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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transferase
Biological processPurine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Mfla_0349
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesMethylophilaceaeMethylobacillus
Proteomesi
  • UP000002440 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000764841 – 528Bifunctional purine biosynthesis protein PurHAdd BLAST528

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_0349.

Structurei

3D structure databases

ProteinModelPortaliQ1H4G7.
SMRiQ1H4G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DC1. Bacteria.
COG0138. LUCA.
HOGENOMiHOG000230372.
KOiK00602.
OMAiDLLFAWK.
OrthoDBiPOG091H00UT.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH. 1 hit.
InterProiView protein in InterPro
IPR024051. AICAR_Tfase_dup_dom_sf.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
IPR036914. MGS-like_dom_sf.
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiView protein in Pfam
PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiView protein in SMART
SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1H4G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVIKRALIS VSDKTGILEF AKALAEFGVE ILSTGGTAKL FRDNGIPVTE
60 70 80 90 100
VSDYTGFPEM LDGRVKTLHP KIHGGLLGRR DLPEHVTAMQ AAGIPDIDMI
110 120 130 140 150
VVNLYPFEAT VARPDATLED AIENIDIGGP AMVRSAAKNW QDVAVLTDAS
160 170 180 190 200
QYEEVLAEMR STGGATSKAT RFALSVAAFN RISNYDGAIS DYLSSFNADG
210 220 230 240 250
TRNEFPGQIN GRLVKVQDLR YGENPHQQAA FYRDLYPAPG SLVTAQQLQG
260 270 280 290 300
KELSYNNIAD ADAAWECVKS FDSTACVIVK HANPCGVALG ATPLEAYQKA
310 320 330 340 350
FQTDPTSAFG GIIAFNHTLD GAAAEAVSKQ FVEVLIAPDY TEEALAVFKA
360 370 380 390 400
KANVRVLKIA LPVGGDSPWS RGRNSHDTKR VGSGVLIQTA DNHEISAADI
410 420 430 440 450
KVVTKKQPTP EQLEDLLFAW RVAKYVKSNA IVFCGNGMTL GVGAGQMSRV
460 470 480 490 500
DSTRIAAIKA QNAGLSLQGS AVASDAFFPF RDGVDVLAEA GASCVIQPGG
510 520
SIRDDEVIAA ADEHGLVMIF TNIRHFRH
Length:528
Mass (Da):56,430
Last modified:June 27, 2006 - v1
Checksum:i5ED93D58E0752A67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE48620.1.
RefSeqiWP_011478717.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE48620; ABE48620; Mfla_0349.
KEGGimfa:Mfla_0349.

Similar proteinsi

Entry informationi

Entry nameiPUR9_METFK
AccessioniPrimary (citable) accession number: Q1H4G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 27, 2006
Last modified: November 22, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families