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Protein

Probable chorismate pyruvate-lyase 2

Gene

ubiC2

Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.UniRule annotation

Catalytic activityi

Chorismate = 4-hydroxybenzoate + pyruvate.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80SubstrateUniRule annotation1
Binding sitei118Substrate; via amide nitrogenUniRule annotation1
Binding sitei170SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chorismate pyruvate-lyase 2UniRule annotation (EC:4.1.3.40UniRule annotation)
Short name:
CL 2UniRule annotation
Short name:
CPL 2UniRule annotation
Gene namesi
Name:ubiC2UniRule annotation
Ordered Locus Names:PSEEN5461
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000658 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920731 – 185Probable chorismate pyruvate-lyase 2Add BLAST185

Interactioni

Protein-protein interaction databases

STRINGi384676.PSEEN5461.

Structurei

3D structure databases

ProteinModelPortaliQ1I2R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VEI. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000137785.
KOiK03181.
OMAiEVCHYPE.
OrthoDBiPOG091H047C.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC. 1 hit.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1I2R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYETPQAAA VAWLPYSQLA TTLDQPTLDW LFDEGSLTRR LTRLSHDHFS
60 70 80 90 100
VTPLFEGWQP LRDDECAALG LAPGEEGWVR EVYLRGHDQP WVFARSVAGR
110 120 130 140 150
SVLERGGLDL ETLGTRSLGE LLFCDQAFIR HPLEACRYPQ TWLPTKVAHE
160 170 180
GLWGRRSRFE RSGLDLLVAE VFLPALWQAA KEETR
Length:185
Mass (Da):21,060
Last modified:June 13, 2006 - v1
Checksum:i538A795DA07D352A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA. Translation: CAK18072.1.
RefSeqiWP_011536424.1. NC_008027.1.

Genome annotation databases

EnsemblBacteriaiCAK18072; CAK18072; PSEEN5461.
KEGGipen:PSEEN5461.
PATRICi19868906. VBIPseEnt83862_5246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573326 Genomic DNA. Translation: CAK18072.1.
RefSeqiWP_011536424.1. NC_008027.1.

3D structure databases

ProteinModelPortaliQ1I2R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi384676.PSEEN5461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK18072; CAK18072; PSEEN5461.
KEGGipen:PSEEN5461.
PATRICi19868906. VBIPseEnt83862_5246.

Phylogenomic databases

eggNOGiENOG4105VEI. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000137785.
KOiK03181.
OMAiEVCHYPE.
OrthoDBiPOG091H047C.

Enzyme and pathway databases

UniPathwayiUPA00232.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC. 1 hit.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBIC2_PSEE4
AccessioniPrimary (citable) accession number: Q1I2R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.