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Q1HQW5 (Q1HQW5_AEDAE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
ORF Names:AAEL000746 EMBL EAT48221.1
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome] EMBL ABF18362.1
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding309 – 3146NADP By similarity
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2591NADP By similarity
Binding site3271NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q1HQW5 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 03288FBD883AE29C

FASTA40945,838
        10         20         30         40         50         60 
MAAKIKAGPV VDILGDEMTR IIWDSIKEKL ILPFLDIELH TYDLGMEHRD KTDDQVTIDC 

        70         80         90        100        110        120 
AEAVKKYNVG IKCATITPDE ARVKEFNLKK MWRSPNGTIR NILGGTVFRE AIICKNIPRL 

       130        140        150        160        170        180 
VPGWEKPIVI GRHAHGDQYK ATDFVVPGAG DLEIKFTPKA GGEPISYVVH QYKGPGVAMA 

       190        200        210        220        230        240 
MYNLDDSIVD FAHSSFKVAL DRKFPLYLST KNTILKKYDG RFKDIFQEIY EKEYKTQFEA 

       250        260        270        280        290        300 
AGIWYEHRLI DDMVAYCMKA EGGFVWACKN YDGDVQSDTV AQGFGSLGLM TSVLVCPDGK 

       310        320        330        340        350        360 
TVEAEAAHGT VTRHYRQYQQ GKETSTNPIA SIFAWTRGLL HRAKLDNNAE LKKFAETLEK 

       370        380        390        400 
VCIDTIESGS MTKDLAICIK GMANVTRADY LETFEFMTKL GDNLKAALA 

« Hide

References

« Hide 'large scale' references
[1]Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P., Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H., Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G. expand/collapse author list , Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Liverpool EMBL EAT48221.1.
[2]Ribeiro J.M.C., Chandra P.K., Calvo E., Pham V.M., Wikel S.K.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"An annotated catalogue of salivary gland transcripts in the adult female mosquito, Aedes aegypti."
Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K., Wikel S.K.
BMC Genomics 8:6-6(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]"Genome sequence of Aedes aegypti, a major arbovirus vector."
Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. expand/collapse author list , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W.
Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Liverpool EMBL EAT48221.1 and LVPib12.
[5]VectorBase
Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Liverpool EMBL EAT48221.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ440329 mRNA. Translation: ABF18362.1.
CH477200 Genomic DNA. Translation: EAT48221.1.
RefSeqXP_001650675.1. XM_001650625.1.
UniGeneAae.11291.

3D structure databases

ProteinModelPortalQ1HQW5.
SMRQ1HQW5. Positions 4-409.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7159.AAEL000746-PA.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL000746-RA; AAEL000746-PA; AAEL000746.
GeneID5566298.
KEGGaag:AaeL_AAEL000746.
VectorBaseAAEL000746. Aedes aegypti.

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
InParanoidQ1HQW5.
KOK00031.
OMAKELSFFA.
OrthoDBEOG7QNVKS.
PhylomeDBQ1HQW5.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1HQW5_AEDAE
AccessionPrimary (citable) accession number: Q1HQW5
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)