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Q1H152

- LPXB_METFK

UniProt

Q1H152 - LPXB_METFK

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciMFLA265072:GHWJ-1554-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Mfla_1517
    OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
    Taxonomic identifieri265072 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
    ProteomesiUP000002440: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378Lipid-A-disaccharide synthasePRO_0000255198Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi265072.Mfla_1517.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1H152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1H152-1 [UniParc]FASTAAdd to Basket

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    MPTIGIVAGE ASGDLLGSHL IRALKKQRPD LKFVGIAGPK MIAEGAETLF    50
    PMERLSVRGY VEVLRHLPGL LKIRKEVAQY FLDHRPDVFI GIDAPDFNFT 100
    LERKLKHQGI PTVHYVSPSI WAWRRGKIKK IQQAVSHMLA LFPFEPEIYR 150
    QAGVAVSYVG HPLADMLPME PDMEGAREEL KLPQDSLVVA MLPGSRQSEV 200
    QQLADLYIKT AKLILSERPD ARFLVPLITR ETRAIFERAL YANEGYDLPV 250
    SIMFGHAHQA MEAANAVIVA SGTATLEAAL IKRPMIITYR MPNLSWQILK 300
    RMKYLPYVGL PNVLAGRFIV PELLQHDAVP DKLAATLLQM LSDKSQIADI 350
    QTEFRRMHEL LRQNTEEKAA RAVLSFIK 378
    Length:378
    Mass (Da):42,525
    Last modified:June 27, 2006 - v1
    Checksum:i3DECB4CCF6E36D31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE49785.1.
    RefSeqiWP_011479739.1. NC_007947.1.
    YP_545626.1. NC_007947.1.

    Genome annotation databases

    EnsemblBacteriaiABE49785; ABE49785; Mfla_1517.
    GeneIDi4000831.
    KEGGimfa:Mfla_1517.
    PATRICi32268767. VBIMetFla97085_1610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE49785.1 .
    RefSeqi WP_011479739.1. NC_007947.1.
    YP_545626.1. NC_007947.1.

    3D structure databases

    ProteinModelPortali Q1H152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265072.Mfla_1517.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE49785 ; ABE49785 ; Mfla_1517 .
    GeneIDi 4000831.
    KEGGi mfa:Mfla_1517.
    PATRICi 32268767. VBIMetFla97085_1610.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci MFLA265072:GHWJ-1554-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT / ATCC 51484 / DSM 6875.

    Entry informationi

    Entry nameiLPXB_METFK
    AccessioniPrimary (citable) accession number: Q1H152
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3