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Q1H8W5

- Q1H8W5_CHIKV

UniProt

Q1H8W5 - Q1H8W5_CHIKV

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Protein
Submitted name:

Structural polyprotein

Gene
N/A
Organism
Chikungunya virus (CHIKV)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Structural polyproteinImported
OrganismiChikungunya virus (CHIKV)Imported
Taxonomic identifieri37124 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTogaviridaeAlphavirusSFV complex
Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) [TaxID: 7160]
Aedes furcifer (Mosquito) [TaxID: 299627]
Aedes polynesiensis (Polynesian tiger mosquito) [TaxID: 188700]
Cercopithecus [TaxID: 9533]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Pan troglodytes (Chimpanzee) [TaxID: 9598]
Papio (baboons) [TaxID: 9554]
Presbytis [TaxID: 9573]

Subcellular locationi

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral capsid Source: UniProtKB-KW
  4. virion membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261capsidImportedPRO_5000079763Add
BLAST
Chaini262 – 32564glycoprotein E3ImportedPRO_5000079764Add
BLAST
Chaini326 – 748423glycoprotein E2ImportedPRO_5000079765Add
BLAST
Chaini749 – 80961glycoprotein 6KImportedPRO_5000079766Add
BLAST
Chaini810 – 1248439glycoprotein E1ImportedPRO_5000079767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi273 – 2731N-linked (GlcNAc...)
Glycosylationi588 – 5881N-linked (GlcNAc...)Imported
Glycosylationi950 – 9501N-linked (GlcNAc...)Imported

Interactioni

Protein-protein interaction databases

DIPiDIP-59506N.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XFBelectron microscopy9.00A/D/F/H810-1200[»]
B/E/G/I333-666[»]
2XFCelectron microscopy9.00A/D/F/H810-1248[»]
B/E/G/I326-748[»]
3J2Welectron microscopy5.00A/B/C/D810-1202[»]
3N40X-ray2.17F810-1200[»]
P266-666[»]
3N41X-ray3.01A262-320[»]
B326-667[»]
F810-1190[»]
3N42X-ray3.00A262-319[»]
B326-667[»]
F810-1202[»]
3N43X-ray2.58A262-318[»]
B326-667[»]
F810-1200[»]
3N44X-ray2.35A262-325[»]
B326-685[»]
F810-1221[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ1H8W5.

Family & Domainsi

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 3 hits.
InterProiIPR002548. Alpha_E1_glycop.
IPR000936. Alpha_E2_glycop.
IPR002533. Alpha_E3_glycop.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014756. Ig_E-set.
IPR000930. Peptidase_S3.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01589. Alpha_E1_glycop. 1 hit.
PF00943. Alpha_E2_glycop. 1 hit.
PF01563. Alpha_E3_glycop. 1 hit.
PF00944. Peptidase_S3. 1 hit.
[Graphical view]
PRINTSiPR00798. TOGAVIRIN.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1H8W5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFIPTQTFY NRRYQPRPWT PRPTIQVIRP RPRPQRQAGQ LAQLISAVNK
60 70 80 90 100
LTMRAVPQQK PRRNRKNKKQ KQKQQAPQNN TNQKKQPPKK KPAQKKKKPG
110 120 130 140 150
RRERMCMKIE NDCIFEVKHE GKVTGYACLV GDKVMKPAHV KGTIDNADLA
160 170 180 190 200
KLAFKRSSKY DLECAQIPVH MKSDASKFTH EKPEGYYNWH HGAVQYSGGR
210 220 230 240 250
FTIPTGAGKP GDSGRPIFDN KGRVVAIVLG GANEGARTAL SVVTWNKDIV
260 270 280 290 300
TKITPEGAEE WSLAIPVMCL LANTTFPCSQ PPCTPCCYEK EPEETLRMLE
310 320 330 340 350
DNVMRPGYYQ LLQASLTCSP HRQRRSTKDN FNVYKATRPY LAHCPDCGEG
360 370 380 390 400
HSCHSPVALE RIRNEATDGT LKIQVSLQIG IKTDDSHDWT KLRYMDNHMP
410 420 430 440 450
ADAERAGLFV RTSAPCTITG TMGHFILARC PKGETLTVGF TDSRKISHSC
460 470 480 490 500
THPFHHDPPV IGREKFHSRP QHGKELPCST YVQSTAATTE EIEVHMPPDT
510 520 530 540 550
PDRTLMSQQS GNVKITVNGQ TVRYKCNCGG SNEGLTTTDK VINNCKVDQC
560 570 580 590 600
HAAVTNHKKW QYNSPLVPRN AELGDRKGKI HIPFPLANVT CRVPKARNPT
610 620 630 640 650
VTYGKNQVIM LLYPDHPTLL SYRNMGEEPN YQEEWVMHKK EVVLTVPTEG
660 670 680 690 700
LEVTWGNNEP YKYWPQLSTN GTAHGHPHEI ILYYYELYPT MTVVVVSVAT
710 720 730 740 750
FILLSMVGMA AGMCMCARRR CITPYELTPG ATVPFLLSLI CCIRTAKAAT
760 770 780 790 800
YQEAAIYLWN EQQPLFWLQA LIPLAALIVL CNCLRLLPCC CKTLAFLAVM
810 820 830 840 850
SVGAHTVSAY EHVTVIPNTV GVPYKTLVNR PGYSPMVLEM ELLSVTLEPT
860 870 880 890 900
LSLDYITCEY KTVIPSPYVK CCGTAECKDK NLPDYSCKVF TGVYPFMWGG
910 920 930 940 950
AYCFCDAENT QLSEAHVEKS ESCKTEFASA YRAHTASASA KLRVLYQGNN
960 970 980 990 1000
ITVTAYANGD HAVTVKDAKF IVGPMSSAWT PFDNKIVVYK GDVYNMDYPP
1010 1020 1030 1040 1050
FGAGRPGQFG DIQSRTPESK DVYANTQLVL QRPAAGTVHV PYSQAPSGFK
1060 1070 1080 1090 1100
YWLKERGASL QHTAPFGCQI ATNPVRAVNC AVGNMPISID IPEAAFTRVV
1110 1120 1130 1140 1150
DAPSLTDMSC EVPACTHSSD FGGVAIIKYA ASKKGKCAVH SMTNAVTIRE
1160 1170 1180 1190 1200
AEIEVEGNSQ LQISFSTALA SAEFRVQVCS TQVHCAAECH PPKDHIVNYP
1210 1220 1230 1240
ASHTTLGVQD ISATAMSWVQ KITGGVGLVV AVAALILIVV LCVSFSRH
Length:1,248
Mass (Da):138,310
Last modified:June 27, 2006 - v1
Checksum:i5CCEA5A7D8F2CB19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KF283986 Genomic RNA. Translation: AGX45492.1.
KF283987 Genomic RNA. Translation: AGX45493.1.
AM258990 Genomic RNA. Translation: CAJ90470.1.
AM258995 Genomic RNA. Translation: CAJ90481.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KF283986 Genomic RNA. Translation: AGX45492.1 .
KF283987 Genomic RNA. Translation: AGX45493.1 .
AM258990 Genomic RNA. Translation: CAJ90470.1 .
AM258995 Genomic RNA. Translation: CAJ90481.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XFB electron microscopy 9.00 A/D/F/H 810-1200 [» ]
B/E/G/I 333-666 [» ]
2XFC electron microscopy 9.00 A/D/F/H 810-1248 [» ]
B/E/G/I 326-748 [» ]
3J2W electron microscopy 5.00 A/B/C/D 810-1202 [» ]
3N40 X-ray 2.17 F 810-1200 [» ]
P 266-666 [» ]
3N41 X-ray 3.01 A 262-320 [» ]
B 326-667 [» ]
F 810-1190 [» ]
3N42 X-ray 3.00 A 262-319 [» ]
B 326-667 [» ]
F 810-1202 [» ]
3N43 X-ray 2.58 A 262-318 [» ]
B 326-667 [» ]
F 810-1200 [» ]
3N44 X-ray 2.35 A 262-325 [» ]
B 326-685 [» ]
F 810-1221 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59506N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q1H8W5.

Family and domain databases

Gene3Di 2.60.40.350. 1 hit.
2.60.98.10. 3 hits.
InterProi IPR002548. Alpha_E1_glycop.
IPR000936. Alpha_E2_glycop.
IPR002533. Alpha_E3_glycop.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014756. Ig_E-set.
IPR000930. Peptidase_S3.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01589. Alpha_E1_glycop. 1 hit.
PF00943. Alpha_E2_glycop. 1 hit.
PF01563. Alpha_E3_glycop. 1 hit.
PF00944. Peptidase_S3. 1 hit.
[Graphical view ]
PRINTSi PR00798. TOGAVIRIN.
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 05-115Imported.
  2. "Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak."
    Schuffenecker I., Iteman I., Michault A., Murri S., Frangeul L., Vaney M.C., Lavenir R., Pardigon N., Reynes J.M., Diancourt L., Michel S., Duquerroy S., Guigon G., Frenkiel M.P., Brehin A.C., Cubito N., Despres P., Kunst F.
    , Rey F.A., Zeller H., Brisse S.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 05-061Imported.
  3. "Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography."
    Voss J.E., Vaney M.C., Duquerroy S., Vonrhein C., Girard-Blanc C., Crublet E., Thompson A., Bricogne G., Rey F.A.
    Nature 468:709-712(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 810-1200 AND 266-666, GLYCOSYLATION AT ASN-273; ASN-588 AND ASN-950.
  4. "Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization."
    Sun S., Xiang Y., Akahata W., Holdaway H., Pal P., Zhang X., Diamond M.S., Nabel G.J., Rossmann M.G.
    Elife 2:e00435-e00435(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.00 ANGSTROMS) OF 810-1202.
  5. "Chikungunya virus variants identified in human serum isolate from Comoros Island, 2005."
    Wasonga C.O., Michuki G.N., Rumberia C.N., Musila L.A., Kimotho J.H., Ongus J.R., Inoue S., Sang R.C.
    Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: L2Imported and S7Imported.

Entry informationi

Entry nameiQ1H8W5_CHIKV
AccessioniPrimary (citable) accession number: Q1H8W5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3