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Q1I2L2

- GCH4_PSEE4

UniProt

Q1I2L2 - GCH4_PSEE4

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, PSEEN5515
Organism
Pseudomonas entomophila (strain L48)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPENT384676:GJB8-5235-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:PSEEN5515
OrganismiPseudomonas entomophila (strain L48)
Taxonomic identifieri384676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000658: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293GTP cyclohydrolase FolE2UniRule annotation
PRO_0000289508Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi384676.PSEEN5515.

Structurei

3D structure databases

ProteinModelPortaliQ1I2L2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1I2L2-1 [UniParc]FASTAAdd to Basket

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MTSLTLPDIA AQSAQQPLPL DWVGMCGIAM PVQFEGRQLS ALADAGVSLD    50
DGASRGIHMS RLYLALEALE RDTLTPRLIH QVLEQFLFSH EGLSASAHLR 100
LQFDHLLKRP ALVSPLAGWK HYPVAIDARL KAEMFHVELS VEIPYSSTCP 150
CSAALARQLI QERFDQDFTG QAVDRQGVRA WLGSSSGIVA TPHSQRSMAK 200
LQVRLVGDEL PVTVLIDKAE AALGTAVQTA VKRADEQAFA LANGQNLMFC 250
EDAARRLNLA LRQLDWVAGF TVRVEHAESL HAHDAVAVSR FQR 293
Length:293
Mass (Da):32,104
Last modified:June 13, 2006 - v1
Checksum:i4F15FC121C52FA4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573326 Genomic DNA. Translation: CAK18124.1.
RefSeqiWP_011536476.1. NC_008027.1.
YP_610907.1. NC_008027.1.

Genome annotation databases

EnsemblBacteriaiCAK18124; CAK18124; PSEEN5515.
GeneIDi4090382.
KEGGipen:PSEEN5515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573326 Genomic DNA. Translation: CAK18124.1 .
RefSeqi WP_011536476.1. NC_008027.1.
YP_610907.1. NC_008027.1.

3D structure databases

ProteinModelPortali Q1I2L2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 384676.PSEEN5515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK18124 ; CAK18124 ; PSEEN5515 .
GeneIDi 4090382.
KEGGi pen:PSEEN5515.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PENT384676:GJB8-5235-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila."
    Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F.
    Nat. Biotechnol. 24:673-679(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L48.

Entry informationi

Entry nameiGCH4_PSEE4
AccessioniPrimary (citable) accession number: Q1I2L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 13, 2006
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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