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Q1HKZ5 (M3K13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase kinase kinase 13

EC=2.7.11.25
Gene names
Name:Map3k13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length959 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by autophosphorylation and homodimerization By similarity.

Subunit structure

Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain.

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein By similarity.

Post-translational modification

Autophosphorylated on serine and threonine residues By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 959959Mitogen-activated protein kinase kinase kinase 13
PRO_0000277591

Regions

Domain167 – 408242Protein kinase
Nucleotide binding173 – 1819ATP By similarity
Region432 – 45322Leucine-zipper 1
Region485 – 50622Leucine-zipper 2

Sites

Active site2781Proton acceptor By similarity
Binding site1941ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1HKZ5 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 18424BA1695DEDAE

FASTA959106,987
        10         20         30         40         50         60 
MANPQEHLSC SSLPHLPLTE NKTSGGRNEL AAMGNHPSPK LPEDPQERGA IQSELMEITG 

        70         80         90        100        110        120 
SPISTTVLTS VSEDSRGQFE NSVLQLREQD ESEMTLSLGN SNTVDGENTN GPEDIKIQFS 

       130        140        150        160        170        180 
RSGSGSGGFL EGLFGCLRPV WNIIGKAYST DYKLQQQDTW EVPFEEISEL QWLGSGAQGA 

       190        200        210        220        230        240 
VFLGKFRAEE VAIKKVREQN ETDIKHLRKL KHPNIIAFKG VCTQAPCYCI IMEYCAHGQL 

       250        260        270        280        290        300 
YEVLRAGRKI TPRLLVDWST GIASGMNYLH LHKIIHRDLK SPNVLVTHTD AVKISDFGTS 

       310        320        330        340        350        360 
KELSDKSTKM SFAGTVAWMA PEVIRNEPVS EKVDIWSFGV VLWELLTGEI PYKDVDSSAI 

       370        380        390        400        410        420 
IWGVGSNSLH LPVPSTCPDG FKILMKQTWQ SKPRNRPSFR QTLMHLDIAS ADVLATPQET 

       430        440        450        460        470        480 
YFKSQAEWRE EVKKHFEKIK SEGTCIHRLD EELIRRRREE LRHALDIREH YERKLERANN 

       490        500        510        520        530        540 
LYMELSAIML QLEMREKELL KREQAVEKKY PGTYKRHPVR PIIHPNAMEK LMKRKGVPHK 

       550        560        570        580        590        600 
AGVQTKRPDL LRSEGIPSTE AVPTASPLSG SPKMSTASSR SRYRSKPRHR RGNSRGSHSD 

       610        620        630        640        650        660 
FAAILKTQPA QENSPHPTYM HHTQAQCASV HQHNPLQQQY QQIPPAQPQS RHPRLNAHGQ 

       670        680        690        700        710        720 
DIATCANNLR YFGPAAALRS PLSNHAQRQM PGSSPDLIST AMAADWRNSE LDQDQVGPWG 

       730        740        750        760        770        780 
CCQAEPYDPC FQCRPEHSGS LDVPTTEPVG RSPDLSSSPA HNPLSGNAQG SERTGANGFS 

       790        800        810        820        830        840 
GCQSGISHQF TPPMLPQKTR PLQKSGDDSS EEEGEVDSEV EFPRRQRPHR CISSYQSYST 

       850        860        870        880        890        900 
FSSENFSVSD GEEGNTSDHS NSPDESANRR QDRLAETLDD LLSQTPEAPI EISSHSDGLS 

       910        920        930        940        950 
DKECAVRRVK TQMSLGKLCA EERGYENPVQ FGDSDCDSSE GECSDATVRT SKNYSSATW 

« Hide

References

« Hide 'large scale' references
[1]Itoh A., Itoh T.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 690-959.
Strain: C57BL/6J.
Tissue: Spinal ganglion.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ480427 mRNA. Translation: ABF19581.1.
AK051378 mRNA. Translation: BAC34618.1.
RefSeqNP_766409.2. NM_172821.3.
XP_006522645.1. XM_006522582.1.
XP_006522646.1. XM_006522583.1.
XP_006522647.1. XM_006522584.1.
UniGeneMm.420837.
Mm.438136.

3D structure databases

ProteinModelPortalQ1HKZ5.
SMRQ1HKZ5. Positions 111-504.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000047388.

PTM databases

PhosphoSiteQ1HKZ5.

Proteomic databases

PaxDbQ1HKZ5.
PRIDEQ1HKZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042065; ENSMUSP00000047388; ENSMUSG00000033618.
GeneID71751.
KEGGmmu:71751.
UCSCuc007yrr.2. mouse.

Organism-specific databases

CTD9175.
MGIMGI:2444243. Map3k13.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117464.
HOGENOMHOG000113435.
HOVERGENHBG052383.
InParanoidQ1HKZ5.
KOK04422.
OMAHRRGNSR.
OrthoDBEOG7B8S3P.
PhylomeDBQ1HKZ5.
TreeFamTF105119.

Gene expression databases

BgeeQ1HKZ5.
CleanExMM_MAP3K13.
GenevestigatorQ1HKZ5.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR017419. MAP3K12_MAP3K13.
IPR027258. MAPKKK13.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
PIRSF500742. MAPKKK13. 1 hit.
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio334401.
PROQ1HKZ5.
SOURCESearch...

Entry information

Entry nameM3K13_MOUSE
AccessionPrimary (citable) accession number: Q1HKZ5
Secondary accession number(s): Q8BKN0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 13, 2006
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot