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Q1HQR0 (Q1HQR0_AEDAE) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase RuleBase RU000548
EC=3.3.1.1 RuleBase RU000548
Gene names
ORF Names:AAEL008341, AaeL_AAEL008341 EMBL EAT39891.1
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti) EMBL ABF18417.1
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548

Cofactor

NAD By similarity. RuleBase RU000548

Pathway

Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548

Sequence similarities

Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
   Biological processOne-carbon metabolism RuleBase RU000548
   LigandNAD RuleBase RU000548
   Molecular functionHydrolase RuleBase RU000548 EMBL ABF18417.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site561Substrate By similarity PIRSR PIRSR001109-1
Binding site1311Substrate By similarity PIRSR PIRSR001109-1
Binding site1561Substrate By similarity PIRSR PIRSR001109-1
Binding site1861Substrate By similarity PIRSR PIRSR001109-1
Binding site1901Substrate By similarity PIRSR PIRSR001109-1

Sequences

Sequence LengthMass (Da)Tools
Q1HQR0 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 767A0C990D46EFC3

FASTA43247,634
        10         20         30         40         50         60 
MSKPDYKVAD ISLADFGRKE IMLAENEMPG LMACRKKYGP QKVLKGARIA GCLHMTIQTA 

        70         80         90        100        110        120 
VLIETLVELG AEVQWSSCNI FSTQDHAAAA IAKTGVPVYA WKGETDEEYM WCIRQTLVFK 

       130        140        150        160        170        180 
DGQPLNMILD DGGDLTNLVH TEYPQYLEGI KGISEETTTG VHNLYKMLKE GKLGVPAINV 

       190        200        210        220        230        240 
NDSVTKSKFD NLYGCRESLL DGIKRATDVM IAGKVCVVAG YGDVGKGCAQ ALKGFGGRVL 

       250        260        270        280        290        300 
VTEIDPINAL QAAMEGYEVT TMEEASKEAQ IFVTTTGCTD IIMGEHFMNM KDDSIVCNIG 

       310        320        330        340        350        360 
HFDCEVNVAW LEQNAKEKVN IKPQVDRYLL PSGNHVILLA EGRLVNLGCA TGHSSFVMSN 

       370        380        390        400        410        420 
SFTNQVLAQI ELWTKPSEYK VGVYVLPKKL DEEVAALHLD KLGVKLTRLS ARQAEYLNMP 

       430 
VDGPYKPEHY RY

« Hide

References

« Hide 'large scale' references
[1]"An annotated catalogue of salivary gland transcripts in the adult female mosquito, Aedes aegypti."
Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K., Wikel S.K.
BMC Genomics 8:6-6(2007) [PubMed: 17204158] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Genome sequence of Aedes aegypti, a major arbovirus vector."
Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. expand/collapse author list , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
Science 316:1718-1723(2007) [PubMed: 17510324] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LVPib12.
[3]Ribeiro J.M.C., Chandra P.K., Calvo E., Pham V.M., Wikel S.K.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ440384 mRNA. Translation: ABF18417.1.
CH477503 Genomic DNA. Translation: EAT39891.1.
RefSeqXP_001659155.1. XM_001659105.1.
UniGeneAae.26229.
Aae.8541.

3D structure databases

ProteinModelPortalQ1HQR0.
SMRQ1HQR0. Positions 6-432.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1HQR0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL008341-RA; AAEL008341-PA; AAEL008341.
GeneID5570455.
KEGGaag:AaeL_AAEL008341.
VectorBaseAAEL008341. Aedes aegypti.

Phylogenomic databases

eggNOGinNOG07176.
GeneTreeEMGT00050000015433.
InParanoidQ1HQR0.
OMAMKEDAIV.
OrthoDBEOG45DV4T.
PhylomeDBQ1HQR0.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1HQR0_AEDAE
AccessionPrimary (citable) accession number: Q1HQR0
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info