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Q1H8W5 (Q1H8W5_CHIKV) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length1248 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261capsid EMBL CAJ90470.1
PRO_5000079763
Chain262 – 32564glycoprotein E3 EMBL CAJ90470.1
PRO_5000079764
Chain326 – 748423glycoprotein E2 EMBL CAJ90470.1
PRO_5000079765
Chain749 – 80961glycoprotein 6K EMBL CAJ90470.1
PRO_5000079766
Chain810 – 1248439glycoprotein E1 EMBL CAJ90470.1
PRO_5000079767

Regions

Region1028 – 10303Acetate 7 binding PDB 3N40 PDB 3N44

Sites

Binding site2931Acetate 1 PDB 3N44
Binding site3331Acetate 3; via amide nitrogen PDB 3N40
Binding site3891Acetate 4; via amide nitrogen PDB 3N40
Binding site4051Acetate 5 PDB 3N40
Binding site4211Acetate 5 PDB 3N40
Binding site10301Acetate 6; via amide nitrogen PDB 3N43

Amino acid modifications

Glycosylation2731N-linked (GlcNAc...) PDB 3N40
Glycosylation5881N-linked (GlcNAc...) PDB 3N40 PDB 3N43 PDB 3N44 PDB 3N41 PDB 3N42
Glycosylation9501N-linked (GlcNAc...) PDB 3N40 PDB 3N43 PDB 3N44 PDB 3N41 PDB 3N42

Sequences

Sequence LengthMass (Da)Tools
Q1H8W5 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: 5CCEA5A7D8F2CB19

FASTA1,248138,310
        10         20         30         40         50         60 
MEFIPTQTFY NRRYQPRPWT PRPTIQVIRP RPRPQRQAGQ LAQLISAVNK LTMRAVPQQK 

        70         80         90        100        110        120 
PRRNRKNKKQ KQKQQAPQNN TNQKKQPPKK KPAQKKKKPG RRERMCMKIE NDCIFEVKHE 

       130        140        150        160        170        180 
GKVTGYACLV GDKVMKPAHV KGTIDNADLA KLAFKRSSKY DLECAQIPVH MKSDASKFTH 

       190        200        210        220        230        240 
EKPEGYYNWH HGAVQYSGGR FTIPTGAGKP GDSGRPIFDN KGRVVAIVLG GANEGARTAL 

       250        260        270        280        290        300 
SVVTWNKDIV TKITPEGAEE WSLAIPVMCL LANTTFPCSQ PPCTPCCYEK EPEETLRMLE 

       310        320        330        340        350        360 
DNVMRPGYYQ LLQASLTCSP HRQRRSTKDN FNVYKATRPY LAHCPDCGEG HSCHSPVALE 

       370        380        390        400        410        420 
RIRNEATDGT LKIQVSLQIG IKTDDSHDWT KLRYMDNHMP ADAERAGLFV RTSAPCTITG 

       430        440        450        460        470        480 
TMGHFILARC PKGETLTVGF TDSRKISHSC THPFHHDPPV IGREKFHSRP QHGKELPCST 

       490        500        510        520        530        540 
YVQSTAATTE EIEVHMPPDT PDRTLMSQQS GNVKITVNGQ TVRYKCNCGG SNEGLTTTDK 

       550        560        570        580        590        600 
VINNCKVDQC HAAVTNHKKW QYNSPLVPRN AELGDRKGKI HIPFPLANVT CRVPKARNPT 

       610        620        630        640        650        660 
VTYGKNQVIM LLYPDHPTLL SYRNMGEEPN YQEEWVMHKK EVVLTVPTEG LEVTWGNNEP 

       670        680        690        700        710        720 
YKYWPQLSTN GTAHGHPHEI ILYYYELYPT MTVVVVSVAT FILLSMVGMA AGMCMCARRR 

       730        740        750        760        770        780 
CITPYELTPG ATVPFLLSLI CCIRTAKAAT YQEAAIYLWN EQQPLFWLQA LIPLAALIVL 

       790        800        810        820        830        840 
CNCLRLLPCC CKTLAFLAVM SVGAHTVSAY EHVTVIPNTV GVPYKTLVNR PGYSPMVLEM 

       850        860        870        880        890        900 
ELLSVTLEPT LSLDYITCEY KTVIPSPYVK CCGTAECKDK NLPDYSCKVF TGVYPFMWGG 

       910        920        930        940        950        960 
AYCFCDAENT QLSEAHVEKS ESCKTEFASA YRAHTASASA KLRVLYQGNN ITVTAYANGD 

       970        980        990       1000       1010       1020 
HAVTVKDAKF IVGPMSSAWT PFDNKIVVYK GDVYNMDYPP FGAGRPGQFG DIQSRTPESK 

      1030       1040       1050       1060       1070       1080 
DVYANTQLVL QRPAAGTVHV PYSQAPSGFK YWLKERGASL QHTAPFGCQI ATNPVRAVNC 

      1090       1100       1110       1120       1130       1140 
AVGNMPISID IPEAAFTRVV DAPSLTDMSC EVPACTHSSD FGGVAIIKYA ASKKGKCAVH 

      1150       1160       1170       1180       1190       1200 
SMTNAVTIRE AEIEVEGNSQ LQISFSTALA SAEFRVQVCS TQVHCAAECH PPKDHIVNYP 

      1210       1220       1230       1240 
ASHTTLGVQD ISATAMSWVQ KITGGVGLVV AVAALILIVV LCVSFSRH 

« Hide

References

[1]"Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak."
Schuffenecker I., Iteman I., Michault A., Murri S., Frangeul L., Vaney M.-C., Lavenir R., Pardigon N., Reynes J.-M., Pettinelli F., Biscornet L., Diancourt L., Michel S., Duquerroy S., Guigon G., Frenkiel M.-P., Brehin A.-C., Cubito N. expand/collapse author list , Despres P., Kunst F., Rey F.R., Zeller H., Brisse S.
PLoS Med. 3:e263-e263(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 05-115 EMBL CAJ90470.1.
[2]"Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak."
Schuffenecker I., Iteman I., Michault A., Murri S., Frangeul L., Vaney M.C., Lavenir R., Pardigon N., Reynes J.M., Diancourt L., Michel S., Duquerroy S., Guigon G., Frenkiel M.P., Brehin A.C., Cubito N., Despres P., Kunst F. expand/collapse author list , Rey F.A., Zeller H., Brisse S.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 05-061 EMBL CAJ90481.1.
[3]"Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography."
Voss J.E., Vaney M.C., Duquerroy S., Vonrhein C., Girard-Blanc C., Crublet E., Thompson A., Bricogne G., Rey F.A.
Nature 468:709-712(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 810-1200 AND 266-666 IN COMPLEX WITH ACETATE, GLYCOSYLATION AT ASN-273; ASN-588 AND ASN-950.
[4]"Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization."
Sun S., Xiang Y., Akahata W., Holdaway H., Pal P., Zhang X., Diamond M.S., Nabel G.J., Rossmann M.G.
Elife 2:e00435-e00435(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.00 ANGSTROMS) OF 810-1202.
[5]"Chikungunya virus variants identified in human serum isolate from Comoros Island, 2005."
Wasonga C.O., Michuki G.N., Rumberia C.N., Musila L.A., Kimotho J.H., Ongus J.R., Inoue S., Sang R.C.
Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: L2 EMBL AGX45492.1 and S7 EMBL AGX45493.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
KF283986 Genomic RNA. Translation: AGX45492.1.
KF283987 Genomic RNA. Translation: AGX45493.1.
AM258990 Genomic RNA. Translation: CAJ90470.1.
AM258995 Genomic RNA. Translation: CAJ90481.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2XFBelectron microscopy9.00A/D/F/H810-1200[»]
B/E/G/I333-666[»]
2XFCelectron microscopy9.00A/D/F/H810-1248[»]
B/E/G/I326-748[»]
3J2Welectron microscopy5.00A/B/C/D810-1202[»]
3N40X-ray2.17F810-1200[»]
P266-666[»]
3N41X-ray3.01A262-320[»]
B326-667[»]
F810-1190[»]
3N42X-ray3.00A262-319[»]
B326-667[»]
F810-1202[»]
3N43X-ray2.58A262-318[»]
B326-667[»]
F810-1200[»]
3N44X-ray2.35A262-325[»]
B326-685[»]
F810-1221[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59506N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.350. 1 hit.
2.60.98.10. 3 hits.
InterProIPR002548. Alpha_E1_glycop.
IPR000936. Alpha_E2_glycop.
IPR002533. Alpha_E3_glycop.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014756. Ig_E-set.
IPR000930. Peptidase_S3.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF01589. Alpha_E1_glycop. 1 hit.
PF00943. Alpha_E2_glycop. 1 hit.
PF01563. Alpha_E3_glycop. 1 hit.
PF00944. Peptidase_S3. 1 hit.
[Graphical view]
PRINTSPR00798. TOGAVIRIN.
SUPFAMSSF50494. SSF50494. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ1H8W5.

Entry information

Entry nameQ1H8W5_CHIKV
AccessionPrimary (citable) accession number: Q1H8W5
Entry history
Integrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)