Q1HQK0 (KAD2_AEDAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase 2, mitochondrial
Short name=AK 2
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase 2

Gene names

Name:	Adk2
ORF Names:	AAEL012731

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Adenylate kinase 2, mitochondrial		PRO_0000365700
Regions
	Nucleotide binding	26 – 34	9	ATP By similarity
	Nucleotide binding	49 – 78	30	AMP By similarity
Sites
	Binding site	50	1	AMP By similarity
Amino acid modifications
	Disulfide bond	46 ↔ 96		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1HQK0 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: C758A1CC5C9B8162	FASTA	241	26,273
	10 20 30 40 50 60 MAPNAAAVAP KPEQEQATGI NAILLGPPGS GKGTQAPLLK EKFCVCHLST GDMLRAEIAA 70 80 90 100 110 120 GSKLGAQLKK VMDEGKLVSD DLVVDMIDSN LDKPECKNGF LLDGFPRTVV QAEKLDDLLE 130 140 150 160 170 180 KRKTGLDAVV EFGIDDSLLV RRITGRLIHQ ASGRSYHEEF APPKVAMTDD VTGEPLMRRS 190 200 210 220 230 240 DDNAAALVKR LEAYHKQTKP LADYYALRGL HFRVDAAQSA SRVFENIDSI FTSQRKARMG L

References

[1]

"An annotated catalogue of salivary gland transcripts in the adult female mosquito, Aedes aegypti." Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K., Wikel S.K. BMC Genomics 8:6-6(2007) [PubMed: 17204158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Black-eyed Liverpool. Tissue: Salivary gland.

[2]

"Genome sequence of Aedes aegypti, a major arbovirus vector." Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W. Science 316:1718-1723(2007) [PubMed: 17510324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LVPib12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ440444 mRNA. Translation: ABF18477.1. CH477917 Genomic DNA. Translation: EAT35079.1.
RefSeq	XP_001662844.1. XM_001662794.1.
UniGene	Aae.11637.
3D structure databases
ProteinModelPortal	Q1HQK0.
SMR	Q1HQK0. Positions 19-232.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1HQK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AAEL012731-RA; AAEL012731-PA; AAEL012731.
GeneID	5576745.
KEGG	aag:AaeL_AAEL012731.
VectorBase	AAEL012731. Aedes aegypti.
Phylogenomic databases
eggNOG	inNOG04513.
GeneTree	EMGT00050000010442.
InParanoid	Q1HQK0.
OMA	SYHKIFN.
OrthoDB	EOG43BK4X.
PhylomeDB	Q1HQK0.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD2_AEDAE

Accession

Primary (citable) accession number: Q1HQK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)