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Protein

Zinc finger and BTB domain-containing protein 48

Gene

Zbtb48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and regulates the J and/or S elements in MHC II promoter.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri284 – 30623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39424C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42324C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53724C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 48
Alternative name(s):
Krueppel-related zinc finger protein 3
Protein HKR3
Gene namesi
Name:Zbtb48
Synonyms:Hkr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140248. Zbtb48.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681Zinc finger and BTB domain-containing protein 48PRO_0000292136Add
BLAST

Proteomic databases

MaxQBiQ1H9T6.
PaxDbiQ1H9T6.
PeptideAtlasiQ1H9T6.
PRIDEiQ1H9T6.

PTM databases

PhosphoSiteiQ1H9T6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028952.
CleanExiMM_ZBTB48.
ExpressionAtlasiQ1H9T6. baseline and differential.
GenevisibleiQ1H9T6. MM.

Interactioni

Protein-protein interaction databases

BioGridi221379. 31 interactions.
IntActiQ1H9T6. 30 interactions.
STRINGi10090.ENSMUSP00000067521.

Structurei

Secondary structure

1
681
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 2114Combined sources
Turni22 – 254Combined sources
Beta strandi28 – 325Combined sources
Beta strandi35 – 395Combined sources
Helixi41 – 477Combined sources
Helixi49 – 535Combined sources
Beta strandi63 – 653Combined sources
Helixi67 – 693Combined sources
Helixi70 – 8213Combined sources
Turni89 – 913Combined sources
Helixi92 – 10110Combined sources
Helixi105 – 1139Combined sources
Turni287 – 2893Combined sources
Helixi296 – 30611Combined sources
Turni315 – 3173Combined sources
Helixi324 – 33310Combined sources
Beta strandi346 – 3483Combined sources
Beta strandi351 – 3544Combined sources
Helixi355 – 36511Combined sources
Beta strandi366 – 3683Combined sources
Beta strandi370 – 3723Combined sources
Beta strandi374 – 3763Combined sources
Beta strandi379 – 3824Combined sources
Helixi383 – 39210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DLQNMR-A284-394[»]
2YY9X-ray2.60A/B8-129[»]
ProteinModelPortaliQ1H9T6.
SMRiQ1H9T6. Positions 8-114, 284-600.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ1H9T6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 8964BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri284 – 30623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39424C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42324C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53724C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129819.
HOGENOMiHOG000049146.
HOVERGENiHBG000087.
InParanoidiQ1H9T6.
KOiK10519.
OMAiNVIRKPC.
OrthoDBiEOG091G02KC.
TreeFamiTF331310.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1H9T6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF
60 70 80 90 100
FQRIYGDGTG GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAK
110 120 130 140 150
ELRVPEAVEL CQSFQPQTSV GQAQSGLGQP ASQDVKSHLK EPTDLDEEEV
160 170 180 190 200
FRTLSLASVD QEPRDTEQPQ LGTPAQSTTA FLCGKLTQAL KPSPSEDKES
210 220 230 240 250
EDCKEPPRPF EAGGAPLQGE SNEWEVVVQV EDDRDGDYVS EPETVLTRRK
260 270 280 290 300
SKVIRKPCAA EPALGAGSLT AEPTDSRKGA AVPVECPTCH KKFLSKYYLK
310 320 330 340 350
VHNRKHTGEK PFECPKCGKC YFRKENLLEH EARNCMNRSE QVFTCSVCQE
360 370 380 390 400
TFRRRMELRL HMVSHTGEMP YKCSSCSQQF MQKKDLQSHM IKLHGAPKPH
410 420 430 440 450
ACPTCAKCFL SRTELQLHEA FKHRGEKLFV CEECGHRASS RNGLQMHIKA
460 470 480 490 500
KHRNERPYVC EFCSHAFTQK ANLNMHLRTH TGEKPFQCHL CGKTFRTQAS
510 520 530 540 550
LDKHNRTHTG ERPFSCEFCE QRFTEKGPLL RHVASRHQEG RPHFCQICGK
560 570 580 590 600
TFKAVEQLRV HVRRHKGVRK FECTECGYKF TRQAHLRRHM EIHDRVENYN
610 620 630 640 650
PRQRKLRNLI IEDEKMVVVA LQPPADLEVG SAEVIVESLT QGGLASQLPS
660 670 680
QRLCSEESFA SPGVLEPSLI ITAAVPEDCD T
Length:681
Mass (Da):76,800
Last modified:June 27, 2006 - v1
Checksum:iCA2480B57098CCB3
GO
Isoform 2 (identifier: Q1H9T6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-681: CPTCAKCFLS...TAAVPEDCDT → VSASQGWGSG...HPHGREAFQL

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:547
Mass (Da):59,473
Checksum:i0339BC0A2503CD59
GO

Sequence cautioni

The sequence CAM24576 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521R → K in AAH05515 (PubMed:15489334).Curated
Sequence conflicti178 – 1781T → S in AAH05515 (PubMed:15489334).Curated
Isoform 2 (identifier: Q1H9T6-2)
Sequence conflicti476 – 4761D → G in AAH05515 (PubMed:15489334).Curated
Sequence conflicti512 – 5121H → R in AAH05515 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei402 – 681280CPTCA…EDCDT → VSASQGWGSGGSGTAQSCPH LDVLPLPVSPTCSAPLVPSA SCLGRSYSCTRLLSIVEKSS LCVRNAGTGPRAATDCRCTS RPSTGMKGLMSVSSAAMPSP RRPTSTCTCAHTPARSLSSA TSVGRPSAPKFGQAQPHPHG REAFQL in isoform 2. 1 PublicationVSP_026381Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM161454 mRNA. Translation: CAJ44110.1.
AL611927 Genomic DNA. Translation: CAM24576.2. Sequence problems.
BC005515 mRNA. Translation: AAH05515.1.
CCDSiCCDS38982.1. [Q1H9T6-1]
RefSeqiNP_598640.2. NM_133879.2. [Q1H9T6-1]
UniGeneiMm.24661.

Genome annotation databases

EnsembliENSMUST00000066715; ENSMUSP00000067521; ENSMUSG00000028952. [Q1H9T6-1]
ENSMUST00000155389; ENSMUSP00000114726; ENSMUSG00000028952. [Q1H9T6-2]
GeneIDi100090.
KEGGimmu:100090.
UCSCiuc008vyz.1. mouse. [Q1H9T6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM161454 mRNA. Translation: CAJ44110.1.
AL611927 Genomic DNA. Translation: CAM24576.2. Sequence problems.
BC005515 mRNA. Translation: AAH05515.1.
CCDSiCCDS38982.1. [Q1H9T6-1]
RefSeqiNP_598640.2. NM_133879.2. [Q1H9T6-1]
UniGeneiMm.24661.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DLQNMR-A284-394[»]
2YY9X-ray2.60A/B8-129[»]
ProteinModelPortaliQ1H9T6.
SMRiQ1H9T6. Positions 8-114, 284-600.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221379. 31 interactions.
IntActiQ1H9T6. 30 interactions.
STRINGi10090.ENSMUSP00000067521.

PTM databases

PhosphoSiteiQ1H9T6.

Proteomic databases

MaxQBiQ1H9T6.
PaxDbiQ1H9T6.
PeptideAtlasiQ1H9T6.
PRIDEiQ1H9T6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066715; ENSMUSP00000067521; ENSMUSG00000028952. [Q1H9T6-1]
ENSMUST00000155389; ENSMUSP00000114726; ENSMUSG00000028952. [Q1H9T6-2]
GeneIDi100090.
KEGGimmu:100090.
UCSCiuc008vyz.1. mouse. [Q1H9T6-1]

Organism-specific databases

CTDi3104.
MGIiMGI:2140248. Zbtb48.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129819.
HOGENOMiHOG000049146.
HOVERGENiHBG000087.
InParanoidiQ1H9T6.
KOiK10519.
OMAiNVIRKPC.
OrthoDBiEOG091G02KC.
TreeFamiTF331310.

Miscellaneous databases

ChiTaRSiZbtb48. mouse.
EvolutionaryTraceiQ1H9T6.
PROiQ1H9T6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028952.
CleanExiMM_ZBTB48.
ExpressionAtlasiQ1H9T6. baseline and differential.
GenevisibleiQ1H9T6. MM.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT48_MOUSE
AccessioniPrimary (citable) accession number: Q1H9T6
Secondary accession number(s): A2A8B1, Q99K15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 27, 2006
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.