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Q1H397 (HEMH_METFK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Mfla_0772
OrganismMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) [Complete proteome] [HAMAP]
Taxonomic identifier265072 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Ferrochelatase HAMAP MF_00323
PRO_1000072024

Sites

Metal binding2111Iron By similarity
Metal binding2921Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1H397 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: 54CBEA2CA8C5AF4D

FASTA34439,207
        10         20         30         40         50         60 
MAYYLKEPSI PTQEPERTGI LVMNLGTPEA PTAKALRPYL RQFLSDRRVI ELPRPLWWFI 

        70         80         90        100        110        120 
LNGVILVLRP RQSAHKYATI WDKEGPPLMV NSQKQARLLE GYLHEAISSP YAVELGMRYG 

       130        140        150        160        170        180 
SPSIASALGK LKAKNCNRIL LFPLYPQYAA SSSASALDEA MRTLIRTRNM PEIRTIRDYH 

       190        200        210        220        230        240 
DHPAYIHAVA KSIRLYWQQH GKPEKLVMSF HGVPRRTYDL GDPYYDQCQT SGKLVAQALG 

       250        260        270        280        290        300 
LEEDQYMIAF QSRFGTAEWL QPYFAPSIQA LGKQKLRRVD VVCPGFSSDC LETLEEIAME 

       310        320        330        340 
GKSLFLEGGG GEYHYIPALN DNDTWIKAMR EIALDNLQGW VTRR

« Hide

References

[1]"Complete sequence of Methylobacillus flagellatus KT."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KT / ATCC 51484 / DSM 6875.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000284 Genomic DNA. Translation: ABE49040.1.
RefSeqYP_544881.1. NC_007947.1.

3D structure databases

ProteinModelPortalQ1H397.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1H397.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4000628.
GenomeReviewsGene locus Mfla_0772 in contig CP000284_GR.
KEGGmfa:Mfla_0772.
NMPDRfig|265072.7.peg.774.
PATRIC32267131. VBIMetFla97085_0803.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMAIRPAKSA.
PhylomeDBQ1H397.

Enzyme and pathway databases

BioCycMFLA265072:MFLA_0772-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_METFK
AccessionPrimary (citable) accession number: Q1H397
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 27, 2006
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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