Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1HKA1

- COX1_CANLU

UniProt

Q1HKA1 - COX1_CANLU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Canis lupus (Gray wolf)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand)Curated
Metal bindingi244 – 2441Copper BCurated
Metal bindingi290 – 2901Copper BCurated
Metal bindingi291 – 2911Copper BCurated
Metal bindingi376 – 3761Iron (heme A3 axial ligand)Curated
Metal bindingi378 – 3781Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiCanis lupus (Gray wolf)
Taxonomic identifieri9612 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei12 – 4029Helical; Name=IBy similarityAdd
BLAST
Topological domaini41 – 5010Mitochondrial intermembraneBy similarity
Transmembranei51 – 8636Helical; Name=IIBy similarityAdd
BLAST
Topological domaini87 – 948Mitochondrial matrixBy similarity
Transmembranei95 – 11723Helical; Name=IIIBy similarityAdd
BLAST
Topological domaini118 – 14023Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei141 – 17030Helical; Name=IVBy similarityAdd
BLAST
Topological domaini171 – 18212Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei183 – 21230Helical; Name=VBy similarityAdd
BLAST
Topological domaini213 – 22715Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei228 – 26134Helical; Name=VIBy similarityAdd
BLAST
Topological domaini262 – 2698Mitochondrial matrixBy similarity
Transmembranei270 – 28617Helical; Name=VIIBy similarityAdd
BLAST
Topological domaini287 – 29812Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei299 – 32729Helical; Name=VIIIBy similarityAdd
BLAST
Topological domaini328 – 3358Mitochondrial matrixBy similarity
Transmembranei336 – 35722Helical; Name=IXBy similarityAdd
BLAST
Topological domaini358 – 37013Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei371 – 40030Helical; Name=XBy similarityAdd
BLAST
Topological domaini401 – 4066Mitochondrial matrixBy similarity
Transmembranei407 – 43327Helical; Name=XIBy similarityAdd
BLAST
Topological domaini434 – 44613Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei447 – 47832Helical; Name=XIIBy similarityAdd
BLAST
Topological domaini479 – 51436Mitochondrial matrixBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000269704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1HKA1.
SMRiQ1HKA1. Positions 1-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003841.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1HKA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD
60 70 80 90 100
DQIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM
110 120 130 140 150
SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL
160 170 180 190 200
HLAGVSSILG AINFITTIIN MKPPAMSQYQ TPLFVWSVLI TAVLLLLSLP
210 220 230 240 250
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG
260 270 280 290 300
FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD
310 320 330 340 350
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV
360 370 380 390 400
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFAHWFPLF
410 420 430 440 450
SGYTLNDTWA KIHFTIMFVG VNMTFFPQHF LGLSGMPRRY SDYPDAYTTW
460 470 480 490 500
NTVSSMGSFI SLTAVMLMIF MIWEAFASKR EVAMVELTTT NIEWLHGCPP
510
PYHTFEEPTY VIQK
Length:514
Mass (Da):57,039
Last modified:June 13, 2006 - v1
Checksum:i44D2B3E8E04CBF6F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti512 – 5121I → V.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598496 Genomic DNA. Translation: AAU00442.1.
DQ480503 Genomic DNA. Translation: ABE48157.1.
DQ480504 Genomic DNA. Translation: ABE48170.1.
DQ480505 Genomic DNA. Translation: ABE48183.1.
DQ480506 Genomic DNA. Translation: ABE48196.1.
DQ480507 Genomic DNA. Translation: ABE48209.1.
DQ480508 Genomic DNA. Translation: ABE48222.1.
RefSeqiYP_626730.1. NC_008092.1.

Genome annotation databases

GeneIDi4097766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598496 Genomic DNA. Translation: AAU00442.1 .
DQ480503 Genomic DNA. Translation: ABE48157.1 .
DQ480504 Genomic DNA. Translation: ABE48170.1 .
DQ480505 Genomic DNA. Translation: ABE48183.1 .
DQ480506 Genomic DNA. Translation: ABE48196.1 .
DQ480507 Genomic DNA. Translation: ABE48209.1 .
DQ480508 Genomic DNA. Translation: ABE48222.1 .
RefSeqi YP_626730.1. NC_008092.1.

3D structure databases

ProteinModelPortali Q1HKA1.
SMRi Q1HKA1. Positions 1-511.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4097766.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

HOVERGENi HBG003841.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A phylogeny of the Caniformia (order Carnivora) based on 12 complete protein-coding mitochondrial genes."
    Delisle I., Strobeck C.
    Mol. Phylogenet. Evol. 37:192-201(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-512.
  2. "Relaxation of selective constraint on dog mitochondrial DNA following domestication."
    Bjornerfeldt S., Webster M.T., Vila C.
    Genome Res. 16:990-994(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-512.

Entry informationi

Entry nameiCOX1_CANLU
AccessioniPrimary (citable) accession number: Q1HKA1
Secondary accession number(s): Q3L6Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3