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Protein
Submitted name:

Structural polyprotein

Gene
N/A
Organism
Chikungunya virus (CHIKV)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseSAAS annotation

Keywords - Biological processi

Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
Structural polyproteinImported
OrganismiChikungunya virus (CHIKV)Imported
Taxonomic identifieri37124 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTogaviridaeAlphavirusSFV complex
Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) [TaxID: 7160]
Aedes furcifer (Mosquito) [TaxID: 299627]
Aedes polynesiensis (Polynesian tiger mosquito) [TaxID: 188700]
Cercopithecus [TaxID: 9533]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Pan troglodytes (Chimpanzee) [TaxID: 9598]
Papio (baboons) [TaxID: 9554]
Presbytis [TaxID: 9573]

Subcellular locationi

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral capsid Source: UniProtKB-KW
  4. virion membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261capsidImportedPRO_5000079763Add
BLAST
Chaini262 – 32564glycoprotein E3ImportedPRO_5000079764Add
BLAST
Chaini326 – 748423glycoprotein E2ImportedPRO_5000079765Add
BLAST
Chaini749 – 80961glycoprotein 6KImportedPRO_5000079766Add
BLAST
Chaini810 – 1248439glycoprotein E1ImportedPRO_5000079767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi269 ↔ 278Combined sources
Glycosylationi273 – 2731N-linked (GlcNAc...)Combined sources
Disulfide bondi283 ↔ 287Combined sources
Disulfide bondi286 ↔ 318Combined sources
Disulfide bondi344 ↔ 450Combined sources
Disulfide bondi347 ↔ 353Combined sources
Disulfide bondi416 ↔ 430Combined sources
Disulfide bondi478 ↔ 591Combined sources
Disulfide bondi526 ↔ 550Combined sources
Disulfide bondi528 ↔ 545Combined sources
Glycosylationi588 – 5881N-linked (GlcNAc...)Combined sources
Disulfide bondi858 ↔ 923Combined sources
Disulfide bondi871 ↔ 903Combined sources
Disulfide bondi872 ↔ 905Combined sources
Disulfide bondi877 ↔ 887Combined sources
Glycosylationi950 – 9501N-linked (GlcNAc...)Combined sources
Disulfide bondi1068 ↔ 1080Combined sources
Disulfide bondi1110 ↔ 1185Combined sources
Disulfide bondi1115 ↔ 1189Combined sources
Disulfide bondi1137 ↔ 1179Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

DIPiDIP-59506N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XFBelectron microscopy9.00A/D/F/H810-1200[»]
B/E/G/I333-666[»]
2XFCelectron microscopy9.00A/D/F/H810-1248[»]
B/E/G/I326-748[»]
3J2Welectron microscopy5.00A/B/C/D810-1202[»]
3N40X-ray2.17F810-1200[»]
P266-666[»]
3N41X-ray3.01A262-320[»]
B326-667[»]
F810-1190[»]
3N42X-ray3.00A262-319[»]
B326-667[»]
F810-1202[»]
3N43X-ray2.58A262-318[»]
B326-667[»]
F810-1200[»]
3N44X-ray2.35A262-325[»]
B326-685[»]
F810-1221[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ1H8W5.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 3 hits.
InterProiIPR002548. Alpha_E1_glycop.
IPR000936. Alpha_E2_glycop.
IPR002533. Alpha_E3_glycop.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014756. Ig_E-set.
IPR000930. Peptidase_S3.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01589. Alpha_E1_glycop. 1 hit.
PF00943. Alpha_E2_glycop. 1 hit.
PF01563. Alpha_E3_glycop. 1 hit.
PF00944. Peptidase_S3. 1 hit.
[Graphical view]
PRINTSiPR00798. TOGAVIRIN.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS51690. ALPHAVIRUS_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1H8W5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFIPTQTFY NRRYQPRPWT PRPTIQVIRP RPRPQRQAGQ LAQLISAVNK
60 70 80 90 100
LTMRAVPQQK PRRNRKNKKQ KQKQQAPQNN TNQKKQPPKK KPAQKKKKPG
110 120 130 140 150
RRERMCMKIE NDCIFEVKHE GKVTGYACLV GDKVMKPAHV KGTIDNADLA
160 170 180 190 200
KLAFKRSSKY DLECAQIPVH MKSDASKFTH EKPEGYYNWH HGAVQYSGGR
210 220 230 240 250
FTIPTGAGKP GDSGRPIFDN KGRVVAIVLG GANEGARTAL SVVTWNKDIV
260 270 280 290 300
TKITPEGAEE WSLAIPVMCL LANTTFPCSQ PPCTPCCYEK EPEETLRMLE
310 320 330 340 350
DNVMRPGYYQ LLQASLTCSP HRQRRSTKDN FNVYKATRPY LAHCPDCGEG
360 370 380 390 400
HSCHSPVALE RIRNEATDGT LKIQVSLQIG IKTDDSHDWT KLRYMDNHMP
410 420 430 440 450
ADAERAGLFV RTSAPCTITG TMGHFILARC PKGETLTVGF TDSRKISHSC
460 470 480 490 500
THPFHHDPPV IGREKFHSRP QHGKELPCST YVQSTAATTE EIEVHMPPDT
510 520 530 540 550
PDRTLMSQQS GNVKITVNGQ TVRYKCNCGG SNEGLTTTDK VINNCKVDQC
560 570 580 590 600
HAAVTNHKKW QYNSPLVPRN AELGDRKGKI HIPFPLANVT CRVPKARNPT
610 620 630 640 650
VTYGKNQVIM LLYPDHPTLL SYRNMGEEPN YQEEWVMHKK EVVLTVPTEG
660 670 680 690 700
LEVTWGNNEP YKYWPQLSTN GTAHGHPHEI ILYYYELYPT MTVVVVSVAT
710 720 730 740 750
FILLSMVGMA AGMCMCARRR CITPYELTPG ATVPFLLSLI CCIRTAKAAT
760 770 780 790 800
YQEAAIYLWN EQQPLFWLQA LIPLAALIVL CNCLRLLPCC CKTLAFLAVM
810 820 830 840 850
SVGAHTVSAY EHVTVIPNTV GVPYKTLVNR PGYSPMVLEM ELLSVTLEPT
860 870 880 890 900
LSLDYITCEY KTVIPSPYVK CCGTAECKDK NLPDYSCKVF TGVYPFMWGG
910 920 930 940 950
AYCFCDAENT QLSEAHVEKS ESCKTEFASA YRAHTASASA KLRVLYQGNN
960 970 980 990 1000
ITVTAYANGD HAVTVKDAKF IVGPMSSAWT PFDNKIVVYK GDVYNMDYPP
1010 1020 1030 1040 1050
FGAGRPGQFG DIQSRTPESK DVYANTQLVL QRPAAGTVHV PYSQAPSGFK
1060 1070 1080 1090 1100
YWLKERGASL QHTAPFGCQI ATNPVRAVNC AVGNMPISID IPEAAFTRVV
1110 1120 1130 1140 1150
DAPSLTDMSC EVPACTHSSD FGGVAIIKYA ASKKGKCAVH SMTNAVTIRE
1160 1170 1180 1190 1200
AEIEVEGNSQ LQISFSTALA SAEFRVQVCS TQVHCAAECH PPKDHIVNYP
1210 1220 1230 1240
ASHTTLGVQD ISATAMSWVQ KITGGVGLVV AVAALILIVV LCVSFSRH
Length:1,248
Mass (Da):138,310
Last modified:June 27, 2006 - v1
Checksum:i5CCEA5A7D8F2CB19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF283986 Genomic RNA. Translation: AGX45492.1.
KF283987 Genomic RNA. Translation: AGX45493.1.
AM258990 Genomic RNA. Translation: CAJ90470.1.
AM258995 Genomic RNA. Translation: CAJ90481.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF283986 Genomic RNA. Translation: AGX45492.1.
KF283987 Genomic RNA. Translation: AGX45493.1.
AM258990 Genomic RNA. Translation: CAJ90470.1.
AM258995 Genomic RNA. Translation: CAJ90481.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XFBelectron microscopy9.00A/D/F/H810-1200[»]
B/E/G/I333-666[»]
2XFCelectron microscopy9.00A/D/F/H810-1248[»]
B/E/G/I326-748[»]
3J2Welectron microscopy5.00A/B/C/D810-1202[»]
3N40X-ray2.17F810-1200[»]
P266-666[»]
3N41X-ray3.01A262-320[»]
B326-667[»]
F810-1190[»]
3N42X-ray3.00A262-319[»]
B326-667[»]
F810-1202[»]
3N43X-ray2.58A262-318[»]
B326-667[»]
F810-1200[»]
3N44X-ray2.35A262-325[»]
B326-685[»]
F810-1221[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59506N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ1H8W5.

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 3 hits.
InterProiIPR002548. Alpha_E1_glycop.
IPR000936. Alpha_E2_glycop.
IPR002533. Alpha_E3_glycop.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014756. Ig_E-set.
IPR000930. Peptidase_S3.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01589. Alpha_E1_glycop. 1 hit.
PF00943. Alpha_E2_glycop. 1 hit.
PF01563. Alpha_E3_glycop. 1 hit.
PF00944. Peptidase_S3. 1 hit.
[Graphical view]
PRINTSiPR00798. TOGAVIRIN.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS51690. ALPHAVIRUS_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 05-115Imported.
  2. "Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak."
    Schuffenecker I., Iteman I., Michault A., Murri S., Frangeul L., Vaney M.C., Lavenir R., Pardigon N., Reynes J.M., Diancourt L., Michel S., Duquerroy S., Guigon G., Frenkiel M.P., Brehin A.C., Cubito N., Despres P., Kunst F.
    , Rey F.A., Zeller H., Brisse S.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 05-061Imported.
  3. "Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography."
    Voss J.E., Vaney M.C., Duquerroy S., Vonrhein C., Girard-Blanc C., Crublet E., Thompson A., Bricogne G., Rey F.A.
    Nature 468:709-712(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 810-1200 AND 266-666, ACTIVE SITE, GLYCOSYLATION AT ASN-273; ASN-588 AND ASN-950.
  4. "Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization."
    Sun S., Xiang Y., Akahata W., Holdaway H., Pal P., Zhang X., Diamond M.S., Nabel G.J., Rossmann M.G.
    Elife 2:e00435-e00435(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.00 ANGSTROMS) OF 810-1202, ACTIVE SITE.
  5. "Chikungunya virus variants identified in human serum isolate from Comoros Island, 2005."
    Wasonga C.O., Michuki G.N., Rumberia C.N., Musila L.A., Kimotho J.H., Ongus J.R., Inoue S., Sang R.C.
    Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: L2Imported and S7Imported.

Entry informationi

Entry nameiQ1H8W5_CHIKV
AccessioniPrimary (citable) accession number: Q1H8W5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: February 4, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.