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Q1HPU2

- TRMB_BOMMO

UniProt

Q1HPU2 - TRMB_BOMMO

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei130 – 1301S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei133 – 1331 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine, tRNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    OrganismiBombyx mori (Silk moth)
    Taxonomic identifieri7091 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
    ProteomesiUP000005204: Unplaced

    Subcellular locationi

    Nucleus By similarity UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000370566Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ1HPU2.
    SMRiQ1HPU2. Positions 25-231.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni77 – 782S-adenosyl-L-methionine binding By similarity
    Regioni110 – 1112S-adenosyl-L-methionine binding By similarity
    Regioni208 – 2103S-adenosyl-L-methionine binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    KOiK03439.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1HPU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPQKKYYR QRAHSNPIAD HCFDYPSHPD DYDWTPLYPI ISEKPNQVEF    50
    LDVGCGYGGL LVALSPMFPS NLMLGSEIRV KVSDYVNDRI KALRVQYPDQ 100
    YQNVAVLRTN AMKYLPNFFH KGQLKKMFFL YPDPHFKKAK HKWRIINKWL 150
    LSEYAYVLCE QGIVYTITDV KDLNEWMVAH FEEHPLFESV PEEELKEDPI 200
    IEKLYESTEE GQKVTRNNGE KFLAVFRRIA DKTKTN 236
    Length:236
    Mass (Da):27,802
    Last modified:June 13, 2006 - v1
    Checksum:i33A20A8B8D556ECE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ443310 mRNA. Translation: ABF51399.1.
    RefSeqiNP_001040444.1. NM_001046979.1.
    UniGeneiBmo.7070.

    Genome annotation databases

    GeneIDi732983.
    KEGGibmor:732983.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ443310 mRNA. Translation: ABF51399.1 .
    RefSeqi NP_001040444.1. NM_001046979.1.
    UniGenei Bmo.7070.

    3D structure databases

    ProteinModelPortali Q1HPU2.
    SMRi Q1HPU2. Positions 25-231.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 732983.
    KEGGi bmor:732983.

    Phylogenomic databases

    KOi K03439.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Blast silkworm EST database for functional genes."
      Niu B.L., Meng Z.Q., Weng H.B., Shen W.F., He L.H., Zheng K.F., Ye S.T., Lin T.B., Chen J.E.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTRMB_BOMMO
    AccessioniPrimary (citable) accession number: Q1HPU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: June 13, 2006
    Last modified: June 11, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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