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Protein

Alanine racemase

Gene

alr

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Active sitei253Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei301Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:Mfla_1331
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesMethylophilaceaeMethylobacillus
Proteomesi
  • UP000002440 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000660091 – 357Alanine racemaseAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_1331.

Structurei

3D structure databases

ProteinModelPortaliQ1H1N8.
SMRiQ1H1N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031446.
KOiK01775.
OMAiISHFACA.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1H1N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRATTATIDL GALRHNLNLV RQRAPGSRVL AVVKADAYGH GLLRVAPGLA
60 70 80 90 100
EADGFGVLRL EEALALREAG YRQRLLLLEG IFSMDELGAA AQHGISVVVH
110 120 130 140 150
NAQQLAMFEA MAAASVKPIS VFLKMNSGMN RLGFKSQAYK QALQRLEACP
160 170 180 190 200
VVADVSLMTH FATADEERGI ADQLKEFDAV TAGWHHPVSL ANSAAILRFP
210 220 230 240 250
EAHRDWVRPG IILYGASPVS GVSAASFGLR PAMRFTSEVI AVQTLEAGDI
260 270 280 290 300
LGYGARFTAT QATRVAIVAC GYADGYPRHA PNGTPIAIDG HRTQTLGRVS
310 320 330 340 350
MDMLFADISQ LPDADVGSQV ELWGEVVPVD AVAEAAGTVG YELLCAVAPR

VVFKVTG
Length:357
Mass (Da):37,954
Last modified:June 27, 2006 - v1
Checksum:i1F2170F0A63FAE30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE49599.1.
RefSeqiWP_011479553.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE49599; ABE49599; Mfla_1331.
KEGGimfa:Mfla_1331.

Similar proteinsi

Entry informationi

Entry nameiALR_METFK
AccessioniPrimary (citable) accession number: Q1H1N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 27, 2006
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families