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Q1H378 (DADA_METFK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-amino acid dehydrogenase small subunit
EC=1.4.99.1
Gene names
Name:dadA
Ordered Locus Names:Mfla_0791
OrganismMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) [Complete proteome] [HAMAP]
Taxonomic identifier265072 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Oxidative deamination of D-amino acids By similarity. HAMAP MF_01202

Catalytic activity

A D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. HAMAP MF_01202

Cofactor

FAD By similarity. HAMAP MF_01202

Pathway

Amino-acid degradation; D-alanine degradation; NH(3) and pyruvate from D-alanine: step 1/1. HAMAP MF_01202

Subunit structure

Heterodimer of a small and a large subunit By similarity.

Sequence similarities

Belongs to the DadA oxidoreductase family.

Ontologies

Keywords
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionD-amino-acid dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417D-amino acid dehydrogenase small subunit HAMAP MF_01202
PRO_1000066099

Regions

Nucleotide binding3 – 1715FAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q1H378 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: CF39A276952DE939

FASTA41745,859
        10         20         30         40         50         60 
MKVIVLGSGV IGVTAAWYLA EAGHEVIVLD RQPGPALETS YANAGQVSPG YASPWAAPGI 

        70         80         90        100        110        120 
PLKAIKWMLR RHAPLFIKPD GTWQQLRWMW QLLQNCTGTR YEQNKARMVR LAEYSRDCLD 

       130        140        150        160        170        180 
QLRADTGIEY EGRQRGTLQL FRTREQLDAA LRDIEVLRFA HVPFELLPPS LLTKAEPALE 

       190        200        210        220        230        240 
HVKHKLTGGL WLPRDETGDC RLFTVRLADM AAARGVQFRY GQEISHLAIE SGNVNGVVVS 

       250        260        270        280        290        300 
GVRVQADAYV VALAAYSVDV LKGVLDLPVY PVKGYSITVP IIDEALAPVS TVLDETYKTA 

       310        320        330        340        350        360 
VTRFDNRIRV GGMAELVGFD RRLSPRREGT LKLIVHDLFP GAADLSQTSF WTGLRPMTPD 

       370        380        390        400        410 
GPPIIGATPI PNLYLNTGHG TLGWTMACGS GKLLADIISG KKTDIQHDDL GIGRYAK

« Hide

References

[1]"Complete sequence of Methylobacillus flagellatus KT."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KT / ATCC 51484 / DSM 6875.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000284 Genomic DNA. Translation: ABE49059.1.
RefSeqYP_544900.1. NC_007947.1.

3D structure databases

ProteinModelPortalQ1H378.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1H378.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4000224.
GenomeReviewsGene locus Mfla_0791 in contig CP000284_GR.
KEGGmfa:Mfla_0791.
PATRIC32267171. VBIMetFla97085_0823.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0665.
HOGENOMHBG729204.
OMAVDRQPAV.
PhylomeDBQ1H378.
ProtClustDBPRK00711.

Enzyme and pathway databases

BioCycMFLA265072:MFLA_0791-MONOMER.

Family and domain databases

HAMAPMF_01202. DadA.
[Tree]
InterProIPR023080. D-aa_DH_ssu_DadA.
IPR006076. FAD-dep_OxRdtase.
[Graphical view]
KOK00285.
PfamPF01266. DAO. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDADA_METFK
AccessionPrimary (citable) accession number: Q1H378
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 27, 2006
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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