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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei130S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Active sitei133UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
Proteomesi
  • UP000005204 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003705661 – 236tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST236

Proteomic databases

PRIDEiQ1HPU2

Interactioni

Protein-protein interaction databases

STRINGi7091.BGIBMGA006783-TA

Structurei

3D structure databases

ProteinModelPortaliQ1HPU2
SMRiQ1HPU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni77 – 78S-adenosyl-L-methionine bindingUniRule annotation2
Regioni110 – 111S-adenosyl-L-methionine bindingUniRule annotation2
Regioni208 – 210S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3115 Eukaryota
COG0220 LUCA
KOiK03439

Family and domain databases

HAMAPiMF_03055 tRNA_methyltr_TrmB_euk, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025763 Trm8_euk
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
PTHR23417:SF16 PTHR23417:SF16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q1HPU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPQKKYYR QRAHSNPIAD HCFDYPSHPD DYDWTPLYPI ISEKPNQVEF
60 70 80 90 100
LDVGCGYGGL LVALSPMFPS NLMLGSEIRV KVSDYVNDRI KALRVQYPDQ
110 120 130 140 150
YQNVAVLRTN AMKYLPNFFH KGQLKKMFFL YPDPHFKKAK HKWRIINKWL
160 170 180 190 200
LSEYAYVLCE QGIVYTITDV KDLNEWMVAH FEEHPLFESV PEEELKEDPI
210 220 230
IEKLYESTEE GQKVTRNNGE KFLAVFRRIA DKTKTN
Length:236
Mass (Da):27,802
Last modified:June 13, 2006 - v1
Checksum:i33A20A8B8D556ECE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ443310 mRNA Translation: ABF51399.1
RefSeqiNP_001040444.1, NM_001046979.1
UniGeneiBmo.7070

Genome annotation databases

GeneIDi732983
KEGGibmor:732983

Similar proteinsi

Entry informationi

Entry nameiTRMB_BOMMO
AccessioniPrimary (citable) accession number: Q1HPU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 13, 2006
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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