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Protein

Zinc finger and BTB domain-containing protein 48

Gene

Zbtb48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and regulates the J and/or S elements in MHC II promoter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri284 – 306C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 394C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri400 – 423C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri429 – 452C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri458 – 480C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 537C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri543 – 565C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 48
Alternative name(s):
Krueppel-related zinc finger protein 3
Protein HKR3
Gene namesi
Name:Zbtb48
Synonyms:Hkr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140248. Zbtb48.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002921361 – 681Zinc finger and BTB domain-containing protein 48Add BLAST681

Proteomic databases

PaxDbiQ1H9T6.
PeptideAtlasiQ1H9T6.
PRIDEiQ1H9T6.

PTM databases

PhosphoSitePlusiQ1H9T6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028952.
CleanExiMM_ZBTB48.
ExpressionAtlasiQ1H9T6. baseline and differential.
GenevisibleiQ1H9T6. MM.

Interactioni

Protein-protein interaction databases

BioGridi221379. 31 interactors.
IntActiQ1H9T6. 30 interactors.
STRINGi10090.ENSMUSP00000067521.

Structurei

Secondary structure

1681
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 21Combined sources14
Turni22 – 25Combined sources4
Beta strandi28 – 32Combined sources5
Beta strandi35 – 39Combined sources5
Helixi41 – 47Combined sources7
Helixi49 – 53Combined sources5
Beta strandi63 – 65Combined sources3
Helixi67 – 69Combined sources3
Helixi70 – 82Combined sources13
Turni89 – 91Combined sources3
Helixi92 – 101Combined sources10
Helixi105 – 113Combined sources9
Turni287 – 289Combined sources3
Helixi296 – 306Combined sources11
Turni315 – 317Combined sources3
Helixi324 – 333Combined sources10
Beta strandi346 – 348Combined sources3
Beta strandi351 – 354Combined sources4
Helixi355 – 365Combined sources11
Beta strandi366 – 368Combined sources3
Beta strandi370 – 372Combined sources3
Beta strandi374 – 376Combined sources3
Beta strandi379 – 382Combined sources4
Helixi383 – 392Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLQNMR-A284-394[»]
2YY9X-ray2.60A/B8-129[»]
ProteinModelPortaliQ1H9T6.
SMRiQ1H9T6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ1H9T6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 89BTBPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri284 – 306C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 394C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri400 – 423C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri429 – 452C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri458 – 480C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 537C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri543 – 565C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133800.
HOGENOMiHOG000049146.
HOVERGENiHBG000087.
InParanoidiQ1H9T6.
KOiK10519.
OMAiNVIRKPC.
OrthoDBiEOG091G02KC.
TreeFamiTF331310.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1H9T6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF
60 70 80 90 100
FQRIYGDGTG GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAK
110 120 130 140 150
ELRVPEAVEL CQSFQPQTSV GQAQSGLGQP ASQDVKSHLK EPTDLDEEEV
160 170 180 190 200
FRTLSLASVD QEPRDTEQPQ LGTPAQSTTA FLCGKLTQAL KPSPSEDKES
210 220 230 240 250
EDCKEPPRPF EAGGAPLQGE SNEWEVVVQV EDDRDGDYVS EPETVLTRRK
260 270 280 290 300
SKVIRKPCAA EPALGAGSLT AEPTDSRKGA AVPVECPTCH KKFLSKYYLK
310 320 330 340 350
VHNRKHTGEK PFECPKCGKC YFRKENLLEH EARNCMNRSE QVFTCSVCQE
360 370 380 390 400
TFRRRMELRL HMVSHTGEMP YKCSSCSQQF MQKKDLQSHM IKLHGAPKPH
410 420 430 440 450
ACPTCAKCFL SRTELQLHEA FKHRGEKLFV CEECGHRASS RNGLQMHIKA
460 470 480 490 500
KHRNERPYVC EFCSHAFTQK ANLNMHLRTH TGEKPFQCHL CGKTFRTQAS
510 520 530 540 550
LDKHNRTHTG ERPFSCEFCE QRFTEKGPLL RHVASRHQEG RPHFCQICGK
560 570 580 590 600
TFKAVEQLRV HVRRHKGVRK FECTECGYKF TRQAHLRRHM EIHDRVENYN
610 620 630 640 650
PRQRKLRNLI IEDEKMVVVA LQPPADLEVG SAEVIVESLT QGGLASQLPS
660 670 680
QRLCSEESFA SPGVLEPSLI ITAAVPEDCD T
Length:681
Mass (Da):76,800
Last modified:June 27, 2006 - v1
Checksum:iCA2480B57098CCB3
GO
Isoform 2 (identifier: Q1H9T6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-681: CPTCAKCFLS...TAAVPEDCDT → VSASQGWGSG...HPHGREAFQL

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:547
Mass (Da):59,473
Checksum:i0339BC0A2503CD59
GO

Sequence cautioni

The sequence CAM24576 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152R → K in AAH05515 (PubMed:15489334).Curated1
Sequence conflicti178T → S in AAH05515 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q1H9T6-2)
Sequence conflicti476D → G in AAH05515 (PubMed:15489334).Curated1
Sequence conflicti512H → R in AAH05515 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026381402 – 681CPTCA…EDCDT → VSASQGWGSGGSGTAQSCPH LDVLPLPVSPTCSAPLVPSA SCLGRSYSCTRLLSIVEKSS LCVRNAGTGPRAATDCRCTS RPSTGMKGLMSVSSAAMPSP RRPTSTCTCAHTPARSLSSA TSVGRPSAPKFGQAQPHPHG REAFQL in isoform 2. 1 PublicationAdd BLAST280

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM161454 mRNA. Translation: CAJ44110.1.
AL611927 Genomic DNA. Translation: CAM24576.2. Sequence problems.
BC005515 mRNA. Translation: AAH05515.1.
CCDSiCCDS38982.1. [Q1H9T6-1]
RefSeqiNP_598640.2. NM_133879.2. [Q1H9T6-1]
UniGeneiMm.24661.

Genome annotation databases

EnsembliENSMUST00000066715; ENSMUSP00000067521; ENSMUSG00000028952. [Q1H9T6-1]
ENSMUST00000155389; ENSMUSP00000114726; ENSMUSG00000028952. [Q1H9T6-2]
GeneIDi100090.
KEGGimmu:100090.
UCSCiuc008vyz.1. mouse. [Q1H9T6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM161454 mRNA. Translation: CAJ44110.1.
AL611927 Genomic DNA. Translation: CAM24576.2. Sequence problems.
BC005515 mRNA. Translation: AAH05515.1.
CCDSiCCDS38982.1. [Q1H9T6-1]
RefSeqiNP_598640.2. NM_133879.2. [Q1H9T6-1]
UniGeneiMm.24661.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLQNMR-A284-394[»]
2YY9X-ray2.60A/B8-129[»]
ProteinModelPortaliQ1H9T6.
SMRiQ1H9T6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221379. 31 interactors.
IntActiQ1H9T6. 30 interactors.
STRINGi10090.ENSMUSP00000067521.

PTM databases

PhosphoSitePlusiQ1H9T6.

Proteomic databases

PaxDbiQ1H9T6.
PeptideAtlasiQ1H9T6.
PRIDEiQ1H9T6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066715; ENSMUSP00000067521; ENSMUSG00000028952. [Q1H9T6-1]
ENSMUST00000155389; ENSMUSP00000114726; ENSMUSG00000028952. [Q1H9T6-2]
GeneIDi100090.
KEGGimmu:100090.
UCSCiuc008vyz.1. mouse. [Q1H9T6-1]

Organism-specific databases

CTDi3104.
MGIiMGI:2140248. Zbtb48.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133800.
HOGENOMiHOG000049146.
HOVERGENiHBG000087.
InParanoidiQ1H9T6.
KOiK10519.
OMAiNVIRKPC.
OrthoDBiEOG091G02KC.
TreeFamiTF331310.

Miscellaneous databases

ChiTaRSiZbtb48. mouse.
EvolutionaryTraceiQ1H9T6.
PROiQ1H9T6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028952.
CleanExiMM_ZBTB48.
ExpressionAtlasiQ1H9T6. baseline and differential.
GenevisibleiQ1H9T6. MM.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT48_MOUSE
AccessioniPrimary (citable) accession number: Q1H9T6
Secondary accession number(s): A2A8B1, Q99K15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.