Reviewed, UniProtKB/Swiss-Prot Q1HG43 (DOXA1_HUMAN)

Names and origin

Protein names

Recommended name:
    Dual oxidase maturation factor 1
Alternative name(s):
    Dual oxidase activator 1
    Numb-interacting protein

Gene names

Name:	DUOXA1
Synonyms:	NIP, NUMBIP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1 Probable.
Subunit structure	May interact with NUMB.
Subcellular location	Membrane; Multi-pass membrane proteinPotential.
Tissue specificity	Specifically expressed in thyroid gland. Also detected in esophagus.
Sequence similarities	Belongs to the DUOXA family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q1HG43-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q1HG43-2)

The sequence of this isoform differs from the canonical sequence as follows:
     331-343: CKEAHPKDPDCAL → YRPRRLSLVP...CVTSRHTPLI

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q1HG43-3)

The sequence of this isoform differs from the canonical sequence as follows:
     69-113: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Dual oxidase maturation factor 1		PRO_0000264241
Regions
	Topological domain	1 – 24	24	Extracellular Potential
	Transmembrane	25 – 45	21	Potential
	Topological domain	46 – 51	6	Cytoplasmic Potential
	Transmembrane	52 – 72	21	Potential
	Topological domain	73 – 183	111	Extracellular Potential
	Transmembrane	184 – 204	21	Potential
	Topological domain	205 – 206	2	Cytoplasmic Potential
	Transmembrane	207 – 227	21	Potential
	Topological domain	228 – 249	22	Extracellular Potential
	Transmembrane	250 – 270	21	Potential
	Topological domain	271 – 343	73	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	109	1	N-linked (GlcNAc...) Potential
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	69 – 113	45	Missing in isoform 3.		VSP_021890
	Alternative sequence	331 – 343	13	CKEAH…PDCAL → YRPRRLSLVPADVRGLAPAA LSALPGALLAQAWRALLPGL RCPKAGKESRLGPPHSPWRF GPEGCEERWAEHTGDSPRPL RGRGTGRLWRWGSKERRACG VRAMLPRLVSNSGLKRPSCL DLPKCWDYRRDARAFFHLLE PTPCVTSRHTPLI in isoform 2.		VSP_021891
	Natural variant	313	1	S → G: dbSNP rs16977686.		VAR_029630

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 38958512200260BE	FASTA	343	37,815
	10 20 30 40 50 60 MATLGHTFPF YAGPKPTFPM DTTLASIIMI FLTALATFIV ILPGIRGKTR LFWLLRVVTS 70 80 90 100 110 120 LFIGAAILAV NFSSEWSVGQ VSTNTSYKAF SSEWISADIG LQVGLGGVNI TLTGTPVQQL 130 140 150 160 170 180 NETINYNEEF TWRLGENYAE EYAKALEKGL PDPVLYLAEK FTPRSPCGLY RQYRLAGHYT 190 200 210 220 230 240 SAMLWVAFLC WLLANVMLSM PVLVYGGYML LATGIFQLLA LLFFSMATSL TSPCPLHLGA 250 260 270 280 290 300 SVLHTHHGPA FWITLTTGLL CVLLGLAMAV AHRMQPHRLK AFFNQSVDED PMLEWSPEEG 310 320 330 340 GLLSPRYRSM ADSPKSQDIP LSEASSTKAY CKEAHPKDPD CAL
	Isoform 2 [UniParc]. Checksum: 54BEF64528B96C18		483	53,519
	10 20 30 40 50 60 MATLGHTFPF YAGPKPTFPM DTTLASIIMI FLTALATFIV ILPGIRGKTR LFWLLRVVTS 70 80 90 100 110 120 LFIGAAILAV NFSSEWSVGQ VSTNTSYKAF SSEWISADIG LQVGLGGVNI TLTGTPVQQL 130 140 150 160 170 180 NETINYNEEF TWRLGENYAE EYAKALEKGL PDPVLYLAEK FTPRSPCGLY RQYRLAGHYT 190 200 210 220 230 240 SAMLWVAFLC WLLANVMLSM PVLVYGGYML LATGIFQLLA LLFFSMATSL TSPCPLHLGA 250 260 270 280 290 300 SVLHTHHGPA FWITLTTGLL CVLLGLAMAV AHRMQPHRLK AFFNQSVDED PMLEWSPEEG 310 320 330 340 350 360 GLLSPRYRSM ADSPKSQDIP LSEASSTKAY YRPRRLSLVP ADVRGLAPAA LSALPGALLA 370 380 390 400 410 420 QAWRALLPGL RCPKAGKESR LGPPHSPWRF GPEGCEERWA EHTGDSPRPL RGRGTGRLWR 430 440 450 460 470 480 WGSKERRACG VRAMLPRLVS NSGLKRPSCL DLPKCWDYRR DARAFFHLLE PTPCVTSRHT PLI
	Isoform 3 [UniParc]. Checksum: D9B346C25D142E1D		298	33,111
	10 20 30 40 50 60 MATLGHTFPF YAGPKPTFPM DTTLASIIMI FLTALATFIV ILPGIRGKTR LFWLLRVVTS 70 80 90 100 110 120 LFIGAAILGT PVQQLNETIN YNEEFTWRLG ENYAEEYAKA LEKGLPDPVL YLAEKFTPRS 130 140 150 160 170 180 PCGLYRQYRL AGHYTSAMLW VAFLCWLLAN VMLSMPVLVY GGYMLLATGI FQLLALLFFS 190 200 210 220 230 240 MATSLTSPCP LHLGASVLHT HHGPAFWITL TTGLLCVLLG LAMAVAHRMQ PHRLKAFFNQ 250 260 270 280 290 SVDEDPMLEW SPEEGGLLSP RYRSMADSPK SQDIPLSEAS STKAYCKEAH PKDPDCAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent." Grasberger H., Refetoff S. J. Biol. Chem. 281:18269-18272(2006) [PubMed: 16651268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Thyroid.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Prostate.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Lung.
[4]	"A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division." Qin H., Percival-Smith A., Li C., Jia C.Y.H., Gloor G., Li S.S.-C. J. Biol. Chem. 279:11304-11312(2004) [PubMed: 14670962] [Abstract] Cited for: INTERACTION WITH NUMB.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ489735 mRNA. Translation: ABF48257.1. AK056896 mRNA. Translation: BAB71304.1. BC020841 mRNA. Translation: AAH20841.1. BC029819 mRNA. Translation: AAH29819.1.
RefSeq	NP_653166.2.
UniGene	Hs.356664
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000140254. Homo sapiens. [Contig view]
GeneID	90527.
KEGG	hsa:90527.
Organism-specific databases
HGNC	HGNC:26507. DUOXA1.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q1HG43.
Gene expression databases
CleanEx	HS_DUOXA1.
GermOnline	ENSG00000140254. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	76821.

Entry information

Entry name

DOXA1_HUMAN

Accession

Primary (citable) accession number: Q1HG43
Secondary accession number(s): Q8N6K9, Q96MI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	June 13, 2006
Last modified:	November 4, 2008
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)