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Q1HQW5

- Q1HQW5_AEDAE

UniProt

Q1HQW5 - Q1HQW5_AEDAE

Protein

Isocitrate dehydrogenase [NADP]

Gene

AAEL000746

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei211 – 2111Critical for catalysisUniRule annotation
    Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
    Binding sitei259 – 2591NADPUniRule annotation
    Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
    Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi309 – 3146NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:AAEL000746Imported
    OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
    Taxonomic identifieri7159 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
    ProteomesiUP000008820: Unassembled WGS sequence

    Interactioni

    Protein-protein interaction databases

    STRINGi7159.AAEL000746-PA.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    InParanoidiQ1HQW5.
    KOiK00031.
    OMAiCVNTVET.
    OrthoDBiEOG7QNVKS.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1HQW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAKIKAGPV VDILGDEMTR IIWDSIKEKL ILPFLDIELH TYDLGMEHRD    50
    KTDDQVTIDC AEAVKKYNVG IKCATITPDE ARVKEFNLKK MWRSPNGTIR 100
    NILGGTVFRE AIICKNIPRL VPGWEKPIVI GRHAHGDQYK ATDFVVPGAG 150
    DLEIKFTPKA GGEPISYVVH QYKGPGVAMA MYNLDDSIVD FAHSSFKVAL 200
    DRKFPLYLST KNTILKKYDG RFKDIFQEIY EKEYKTQFEA AGIWYEHRLI 250
    DDMVAYCMKA EGGFVWACKN YDGDVQSDTV AQGFGSLGLM TSVLVCPDGK 300
    TVEAEAAHGT VTRHYRQYQQ GKETSTNPIA SIFAWTRGLL HRAKLDNNAE 350
    LKKFAETLEK VCIDTIESGS MTKDLAICIK GMANVTRADY LETFEFMTKL 400
    GDNLKAALA 409
    Length:409
    Mass (Da):45,838
    Last modified:June 13, 2006 - v1
    Checksum:i03288FBD883AE29C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ440329 mRNA. Translation: ABF18362.1.
    CH477200 Genomic DNA. Translation: EAT48221.1.
    RefSeqiXP_001650675.1. XM_001650625.1.
    UniGeneiAae.11291.

    Genome annotation databases

    EnsemblMetazoaiAAEL000746-RA; AAEL000746-PA; AAEL000746.
    GeneIDi5566298.
    KEGGiaag:AaeL_AAEL000746.
    VectorBaseiAAEL000746. Aedes aegypti.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ440329 mRNA. Translation: ABF18362.1 .
    CH477200 Genomic DNA. Translation: EAT48221.1 .
    RefSeqi XP_001650675.1. XM_001650625.1.
    UniGenei Aae.11291.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7159.AAEL000746-PA.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AAEL000746-RA ; AAEL000746-PA ; AAEL000746 .
    GeneIDi 5566298.
    KEGGi aag:AaeL_AAEL000746.
    VectorBasei AAEL000746. Aedes aegypti.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    InParanoidi Q1HQW5.
    KOi K00031.
    OMAi CVNTVET.
    OrthoDBi EOG7QNVKS.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LiverpoolImported.
    2. Ribeiro J.M.C., Chandra P.K., Calvo E., Pham V.M., Wikel S.K.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "An annotated catalogue of salivary gland transcripts in the adult female mosquito, Aedes aegypti."
      Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K., Wikel S.K.
      BMC Genomics 8:6-6(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "Genome sequence of Aedes aegypti, a major arbovirus vector."
      Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
      , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W.
      Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LiverpoolImported and LVPib12Imported.
    5. VectorBase
      Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LiverpoolImported.

    Entry informationi

    Entry nameiQ1HQW5_AEDAE
    AccessioniPrimary (citable) accession number: Q1HQW5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3