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Q1HQW5

- Q1HQW5_AEDAE

UniProt

Q1HQW5 - Q1HQW5_AEDAE

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Protein

Isocitrate dehydrogenase [NADP]

Gene

AAEL000746

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei211 – 2111Critical for catalysisUniRule annotation
Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
Binding sitei259 – 2591NADPUniRule annotation
Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi309 – 3146NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:AAEL000746Imported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL000746-PA.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiCVNTVET.
OrthoDBiEOG7QNVKS.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1HQW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAKIKAGPV VDILGDEMTR IIWDSIKEKL ILPFLDIELH TYDLGMEHRD
60 70 80 90 100
KTDDQVTIDC AEAVKKYNVG IKCATITPDE ARVKEFNLKK MWRSPNGTIR
110 120 130 140 150
NILGGTVFRE AIICKNIPRL VPGWEKPIVI GRHAHGDQYK ATDFVVPGAG
160 170 180 190 200
DLEIKFTPKA GGEPISYVVH QYKGPGVAMA MYNLDDSIVD FAHSSFKVAL
210 220 230 240 250
DRKFPLYLST KNTILKKYDG RFKDIFQEIY EKEYKTQFEA AGIWYEHRLI
260 270 280 290 300
DDMVAYCMKA EGGFVWACKN YDGDVQSDTV AQGFGSLGLM TSVLVCPDGK
310 320 330 340 350
TVEAEAAHGT VTRHYRQYQQ GKETSTNPIA SIFAWTRGLL HRAKLDNNAE
360 370 380 390 400
LKKFAETLEK VCIDTIESGS MTKDLAICIK GMANVTRADY LETFEFMTKL

GDNLKAALA
Length:409
Mass (Da):45,838
Last modified:June 13, 2006 - v1
Checksum:i03288FBD883AE29C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ440329 mRNA. Translation: ABF18362.1.
CH477200 Genomic DNA. Translation: EAT48221.1.
RefSeqiXP_001650675.1. XM_001650625.1.
UniGeneiAae.11291.

Genome annotation databases

EnsemblMetazoaiAAEL000746-RA; AAEL000746-PA; AAEL000746.
GeneIDi5566298.
KEGGiaag:AaeL_AAEL000746.
VectorBaseiAAEL000746. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ440329 mRNA. Translation: ABF18362.1 .
CH477200 Genomic DNA. Translation: EAT48221.1 .
RefSeqi XP_001650675.1. XM_001650625.1.
UniGenei Aae.11291.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7159.AAEL000746-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AAEL000746-RA ; AAEL000746-PA ; AAEL000746 .
GeneIDi 5566298.
KEGGi aag:AaeL_AAEL000746.
VectorBasei AAEL000746. Aedes aegypti.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi CVNTVET.
OrthoDBi EOG7QNVKS.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LiverpoolImported.
  2. Ribeiro J.M.C., Chandra P.K., Calvo E., Pham V.M., Wikel S.K.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "An annotated catalogue of salivary gland transcripts in the adult female mosquito, Aedes aegypti."
    Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K., Wikel S.K.
    BMC Genomics 8:6-6(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LiverpoolImported and LVPib12Imported.
  5. VectorBase
    Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LiverpoolImported.

Entry informationi

Entry nameiQ1HQW5_AEDAE
AccessioniPrimary (citable) accession number: Q1HQW5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3