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Q1HKZ5

- M3K13_MOUSE

UniProt

Q1HKZ5 - M3K13_MOUSE

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Protein

Mitogen-activated protein kinase kinase kinase 13

Gene

Map3k13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by autophosphorylation and homodimerization.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941ATPPROSITE-ProRule annotation
Active sitei278 – 2781Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi173 – 1819ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. JNK cascade Source: Ensembl
  2. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  3. protein autophosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 13 (EC:2.7.11.25)
Gene namesi
Name:Map3k13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2444243. Map3k13.

Subcellular locationi

Cytoplasm. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. IkappaB kinase complex Source: Ensembl
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Mitogen-activated protein kinase kinase kinase 13PRO_0000277591Add
BLAST

Post-translational modificationi

Autophosphorylated on serine and threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ1HKZ5.
PaxDbiQ1HKZ5.
PRIDEiQ1HKZ5.

PTM databases

PhosphoSiteiQ1HKZ5.

Expressioni

Gene expression databases

BgeeiQ1HKZ5.
CleanExiMM_MAP3K13.
GenevestigatoriQ1HKZ5.

Interactioni

Subunit structurei

Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047388.

Structurei

3D structure databases

ProteinModelPortaliQ1HKZ5.
SMRiQ1HKZ5. Positions 111-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 408242Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni432 – 45322Leucine-zipper 1Add
BLAST
Regioni485 – 50622Leucine-zipper 2Add
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118807.
HOGENOMiHOG000113435.
HOVERGENiHBG052383.
InParanoidiQ1HKZ5.
KOiK04422.
OMAiHRRGNSR.
OrthoDBiEOG7B8S3P.
PhylomeDBiQ1HKZ5.
TreeFamiTF105119.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR017419. MAP3K12_MAP3K13.
IPR027258. MAPKKK13.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
PIRSF500742. MAPKKK13. 1 hit.
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1HKZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANPQEHLSC SSLPHLPLTE NKTSGGRNEL AAMGNHPSPK LPEDPQERGA
60 70 80 90 100
IQSELMEITG SPISTTVLTS VSEDSRGQFE NSVLQLREQD ESEMTLSLGN
110 120 130 140 150
SNTVDGENTN GPEDIKIQFS RSGSGSGGFL EGLFGCLRPV WNIIGKAYST
160 170 180 190 200
DYKLQQQDTW EVPFEEISEL QWLGSGAQGA VFLGKFRAEE VAIKKVREQN
210 220 230 240 250
ETDIKHLRKL KHPNIIAFKG VCTQAPCYCI IMEYCAHGQL YEVLRAGRKI
260 270 280 290 300
TPRLLVDWST GIASGMNYLH LHKIIHRDLK SPNVLVTHTD AVKISDFGTS
310 320 330 340 350
KELSDKSTKM SFAGTVAWMA PEVIRNEPVS EKVDIWSFGV VLWELLTGEI
360 370 380 390 400
PYKDVDSSAI IWGVGSNSLH LPVPSTCPDG FKILMKQTWQ SKPRNRPSFR
410 420 430 440 450
QTLMHLDIAS ADVLATPQET YFKSQAEWRE EVKKHFEKIK SEGTCIHRLD
460 470 480 490 500
EELIRRRREE LRHALDIREH YERKLERANN LYMELSAIML QLEMREKELL
510 520 530 540 550
KREQAVEKKY PGTYKRHPVR PIIHPNAMEK LMKRKGVPHK AGVQTKRPDL
560 570 580 590 600
LRSEGIPSTE AVPTASPLSG SPKMSTASSR SRYRSKPRHR RGNSRGSHSD
610 620 630 640 650
FAAILKTQPA QENSPHPTYM HHTQAQCASV HQHNPLQQQY QQIPPAQPQS
660 670 680 690 700
RHPRLNAHGQ DIATCANNLR YFGPAAALRS PLSNHAQRQM PGSSPDLIST
710 720 730 740 750
AMAADWRNSE LDQDQVGPWG CCQAEPYDPC FQCRPEHSGS LDVPTTEPVG
760 770 780 790 800
RSPDLSSSPA HNPLSGNAQG SERTGANGFS GCQSGISHQF TPPMLPQKTR
810 820 830 840 850
PLQKSGDDSS EEEGEVDSEV EFPRRQRPHR CISSYQSYST FSSENFSVSD
860 870 880 890 900
GEEGNTSDHS NSPDESANRR QDRLAETLDD LLSQTPEAPI EISSHSDGLS
910 920 930 940 950
DKECAVRRVK TQMSLGKLCA EERGYENPVQ FGDSDCDSSE GECSDATVRT

SKNYSSATW
Length:959
Mass (Da):106,987
Last modified:June 13, 2006 - v1
Checksum:i18424BA1695DEDAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ480427 mRNA. Translation: ABF19581.1.
AK051378 mRNA. Translation: BAC34618.1.
CCDSiCCDS37294.1.
RefSeqiNP_766409.2. NM_172821.3.
XP_006522645.1. XM_006522582.1.
XP_006522646.1. XM_006522583.1.
XP_006522647.1. XM_006522584.1.
UniGeneiMm.420837.
Mm.438136.

Genome annotation databases

EnsembliENSMUST00000042065; ENSMUSP00000047388; ENSMUSG00000033618.
GeneIDi71751.
KEGGimmu:71751.
UCSCiuc007yrr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ480427 mRNA. Translation: ABF19581.1 .
AK051378 mRNA. Translation: BAC34618.1 .
CCDSi CCDS37294.1.
RefSeqi NP_766409.2. NM_172821.3.
XP_006522645.1. XM_006522582.1.
XP_006522646.1. XM_006522583.1.
XP_006522647.1. XM_006522584.1.
UniGenei Mm.420837.
Mm.438136.

3D structure databases

ProteinModelPortali Q1HKZ5.
SMRi Q1HKZ5. Positions 111-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000047388.

PTM databases

PhosphoSitei Q1HKZ5.

Proteomic databases

MaxQBi Q1HKZ5.
PaxDbi Q1HKZ5.
PRIDEi Q1HKZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042065 ; ENSMUSP00000047388 ; ENSMUSG00000033618 .
GeneIDi 71751.
KEGGi mmu:71751.
UCSCi uc007yrr.2. mouse.

Organism-specific databases

CTDi 9175.
MGIi MGI:2444243. Map3k13.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118807.
HOGENOMi HOG000113435.
HOVERGENi HBG052383.
InParanoidi Q1HKZ5.
KOi K04422.
OMAi HRRGNSR.
OrthoDBi EOG7B8S3P.
PhylomeDBi Q1HKZ5.
TreeFami TF105119.

Miscellaneous databases

NextBioi 334401.
PROi Q1HKZ5.
SOURCEi Search...

Gene expression databases

Bgeei Q1HKZ5.
CleanExi MM_MAP3K13.
Genevestigatori Q1HKZ5.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR017419. MAP3K12_MAP3K13.
IPR027258. MAPKKK13.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
PIRSF500742. MAPKKK13. 1 hit.
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Itoh A., Itoh T.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 690-959.
    Strain: C57BL/6J.
    Tissue: Spinal ganglion.

Entry informationi

Entry nameiM3K13_MOUSE
AccessioniPrimary (citable) accession number: Q1HKZ5
Secondary accession number(s): Q8BKN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 13, 2006
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3