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Q1H4T5

- TRMB_METFK

UniProt

Q1H4T5 - TRMB_METFK

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei71 – 711S-adenosyl-L-methionineUniRule annotation
    Binding sitei96 – 961S-adenosyl-L-methionineUniRule annotation
    Binding sitei123 – 1231S-adenosyl-L-methionineUniRule annotation
    Active sitei146 – 1461By similarity
    Binding sitei146 – 1461S-adenosyl-L-methionineUniRule annotation
    Binding sitei150 – 1501SubstrateUniRule annotation
    Binding sitei182 – 1821SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMFLA265072:GHWJ-243-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Mfla_0231
    OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
    Taxonomic identifieri265072 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
    ProteomesiUP000002440: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238tRNA (guanine-N(7)-)-methyltransferasePRO_0000288179Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi265072.Mfla_0231.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1H4T5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni217 – 2204Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiRERANAK.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1H4T5-1 [UniParc]FASTAAdd to Basket

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    MAQEMTGNEN IGKEELARRP IRSFVLRQGR LTHAQQRALD ELMPVFGVPY    50
    APVILDLDSL FGREGSPKVL EIGFGMGDST AKIAQSQPEC DFIGVEVHTP 100
    GVGSLLKQIG ELQLNNLRII QHDAVEVLQH MIADASLDGV HIFFPDPWHK 150
    KRHHKRRLIQ AAFVKLLCSK MKAGAYLHVA TDWQEYAEWV LDILQQEPLL 200
    ENTAQSYAPK PDYRPLTKFE NRGIKLGHGV WDIIFRRK 238
    Length:238
    Mass (Da):27,021
    Last modified:June 27, 2006 - v1
    Checksum:iFCE94BFE65F533A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE48502.1.
    RefSeqiWP_011478599.1. NC_007947.1.
    YP_544343.1. NC_007947.1.

    Genome annotation databases

    EnsemblBacteriaiABE48502; ABE48502; Mfla_0231.
    GeneIDi3999360.
    KEGGimfa:Mfla_0231.
    PATRICi32265977. VBIMetFla97085_0236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE48502.1 .
    RefSeqi WP_011478599.1. NC_007947.1.
    YP_544343.1. NC_007947.1.

    3D structure databases

    ProteinModelPortali Q1H4T5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265072.Mfla_0231.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE48502 ; ABE48502 ; Mfla_0231 .
    GeneIDi 3999360.
    KEGGi mfa:Mfla_0231.
    PATRICi 32265977. VBIMetFla97085_0236.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi RERANAK.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MFLA265072:GHWJ-243-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT / ATCC 51484 / DSM 6875.

    Entry informationi

    Entry nameiTRMB_METFK
    AccessioniPrimary (citable) accession number: Q1H4T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3