Reviewed, UniProtKB/Swiss-Prot Q1HG44 (DOXA2_HUMAN)

Names and origin

Protein names

Recommended name:
    Dual oxidase maturation factor 2
Alternative name(s):
    Dual oxidase activator 2

Gene names

Name:

DUOXA2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis. Ref.1
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Ref.1
Tissue specificity	Specifically expressed in thyroid. Also detected in salivary glands. Ref.1
Post-translational modification	N-glycosylated. Ref.1
Sequence similarities	Belongs to the DUOXA family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Dual oxidase maturation factor 2		PRO_0000264245
Regions
	Topological domain	1 – 21	21	Extracellular Potential
	Transmembrane	22 – 42	21	Potential
	Topological domain	43 – 56	14	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Potential
	Topological domain	78 – 183	106	Extracellular Potential
	Transmembrane	184 – 204	21	Potential
	Topological domain	205 – 206	2	Cytoplasmic Potential
	Transmembrane	207 – 227	21	Potential
	Topological domain	228 – 247	20	Extracellular Potential
	Transmembrane	248 – 268	21	Potential
	Topological domain	269 – 320	52	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	109	1	N-linked (GlcNAc...) Potential
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	100	1	R → G: dbSNP rs2576090. Ref.1		VAR_047367

Sequences

	Sequence		Length	Mass (Da)
	Q1HG44-1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 5B2F58E575A30E72	FASTA	320	34,787
	10 20 30 40 50 60 MTLWNGVLPF YPQPRHAAGF SVPLLIVILV FLALAASFLL ILPGIRGHSR WFWLVRVLLS 70 80 90 100 110 120 LFIGAEIVAV HFSAEWFVGT VNTNTSYKAF SAARVTARVR LLVGLEGINI TLTGTPVHQL 130 140 150 160 170 180 NETIDYNEQF TWRLKENYAA EYANALEKGL PDPVLYLAEK FTPSSPCGLY HQYHLAGHYA 190 200 210 220 230 240 SATLWVAFCF WLLSNVLLST PAPLYGGLAL LTTGAFALFG VFALASISSV PLCPLRLGSS 250 260 270 280 290 300 ALTTQYGAAF WVTLATGVLC LFLGGAVVSL QYVRPSALRT LLDQSAKDCS QERGGSPLIL 310 320 GDPLHKQAAL PDLKCITTNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent." Grasberger H., Refetoff S. J. Biol. Chem. 281:18269-18272(2006) [PubMed: 16651268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GLYCOSYLATION, VARIANT GLY-100. Tissue: Thyroid.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ489734 mRNA. Translation: ABF48256.1. AC091117 Genomic DNA. No translation available. BC137465 mRNA. Translation: AAI37466.1.
IPI	IPI00183661.
RefSeq	NP_997464.2.
UniGene	Hs.497987
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000140274. Homo sapiens. [Contig view]
GeneID	405753.
KEGG	hsa:405753.
Organism-specific databases
GeneCards	GC15P043194.
HGNC	HGNC:32698. DUOXA2.
Orphanet	442. Hypothyroidism, congenital. 95717. Hypothyroidism, congenital idiopathic.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q1HG44.
OMA	Q1HG44. VPLCPLR.
Gene expression databases
Bgee	Q1HG44.
CleanEx	HS_DUOXA2.
GermOnline	ENSG00000140274. Homo sapiens.
Family and domain databases
InterPro	IPR018469. Dual_oxidase_maturation_fac. [Graphical view]
Pfam	PF10204. DuoxA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	107951.

Entry information

Entry name

DOXA2_HUMAN

Accession

Primary (citable) accession number: Q1HG44
Secondary accession number(s): B2RPI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 25, 2008
Last modified:	June 16, 2009
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)