Q1HQH0 (Q1HQH0_AEDAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

ORF Names:

AAEL002304, AaeL_AAEL002304 EMBL EAT46522.1

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti) EMBL ABF18507.1

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Molecular function	Lyase RuleBase RU000515
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	199	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	252	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	122	1	Zinc 1; catalytic By similarity PIRSR PIRSR001415-4
	Metal binding	124	1	Zinc 1; catalytic By similarity PIRSR PIRSR001415-4
	Metal binding	131	1	Zinc 2 By similarity PIRSR PIRSR001415-4
	Metal binding	132	1	Zinc 1; catalytic By similarity PIRSR PIRSR001415-4
	Metal binding	223	1	Zinc 2 By similarity PIRSR PIRSR001415-4
	Binding site	209	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	221	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	279	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	318	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q1HQH0 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: DF61FB83ABAAD958	FASTA	327	35,996
	10 20 30 40 50 60 MSSLTKLHSS IFHPTLRKLQ CQDVDIAAHN LMYPVFLVED DDAVQEIPSM PGVARYGLTT 70 80 90 100 110 120 LKKHLTPLVE KGLASILLFG VVDKLPKDPT GSGADSAENP VVKALPQLRQ WFPDLLIACD 130 140 150 160 170 180 VCLCPYTSHG HCGVLTADGV IDNEPSIQRI AEIAFAYAKA GAHIVAPSDM MDNRIWAIKK 190 200 210 220 230 240 ILRENKMENT VSVLSYSVKF ASGFYGPFRD AAKSAPAFGD RKCYQLPPGS KGIAKRAAKR 250 260 270 280 290 300 DVEEGADMLM VKPGMAYLDI VKQVKDDYPE LPLFIYQVSG EYSMLLNAGK IGAFDLRTVL 310 320 WEVLIGMRRA GADCIITYFT PTLLDWL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An annotated catalogue of salivary gland transcripts in the adult female mosquito, Aedes aegypti." Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K., Wikel S.K. BMC Genomics 8:6-6(2007) [PubMed: 17204158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Genome sequence of Aedes aegypti, a major arbovirus vector." Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W. Science 316:1718-1723(2007) [PubMed: 17510324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LVPib12.
[3]	Ribeiro J.M.C., Chandra P.K., Calvo E., Pham V.M., Wikel S.K. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ440474 mRNA. Translation: ABF18507.1. CH477238 Genomic DNA. Translation: EAT46522.1.
RefSeq	XP_001661237.1. XM_001661187.1.
UniGene	Aae.20281.
3D structure databases
ProteinModelPortal	Q1HQH0.
SMR	Q1HQH0. Positions 7-327.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1HQH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AAEL002304-RA; AAEL002304-PA; AAEL002304.
GeneID	5574180.
KEGG	aag:AaeL_AAEL002304.
VectorBase	AAEL002304. Aedes aegypti.
Phylogenomic databases
eggNOG	inNOG07757.
GeneTree	EMGT00050000016887.
InParanoid	Q1HQH0.
OMA	GAHCVAP.
OrthoDB	EOG4HX3GR.
PhylomeDB	Q1HQH0.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1HQH0_AEDAE

Accession

Primary (citable) accession number: Q1HQH0

Entry history

Integrated into UniProtKB/TrEMBL:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)