Q1H384 (GLMM_METFK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	Mfla_0785

Organism

Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) [Complete proteome] [HAMAP]

Taxonomic identifier

265072 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_0000301338
Sites
	Active site	108	1	Phosphoserine intermediate By similarity
	Metal binding	108	1	Magnesium; via phosphate group By similarity
	Metal binding	247	1	Magnesium By similarity
	Metal binding	249	1	Magnesium By similarity
	Metal binding	251	1	Magnesium By similarity
Amino acid modifications
	Modified residue	108	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1H384 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: BC1A89917BE99A2D	FASTA	453	48,525
	10 20 30 40 50 60 MSRKYFGTDG VRGKVGTFPI TPDFVMRLGY AAGRVLTRMD HHLVPGTKPL VIIGKDTRIS 70 80 90 100 110 120 GYMFETALVS GLCAGGVNVR ITGPLPTPAI AHVTRAQRAQ AGIVISASHN PFDDNGIKFF 130 140 150 160 170 180 SAQGTKLPDE VELAIEAELD QPMELVPTEQ IGRVKRIDDA AGRYIEFCKS TFPNALDLRG 190 200 210 220 230 240 LKIVLDCANG ATYHVAPPVF HELGAEVISI GTQPNGLNIN LNVGSTHPES LQQAVVEHQA 250 260 270 280 290 300 DLGIAFDGDG DRVVMADNQG QLLDGDQLLY IIASHRHQRG RLGGGVVGTL MTNLALEHAL 310 320 330 340 350 360 GKEGIPFQRA KVGDRYVLEL LNANEWQLGG ENSGHILCLD KHSSGDGIIA ALQVLHALRA 370 380 390 400 410 420 SGLSLADWAK RLPLYPQVLI NVKVAQRIDL DSNTALQAAV TSAEGALKGT GRVLLRASGT 430 440 450 EPKIRVMVEG QDRPLVQRLA EEIAAVVQQE AAS

References

[1]

"Complete sequence of Methylobacillus flagellatus KT." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. , Larimer F., Land M., Kyrpides N., Anderson I., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KT / ATCC 51484 / DSM 6875.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000284 Genomic DNA. Translation: ABE49053.1.
RefSeq	YP_544894.1. NC_007947.1.
3D structure databases
ProteinModelPortal	Q1H384.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1H384.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4000641.
GenomeReviews	Gene locus Mfla_0785 in contig CP000284_GR.
KEGG	mfa:Mfla_0785.
NMPDR	fig|265072.7.peg.788.
PATRIC	32267159. VBIMetFla97085_0817.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HBG644964.
OMA	PLEDIQV.
PhylomeDB	Q1H384.
ProtClustDB	CLSK2529299.
Enzyme and pathway databases
BioCyc	MFLA265072:MFLA_0785-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_METFK

Accession

Primary (citable) accession number: Q1H384

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program