SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1H8W5

- Q1H8W5_CHIKV

UniProt

Q1H8W5 - Q1H8W5_CHIKV

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Structural polyprotein

Gene
N/A
Organism
Chikungunya virus (CHIKV)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseSAAS annotations

Keywords - Biological processi

Fusion of virus membrane with host endosomal membraneSAAS annotations, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
Structural polyproteinImported
OrganismiChikungunya virus (CHIKV)Imported
Taxonomic identifieri37124 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTogaviridaeAlphavirusSFV complex
Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) [TaxID: 7160]
Aedes furcifer (Mosquito) [TaxID: 299627]
Aedes polynesiensis (Polynesian tiger mosquito) [TaxID: 188700]
Cercopithecus [TaxID: 9533]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Pan troglodytes (Chimpanzee) [TaxID: 9598]
Papio (baboons) [TaxID: 9554]
Presbytis [TaxID: 9573]

Subcellular locationi

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral capsid Source: UniProtKB-KW
  4. virion membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotations, Host membraneSAAS annotations, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261capsidImportedPRO_5000079763Add
BLAST
Chaini262 – 32564glycoprotein E3ImportedPRO_5000079764Add
BLAST
Chaini326 – 748423glycoprotein E2ImportedPRO_5000079765Add
BLAST
Chaini749 – 80961glycoprotein 6KImportedPRO_5000079766Add
BLAST
Chaini810 – 1248439glycoprotein E1ImportedPRO_5000079767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi273 – 2731N-linked (GlcNAc...)
Glycosylationi588 – 5881N-linked (GlcNAc...)Imported
Glycosylationi950 – 9501N-linked (GlcNAc...)Imported

Keywords - PTMi

Disulfide bondSAAS annotations

Interactioni

Protein-protein interaction databases

DIPiDIP-59506N.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XFBelectron microscopy9.00A/D/F/H810-1200[»]
B/E/G/I333-666[»]
2XFCelectron microscopy9.00A/D/F/H810-1248[»]
B/E/G/I326-748[»]
3J2Welectron microscopy5.00A/B/C/D810-1202[»]
3N40X-ray2.17F810-1200[»]
P266-666[»]
3N41X-ray3.01A262-320[»]
B326-667[»]
F810-1190[»]
3N42X-ray3.00A262-319[»]
B326-667[»]
F810-1202[»]
3N43X-ray2.58A262-318[»]
B326-667[»]
F810-1200[»]
3N44X-ray2.35A262-325[»]
B326-685[»]
F810-1221[»]

Miscellaneous databases

EvolutionaryTraceiQ1H8W5.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 3 hits.
InterProiIPR002548. Alpha_E1_glycop.
IPR000936. Alpha_E2_glycop.
IPR002533. Alpha_E3_glycop.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014756. Ig_E-set.
IPR000930. Peptidase_S3.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01589. Alpha_E1_glycop. 1 hit.
PF00943. Alpha_E2_glycop. 1 hit.
PF01563. Alpha_E3_glycop. 1 hit.
PF00944. Peptidase_S3. 1 hit.
[Graphical view]
PRINTSiPR00798. TOGAVIRIN.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1H8W5-1 [UniParc]FASTAAdd to Basket

« Hide

MEFIPTQTFY NRRYQPRPWT PRPTIQVIRP RPRPQRQAGQ LAQLISAVNK     50
LTMRAVPQQK PRRNRKNKKQ KQKQQAPQNN TNQKKQPPKK KPAQKKKKPG 100
RRERMCMKIE NDCIFEVKHE GKVTGYACLV GDKVMKPAHV KGTIDNADLA 150
KLAFKRSSKY DLECAQIPVH MKSDASKFTH EKPEGYYNWH HGAVQYSGGR 200
FTIPTGAGKP GDSGRPIFDN KGRVVAIVLG GANEGARTAL SVVTWNKDIV 250
TKITPEGAEE WSLAIPVMCL LANTTFPCSQ PPCTPCCYEK EPEETLRMLE 300
DNVMRPGYYQ LLQASLTCSP HRQRRSTKDN FNVYKATRPY LAHCPDCGEG 350
HSCHSPVALE RIRNEATDGT LKIQVSLQIG IKTDDSHDWT KLRYMDNHMP 400
ADAERAGLFV RTSAPCTITG TMGHFILARC PKGETLTVGF TDSRKISHSC 450
THPFHHDPPV IGREKFHSRP QHGKELPCST YVQSTAATTE EIEVHMPPDT 500
PDRTLMSQQS GNVKITVNGQ TVRYKCNCGG SNEGLTTTDK VINNCKVDQC 550
HAAVTNHKKW QYNSPLVPRN AELGDRKGKI HIPFPLANVT CRVPKARNPT 600
VTYGKNQVIM LLYPDHPTLL SYRNMGEEPN YQEEWVMHKK EVVLTVPTEG 650
LEVTWGNNEP YKYWPQLSTN GTAHGHPHEI ILYYYELYPT MTVVVVSVAT 700
FILLSMVGMA AGMCMCARRR CITPYELTPG ATVPFLLSLI CCIRTAKAAT 750
YQEAAIYLWN EQQPLFWLQA LIPLAALIVL CNCLRLLPCC CKTLAFLAVM 800
SVGAHTVSAY EHVTVIPNTV GVPYKTLVNR PGYSPMVLEM ELLSVTLEPT 850
LSLDYITCEY KTVIPSPYVK CCGTAECKDK NLPDYSCKVF TGVYPFMWGG 900
AYCFCDAENT QLSEAHVEKS ESCKTEFASA YRAHTASASA KLRVLYQGNN 950
ITVTAYANGD HAVTVKDAKF IVGPMSSAWT PFDNKIVVYK GDVYNMDYPP 1000
FGAGRPGQFG DIQSRTPESK DVYANTQLVL QRPAAGTVHV PYSQAPSGFK 1050
YWLKERGASL QHTAPFGCQI ATNPVRAVNC AVGNMPISID IPEAAFTRVV 1100
DAPSLTDMSC EVPACTHSSD FGGVAIIKYA ASKKGKCAVH SMTNAVTIRE 1150
AEIEVEGNSQ LQISFSTALA SAEFRVQVCS TQVHCAAECH PPKDHIVNYP 1200
ASHTTLGVQD ISATAMSWVQ KITGGVGLVV AVAALILIVV LCVSFSRH 1248
Length:1,248
Mass (Da):138,310
Last modified:June 27, 2006 - v1
Checksum:i5CCEA5A7D8F2CB19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KF283986 Genomic RNA. Translation: AGX45492.1.
KF283987 Genomic RNA. Translation: AGX45493.1.
AM258990 Genomic RNA. Translation: CAJ90470.1.
AM258995 Genomic RNA. Translation: CAJ90481.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KF283986 Genomic RNA. Translation: AGX45492.1 .
KF283987 Genomic RNA. Translation: AGX45493.1 .
AM258990 Genomic RNA. Translation: CAJ90470.1 .
AM258995 Genomic RNA. Translation: CAJ90481.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XFB electron microscopy 9.00 A/D/F/H 810-1200 [» ]
B/E/G/I 333-666 [» ]
2XFC electron microscopy 9.00 A/D/F/H 810-1248 [» ]
B/E/G/I 326-748 [» ]
3J2W electron microscopy 5.00 A/B/C/D 810-1202 [» ]
3N40 X-ray 2.17 F 810-1200 [» ]
P 266-666 [» ]
3N41 X-ray 3.01 A 262-320 [» ]
B 326-667 [» ]
F 810-1190 [» ]
3N42 X-ray 3.00 A 262-319 [» ]
B 326-667 [» ]
F 810-1202 [» ]
3N43 X-ray 2.58 A 262-318 [» ]
B 326-667 [» ]
F 810-1200 [» ]
3N44 X-ray 2.35 A 262-325 [» ]
B 326-685 [» ]
F 810-1221 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59506N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q1H8W5.

Family and domain databases

Gene3Di 2.60.40.350. 1 hit.
2.60.98.10. 3 hits.
InterProi IPR002548. Alpha_E1_glycop.
IPR000936. Alpha_E2_glycop.
IPR002533. Alpha_E3_glycop.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014756. Ig_E-set.
IPR000930. Peptidase_S3.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01589. Alpha_E1_glycop. 1 hit.
PF00943. Alpha_E2_glycop. 1 hit.
PF01563. Alpha_E3_glycop. 1 hit.
PF00944. Peptidase_S3. 1 hit.
[Graphical view ]
PRINTSi PR00798. TOGAVIRIN.
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 05-115Imported.
  2. "Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak."
    Schuffenecker I., Iteman I., Michault A., Murri S., Frangeul L., Vaney M.C., Lavenir R., Pardigon N., Reynes J.M., Diancourt L., Michel S., Duquerroy S., Guigon G., Frenkiel M.P., Brehin A.C., Cubito N., Despres P., Kunst F.
    , Rey F.A., Zeller H., Brisse S.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 05-061Imported.
  3. "Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography."
    Voss J.E., Vaney M.C., Duquerroy S., Vonrhein C., Girard-Blanc C., Crublet E., Thompson A., Bricogne G., Rey F.A.
    Nature 468:709-712(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 810-1200 AND 266-666, GLYCOSYLATION AT ASN-273; ASN-588 AND ASN-950.
  4. "Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization."
    Sun S., Xiang Y., Akahata W., Holdaway H., Pal P., Zhang X., Diamond M.S., Nabel G.J., Rossmann M.G.
    Elife 2:e00435-e00435(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.00 ANGSTROMS) OF 810-1202.
  5. "Chikungunya virus variants identified in human serum isolate from Comoros Island, 2005."
    Wasonga C.O., Michuki G.N., Rumberia C.N., Musila L.A., Kimotho J.H., Ongus J.R., Inoue S., Sang R.C.
    Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: L2Imported and S7Imported.

Entry informationi

Entry nameiQ1H8W5_CHIKV
AccessioniPrimary (citable) accession number: Q1H8W5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

Similar proteinsi