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Protein

Dystrobrevin

Gene

DTNB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DystrobrevinUniRule annotation
Gene namesi
Name:DTNBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ1I0L3.
PeptideAtlasiQ1I0L3.
PRIDEiQ1I0L3.

PTM databases

iPTMnetiQ1I0L3.

Expressioni

Gene expression databases

BgeeiQ1I0L3.
GenevisibleiQ1I0L3. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384084.

Structurei

3D structure databases

ProteinModelPortaliQ1I0L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini237 – 28448ZZ-typeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili429 – 46032Sequence analysisAdd
BLAST
Coiled coili475 – 51945Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the dystrophin family. Dystrobrevin subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG4301. Eukaryota.
ENOG410XP3C. LUCA.
HOVERGENiHBG005539.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038204. Distrobrevin. 1 hit.
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1I0L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL
60 70 80 90 100
HLVDIWNMIE AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH
110 120 130 140 150
QISVEQSISL LLNFMIAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY
160 170 180 190 200
VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA VFEGPSFGYT EHSVRTCFPQ
210 220 230 240 250
QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCRCES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS
310 320 330 340 350
HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM
360 370 380 390 400
SSGVPTPTKR LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE
410 420 430 440 450
EHRLIARYAA RLAAEAGNVT RPPTDLSFNF DANKQQRQLI AELENKNREI
460 470 480 490 500
LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ
510 520 530 540 550
ESRRELMVQL EELMKLLKAQ ATGSPHTSPT HGGGRPMPMP VRSTSAGSTP
560 570 580 590 600
THCPQDSLSG VGGDVQEAFA QGTRRNLRND LLVAADSITN TMSSLVKELH

SG
Length:602
Mass (Da):68,452
Last modified:June 13, 2006 - v1
Checksum:i863DD6D4C17EF7BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ160290 mRNA. Translation: ABA08463.1.
RefSeqiNP_001243233.1. NM_001256304.1.
XP_005264239.1. XM_005264182.1.
UniGeneiHs.307720.

Genome annotation databases

GeneIDi1838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ160290 mRNA. Translation: ABA08463.1.
RefSeqiNP_001243233.1. NM_001256304.1.
XP_005264239.1. XM_005264182.1.
UniGeneiHs.307720.

3D structure databases

ProteinModelPortaliQ1I0L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384084.

PTM databases

iPTMnetiQ1I0L3.

Proteomic databases

PaxDbiQ1I0L3.
PeptideAtlasiQ1I0L3.
PRIDEiQ1I0L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1838.

Organism-specific databases

CTDi1838.

Phylogenomic databases

eggNOGiKOG4301. Eukaryota.
ENOG410XP3C. LUCA.
HOVERGENiHBG005539.

Miscellaneous databases

ChiTaRSiDTNB. human.
GenomeRNAii1838.

Gene expression databases

BgeeiQ1I0L3.
GenevisibleiQ1I0L3. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038204. Distrobrevin. 1 hit.
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein."
    Nazarian R., Starcevic M., Spencer M.J., Dell'Angelica E.C.
    Biochem. J. 395:587-598(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ1I0L3_HUMAN
AccessioniPrimary (citable) accession number: Q1I0L3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: July 6, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.