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Q1H1P4 (G6PI_METFK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:Mfla_1325
OrganismMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) [Complete proteome] [HAMAP]
Taxonomic identifier265072 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence ABE49593.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000252630

Sites

Active site3531Proton donor By similarity
Active site3841 By similarity
Active site5161 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1H1P4 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: C2A8DA65993DB616

FASTA55562,321
        10         20         30         40         50         60 
MTNPTNCPIW HDLSAHYQEV LPLQMRDMFT KDGRRFEKFS LEAEGLLLDY SKHRITDETL 

        70         80         90        100        110        120 
PLLFKLARDS KVEEWRDRMF AGEKINFTEN RAVLHTALRN RSNTPVYVDG KDVMPDVNRV 

       130        140        150        160        170        180 
LAQMRKFSTS IRSGEWKGYS GKRITDVVNI GIGGSDLGPV MVCGALKPYA QAGLNAHFVS 

       190        200        210        220        230        240 
NIDGTHLAQT LERCDPETTL FIVASKTFTT QETMTNARSA RSWFLQAAKD EAHVAKHFVA 

       250        260        270        280        290        300 
ISTNADEVGK FGIDAANMFE FWDWVGGRYS LWSAIGLSIA IYIGMDHFEE LLQGGYEIDR 

       310        320        330        340        350        360 
HFKNAPLEQN IPVIMALLGI WYNNFFGADS LAILPYDQGL ARFPAYLQQA DMESNGKFVA 

       370        380        390        400        410        420 
RDGRIVQCTT GPIIWGEAGT NGQHAFYQLI HQGNRLIPCD FMMPLQSHYS MGKNGNEHHL 

       430        440        450        460        470        480 
ILLANCFAQT SALMQGKTLD EAKAELVAQG LTGEALETLL PHKVFEGNRP STTILFDKLT 

       490        500        510        520        530        540 
PKTLGKLIAI YEHKIFVQGI IWNINSFDQW GVEYGKQIAK KILPQLSEDQ ASTEYDSSTN 

       550 
GLMNYFKSRT QSSGT 

« Hide

References

[1]"Complete sequence of Methylobacillus flagellatus KT."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KT / ATCC 51484 / DSM 6875.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000284 Genomic DNA. Translation: ABE49593.1. Different initiation.
RefSeqYP_545434.1. NC_007947.1.

3D structure databases

ProteinModelPortalQ1H1P4.
SMRQ1H1P4. Positions 5-552.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING265072.Mfla_1325.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE49593; ABE49593; Mfla_1325.
GeneID4000036.
KEGGmfa:Mfla_1325.
PATRIC32268357. VBIMetFla97085_1411.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycMFLA265072:GHWJ-1355-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_METFK
AccessionPrimary (citable) accession number: Q1H1P4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways