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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 3531Proton donorUniRule annotation
Active sitei384 – 3841UniRule annotation
Active sitei516 – 5161UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMFLA265072:GHWJ-1355-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Mfla_1325
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
ProteomesiUP000002440 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Glucose-6-phosphate isomerasePRO_0000252630Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_1325.

Structurei

3D structure databases

ProteinModelPortaliQ1H1P4.
SMRiQ1H1P4. Positions 5-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1H1P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNPTNCPIW HDLSAHYQEV LPLQMRDMFT KDGRRFEKFS LEAEGLLLDY
60 70 80 90 100
SKHRITDETL PLLFKLARDS KVEEWRDRMF AGEKINFTEN RAVLHTALRN
110 120 130 140 150
RSNTPVYVDG KDVMPDVNRV LAQMRKFSTS IRSGEWKGYS GKRITDVVNI
160 170 180 190 200
GIGGSDLGPV MVCGALKPYA QAGLNAHFVS NIDGTHLAQT LERCDPETTL
210 220 230 240 250
FIVASKTFTT QETMTNARSA RSWFLQAAKD EAHVAKHFVA ISTNADEVGK
260 270 280 290 300
FGIDAANMFE FWDWVGGRYS LWSAIGLSIA IYIGMDHFEE LLQGGYEIDR
310 320 330 340 350
HFKNAPLEQN IPVIMALLGI WYNNFFGADS LAILPYDQGL ARFPAYLQQA
360 370 380 390 400
DMESNGKFVA RDGRIVQCTT GPIIWGEAGT NGQHAFYQLI HQGNRLIPCD
410 420 430 440 450
FMMPLQSHYS MGKNGNEHHL ILLANCFAQT SALMQGKTLD EAKAELVAQG
460 470 480 490 500
LTGEALETLL PHKVFEGNRP STTILFDKLT PKTLGKLIAI YEHKIFVQGI
510 520 530 540 550
IWNINSFDQW GVEYGKQIAK KILPQLSEDQ ASTEYDSSTN GLMNYFKSRT

QSSGT
Length:555
Mass (Da):62,321
Last modified:October 17, 2006 - v2
Checksum:iC2A8DA65993DB616
GO

Sequence cautioni

The sequence ABE49593.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE49593.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABE49593; ABE49593; Mfla_1325.
KEGGimfa:Mfla_1325.
PATRICi32268357. VBIMetFla97085_1411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE49593.1. Different initiation.

3D structure databases

ProteinModelPortaliQ1H1P4.
SMRiQ1H1P4. Positions 5-552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi265072.Mfla_1325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE49593; ABE49593; Mfla_1325.
KEGGimfa:Mfla_1325.
PATRICi32268357. VBIMetFla97085_1411.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciMFLA265072:GHWJ-1355-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT / ATCC 51484 / DSM 6875.

Entry informationi

Entry nameiG6PI_METFK
AccessioniPrimary (citable) accession number: Q1H1P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.