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Q1HKZ5

- M3K13_MOUSE

UniProt

Q1HKZ5 - M3K13_MOUSE

Protein

Mitogen-activated protein kinase kinase kinase 13

Gene

Map3k13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by autophosphorylation and homodimerization.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei194 – 1941ATPPROSITE-ProRule annotation
    Active sitei278 – 2781Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi173 – 1819ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase kinase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. JNK cascade Source: Ensembl
    2. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    3. protein autophosphorylation Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 13 (EC:2.7.11.25)
    Gene namesi
    Name:Map3k13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2444243. Map3k13.

    Subcellular locationi

    Cytoplasm. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. IkappaB kinase complex Source: Ensembl
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 959959Mitogen-activated protein kinase kinase kinase 13PRO_0000277591Add
    BLAST

    Post-translational modificationi

    Autophosphorylated on serine and threonine residues.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ1HKZ5.
    PRIDEiQ1HKZ5.

    PTM databases

    PhosphoSiteiQ1HKZ5.

    Expressioni

    Gene expression databases

    BgeeiQ1HKZ5.
    CleanExiMM_MAP3K13.
    GenevestigatoriQ1HKZ5.

    Interactioni

    Subunit structurei

    Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000047388.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1HKZ5.
    SMRiQ1HKZ5. Positions 111-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini167 – 408242Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni432 – 45322Leucine-zipper 1Add
    BLAST
    Regioni485 – 50622Leucine-zipper 2Add
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117464.
    HOGENOMiHOG000113435.
    HOVERGENiHBG052383.
    InParanoidiQ1HKZ5.
    KOiK04422.
    OMAiHRRGNSR.
    OrthoDBiEOG7B8S3P.
    PhylomeDBiQ1HKZ5.
    TreeFamiTF105119.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR017419. MAP3K12_MAP3K13.
    IPR027258. MAPKKK13.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
    PIRSF500742. MAPKKK13. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1HKZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANPQEHLSC SSLPHLPLTE NKTSGGRNEL AAMGNHPSPK LPEDPQERGA    50
    IQSELMEITG SPISTTVLTS VSEDSRGQFE NSVLQLREQD ESEMTLSLGN 100
    SNTVDGENTN GPEDIKIQFS RSGSGSGGFL EGLFGCLRPV WNIIGKAYST 150
    DYKLQQQDTW EVPFEEISEL QWLGSGAQGA VFLGKFRAEE VAIKKVREQN 200
    ETDIKHLRKL KHPNIIAFKG VCTQAPCYCI IMEYCAHGQL YEVLRAGRKI 250
    TPRLLVDWST GIASGMNYLH LHKIIHRDLK SPNVLVTHTD AVKISDFGTS 300
    KELSDKSTKM SFAGTVAWMA PEVIRNEPVS EKVDIWSFGV VLWELLTGEI 350
    PYKDVDSSAI IWGVGSNSLH LPVPSTCPDG FKILMKQTWQ SKPRNRPSFR 400
    QTLMHLDIAS ADVLATPQET YFKSQAEWRE EVKKHFEKIK SEGTCIHRLD 450
    EELIRRRREE LRHALDIREH YERKLERANN LYMELSAIML QLEMREKELL 500
    KREQAVEKKY PGTYKRHPVR PIIHPNAMEK LMKRKGVPHK AGVQTKRPDL 550
    LRSEGIPSTE AVPTASPLSG SPKMSTASSR SRYRSKPRHR RGNSRGSHSD 600
    FAAILKTQPA QENSPHPTYM HHTQAQCASV HQHNPLQQQY QQIPPAQPQS 650
    RHPRLNAHGQ DIATCANNLR YFGPAAALRS PLSNHAQRQM PGSSPDLIST 700
    AMAADWRNSE LDQDQVGPWG CCQAEPYDPC FQCRPEHSGS LDVPTTEPVG 750
    RSPDLSSSPA HNPLSGNAQG SERTGANGFS GCQSGISHQF TPPMLPQKTR 800
    PLQKSGDDSS EEEGEVDSEV EFPRRQRPHR CISSYQSYST FSSENFSVSD 850
    GEEGNTSDHS NSPDESANRR QDRLAETLDD LLSQTPEAPI EISSHSDGLS 900
    DKECAVRRVK TQMSLGKLCA EERGYENPVQ FGDSDCDSSE GECSDATVRT 950
    SKNYSSATW 959
    Length:959
    Mass (Da):106,987
    Last modified:June 13, 2006 - v1
    Checksum:i18424BA1695DEDAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ480427 mRNA. Translation: ABF19581.1.
    AK051378 mRNA. Translation: BAC34618.1.
    CCDSiCCDS37294.1.
    RefSeqiNP_766409.2. NM_172821.3.
    XP_006522645.1. XM_006522582.1.
    XP_006522646.1. XM_006522583.1.
    XP_006522647.1. XM_006522584.1.
    UniGeneiMm.420837.
    Mm.438136.

    Genome annotation databases

    EnsembliENSMUST00000042065; ENSMUSP00000047388; ENSMUSG00000033618.
    GeneIDi71751.
    KEGGimmu:71751.
    UCSCiuc007yrr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ480427 mRNA. Translation: ABF19581.1 .
    AK051378 mRNA. Translation: BAC34618.1 .
    CCDSi CCDS37294.1.
    RefSeqi NP_766409.2. NM_172821.3.
    XP_006522645.1. XM_006522582.1.
    XP_006522646.1. XM_006522583.1.
    XP_006522647.1. XM_006522584.1.
    UniGenei Mm.420837.
    Mm.438136.

    3D structure databases

    ProteinModelPortali Q1HKZ5.
    SMRi Q1HKZ5. Positions 111-504.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000047388.

    PTM databases

    PhosphoSitei Q1HKZ5.

    Proteomic databases

    PaxDbi Q1HKZ5.
    PRIDEi Q1HKZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042065 ; ENSMUSP00000047388 ; ENSMUSG00000033618 .
    GeneIDi 71751.
    KEGGi mmu:71751.
    UCSCi uc007yrr.2. mouse.

    Organism-specific databases

    CTDi 9175.
    MGIi MGI:2444243. Map3k13.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117464.
    HOGENOMi HOG000113435.
    HOVERGENi HBG052383.
    InParanoidi Q1HKZ5.
    KOi K04422.
    OMAi HRRGNSR.
    OrthoDBi EOG7B8S3P.
    PhylomeDBi Q1HKZ5.
    TreeFami TF105119.

    Miscellaneous databases

    NextBioi 334401.
    PROi Q1HKZ5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q1HKZ5.
    CleanExi MM_MAP3K13.
    Genevestigatori Q1HKZ5.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR017419. MAP3K12_MAP3K13.
    IPR027258. MAPKKK13.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
    PIRSF500742. MAPKKK13. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Itoh A., Itoh T.
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 690-959.
      Strain: C57BL/6J.
      Tissue: Spinal ganglion.

    Entry informationi

    Entry nameiM3K13_MOUSE
    AccessioniPrimary (citable) accession number: Q1HKZ5
    Secondary accession number(s): Q8BKN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3