HAMAP-Rule MF_01184
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_01184.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	XMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway purine ribonucleoside salvage Inferred from electronic annotation. Source: HAMAP xanthine metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	xanthine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Xanthine phosphoribosyltransferase HAMAP-Rule MF_01184		PRO_0000339730
Regions
	Region	128 – 132	5	5-phospho-alpha-D-ribose 1-diphosphate binding By similarity
Sites
	Binding site	20	1	Xanthine; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	27	1	Xanthine By similarity
	Binding site	156	1	Xanthine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1I2W1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: A6BE27489576392A	FASTA	190	20,408
	10 20 30 40 50 60 MEALQQKIRE EGIVLSDQVL KVDAFLNHQI DPALMQLIGD EFARLFADSG VTKIVTIEAS 70 80 90 100 110 120 GIAPAVMTGL KLGVPVIFAR KHQSLTLTEN LLTASVYSFT KQTENTVAIS PRHLNSSDRV 130 140 150 160 170 180 LVIDDFLANG KASQALISII KQAGATVAGL GIVIEKSFQG GRAELDSQGY RVESLARVKS 190 LEGGVVTFIE

References

[1]

"Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila." Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F. Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L48.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573326 Genomic DNA. Translation: CAK18025.1.
RefSeq	YP_610808.1. NC_008027.1.
3D structure databases
ProteinModelPortal	Q1I2W1.
SMR	Q1I2W1. Positions 1-190.
ModBase	Search...
Protein-protein interaction databases
STRING	384676.PSEEN5411.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAK18025; CAK18025; PSEEN5411.
GeneID	4087266.
KEGG	pen:PSEEN5411.
PATRIC	19868800. VBIPseEnt83862_5193.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0503.
HOGENOM	HOG000036777.
KO	K03816.
OMA	ATVYSFT.
ProtClustDB	PRK09219.
Enzyme and pathway databases
BioCyc	PENT384676:GJB8-5136-MONOMER.
UniPathway	UPA00602; UER00658.
Family and domain databases
HAMAP	MF_01184. XPRTase.
InterPro	IPR000836. PRibTrfase_dom. IPR010079. Xanthine_PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01744. XPRTase. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XPT_PSEE4

Accession

Primary (citable) accession number: Q1I2W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 13, 2006
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program