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Q1H8W5

- Q1H8W5_CHIKV

UniProt

Q1H8W5 - Q1H8W5_CHIKV

Protein
Submitted name:

Structural polyprotein

Gene
N/A
Organism
Chikungunya virus (CHIKV)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseSAAS annotation

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Structural polyproteinImported
    OrganismiChikungunya virus (CHIKV)Imported
    Taxonomic identifieri37124 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTogaviridaeAlphavirusSFV complex
    Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
    Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) [TaxID: 7160]
    Aedes furcifer (Mosquito) [TaxID: 299627]
    Aedes polynesiensis (Polynesian tiger mosquito) [TaxID: 188700]
    Cercopithecus [TaxID: 9533]
    Homo sapiens (Human) [TaxID: 9606]
    Macaca (macaques) [TaxID: 9539]
    Pan troglodytes (Chimpanzee) [TaxID: 9598]
    Papio (baboons) [TaxID: 9554]
    Presbytis [TaxID: 9573]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell membrane Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. viral capsid Source: UniProtKB-KW
    4. virion membrane Source: InterPro

    Keywords - Cellular componenti

    Capsid proteinSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261capsidImportedPRO_5000079763Add
    BLAST
    Chaini262 – 32564glycoprotein E3ImportedPRO_5000079764Add
    BLAST
    Chaini326 – 748423glycoprotein E2ImportedPRO_5000079765Add
    BLAST
    Chaini749 – 80961glycoprotein 6KImportedPRO_5000079766Add
    BLAST
    Chaini810 – 1248439glycoprotein E1ImportedPRO_5000079767Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi273 – 2731N-linked (GlcNAc...)
    Glycosylationi588 – 5881N-linked (GlcNAc...)Imported
    Glycosylationi950 – 9501N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-59506N.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XFBelectron microscopy9.00A/D/F/H810-1200[»]
    B/E/G/I333-666[»]
    2XFCelectron microscopy9.00A/D/F/H810-1248[»]
    B/E/G/I326-748[»]
    3J2Welectron microscopy5.00A/B/C/D810-1202[»]
    3N40X-ray2.17F810-1200[»]
    P266-666[»]
    3N41X-ray3.01A262-320[»]
    B326-667[»]
    F810-1190[»]
    3N42X-ray3.00A262-319[»]
    B326-667[»]
    F810-1202[»]
    3N43X-ray2.58A262-318[»]
    B326-667[»]
    F810-1200[»]
    3N44X-ray2.35A262-325[»]
    B326-685[»]
    F810-1221[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ1H8W5.

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.60.40.350. 1 hit.
    2.60.98.10. 3 hits.
    InterProiIPR002548. Alpha_E1_glycop.
    IPR000936. Alpha_E2_glycop.
    IPR002533. Alpha_E3_glycop.
    IPR000336. Flavivir/Alphavir_Ig-like.
    IPR011998. Glycoprot_cen/dimer.
    IPR013754. GlyE_dim.
    IPR014756. Ig_E-set.
    IPR000930. Peptidase_S3.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF01589. Alpha_E1_glycop. 1 hit.
    PF00943. Alpha_E2_glycop. 1 hit.
    PF01563. Alpha_E3_glycop. 1 hit.
    PF00944. Peptidase_S3. 1 hit.
    [Graphical view]
    PRINTSiPR00798. TOGAVIRIN.
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF56983. SSF56983. 1 hit.
    SSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1H8W5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFIPTQTFY NRRYQPRPWT PRPTIQVIRP RPRPQRQAGQ LAQLISAVNK     50
    LTMRAVPQQK PRRNRKNKKQ KQKQQAPQNN TNQKKQPPKK KPAQKKKKPG 100
    RRERMCMKIE NDCIFEVKHE GKVTGYACLV GDKVMKPAHV KGTIDNADLA 150
    KLAFKRSSKY DLECAQIPVH MKSDASKFTH EKPEGYYNWH HGAVQYSGGR 200
    FTIPTGAGKP GDSGRPIFDN KGRVVAIVLG GANEGARTAL SVVTWNKDIV 250
    TKITPEGAEE WSLAIPVMCL LANTTFPCSQ PPCTPCCYEK EPEETLRMLE 300
    DNVMRPGYYQ LLQASLTCSP HRQRRSTKDN FNVYKATRPY LAHCPDCGEG 350
    HSCHSPVALE RIRNEATDGT LKIQVSLQIG IKTDDSHDWT KLRYMDNHMP 400
    ADAERAGLFV RTSAPCTITG TMGHFILARC PKGETLTVGF TDSRKISHSC 450
    THPFHHDPPV IGREKFHSRP QHGKELPCST YVQSTAATTE EIEVHMPPDT 500
    PDRTLMSQQS GNVKITVNGQ TVRYKCNCGG SNEGLTTTDK VINNCKVDQC 550
    HAAVTNHKKW QYNSPLVPRN AELGDRKGKI HIPFPLANVT CRVPKARNPT 600
    VTYGKNQVIM LLYPDHPTLL SYRNMGEEPN YQEEWVMHKK EVVLTVPTEG 650
    LEVTWGNNEP YKYWPQLSTN GTAHGHPHEI ILYYYELYPT MTVVVVSVAT 700
    FILLSMVGMA AGMCMCARRR CITPYELTPG ATVPFLLSLI CCIRTAKAAT 750
    YQEAAIYLWN EQQPLFWLQA LIPLAALIVL CNCLRLLPCC CKTLAFLAVM 800
    SVGAHTVSAY EHVTVIPNTV GVPYKTLVNR PGYSPMVLEM ELLSVTLEPT 850
    LSLDYITCEY KTVIPSPYVK CCGTAECKDK NLPDYSCKVF TGVYPFMWGG 900
    AYCFCDAENT QLSEAHVEKS ESCKTEFASA YRAHTASASA KLRVLYQGNN 950
    ITVTAYANGD HAVTVKDAKF IVGPMSSAWT PFDNKIVVYK GDVYNMDYPP 1000
    FGAGRPGQFG DIQSRTPESK DVYANTQLVL QRPAAGTVHV PYSQAPSGFK 1050
    YWLKERGASL QHTAPFGCQI ATNPVRAVNC AVGNMPISID IPEAAFTRVV 1100
    DAPSLTDMSC EVPACTHSSD FGGVAIIKYA ASKKGKCAVH SMTNAVTIRE 1150
    AEIEVEGNSQ LQISFSTALA SAEFRVQVCS TQVHCAAECH PPKDHIVNYP 1200
    ASHTTLGVQD ISATAMSWVQ KITGGVGLVV AVAALILIVV LCVSFSRH 1248
    Length:1,248
    Mass (Da):138,310
    Last modified:June 27, 2006 - v1
    Checksum:i5CCEA5A7D8F2CB19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    KF283986 Genomic RNA. Translation: AGX45492.1.
    KF283987 Genomic RNA. Translation: AGX45493.1.
    AM258990 Genomic RNA. Translation: CAJ90470.1.
    AM258995 Genomic RNA. Translation: CAJ90481.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    KF283986 Genomic RNA. Translation: AGX45492.1 .
    KF283987 Genomic RNA. Translation: AGX45493.1 .
    AM258990 Genomic RNA. Translation: CAJ90470.1 .
    AM258995 Genomic RNA. Translation: CAJ90481.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XFB electron microscopy 9.00 A/D/F/H 810-1200 [» ]
    B/E/G/I 333-666 [» ]
    2XFC electron microscopy 9.00 A/D/F/H 810-1248 [» ]
    B/E/G/I 326-748 [» ]
    3J2W electron microscopy 5.00 A/B/C/D 810-1202 [» ]
    3N40 X-ray 2.17 F 810-1200 [» ]
    P 266-666 [» ]
    3N41 X-ray 3.01 A 262-320 [» ]
    B 326-667 [» ]
    F 810-1190 [» ]
    3N42 X-ray 3.00 A 262-319 [» ]
    B 326-667 [» ]
    F 810-1202 [» ]
    3N43 X-ray 2.58 A 262-318 [» ]
    B 326-667 [» ]
    F 810-1200 [» ]
    3N44 X-ray 2.35 A 262-325 [» ]
    B 326-685 [» ]
    F 810-1221 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59506N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q1H8W5.

    Family and domain databases

    Gene3Di 2.60.40.350. 1 hit.
    2.60.98.10. 3 hits.
    InterProi IPR002548. Alpha_E1_glycop.
    IPR000936. Alpha_E2_glycop.
    IPR002533. Alpha_E3_glycop.
    IPR000336. Flavivir/Alphavir_Ig-like.
    IPR011998. Glycoprot_cen/dimer.
    IPR013754. GlyE_dim.
    IPR014756. Ig_E-set.
    IPR000930. Peptidase_S3.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF01589. Alpha_E1_glycop. 1 hit.
    PF00943. Alpha_E2_glycop. 1 hit.
    PF01563. Alpha_E3_glycop. 1 hit.
    PF00944. Peptidase_S3. 1 hit.
    [Graphical view ]
    PRINTSi PR00798. TOGAVIRIN.
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF56983. SSF56983. 1 hit.
    SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 05-115Imported.
    2. "Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak."
      Schuffenecker I., Iteman I., Michault A., Murri S., Frangeul L., Vaney M.C., Lavenir R., Pardigon N., Reynes J.M., Diancourt L., Michel S., Duquerroy S., Guigon G., Frenkiel M.P., Brehin A.C., Cubito N., Despres P., Kunst F.
      , Rey F.A., Zeller H., Brisse S.
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 05-061Imported.
    3. "Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography."
      Voss J.E., Vaney M.C., Duquerroy S., Vonrhein C., Girard-Blanc C., Crublet E., Thompson A., Bricogne G., Rey F.A.
      Nature 468:709-712(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 810-1200 AND 266-666, GLYCOSYLATION AT ASN-273; ASN-588 AND ASN-950.
    4. "Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization."
      Sun S., Xiang Y., Akahata W., Holdaway H., Pal P., Zhang X., Diamond M.S., Nabel G.J., Rossmann M.G.
      Elife 2:e00435-e00435(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.00 ANGSTROMS) OF 810-1202.
    5. "Chikungunya virus variants identified in human serum isolate from Comoros Island, 2005."
      Wasonga C.O., Michuki G.N., Rumberia C.N., Musila L.A., Kimotho J.H., Ongus J.R., Inoue S., Sang R.C.
      Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: L2Imported and S7Imported.

    Entry informationi

    Entry nameiQ1H8W5_CHIKV
    AccessioniPrimary (citable) accession number: Q1H8W5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3