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Q1H152

- LPXB_METFK

UniProt

Q1H152 - LPXB_METFK

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMFLA265072:GHWJ-1554-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Mfla_1517
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
ProteomesiUP000002440: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Lipid-A-disaccharide synthasePRO_0000255198Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_1517.

Structurei

3D structure databases

ProteinModelPortaliQ1H152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1H152-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTIGIVAGE ASGDLLGSHL IRALKKQRPD LKFVGIAGPK MIAEGAETLF
60 70 80 90 100
PMERLSVRGY VEVLRHLPGL LKIRKEVAQY FLDHRPDVFI GIDAPDFNFT
110 120 130 140 150
LERKLKHQGI PTVHYVSPSI WAWRRGKIKK IQQAVSHMLA LFPFEPEIYR
160 170 180 190 200
QAGVAVSYVG HPLADMLPME PDMEGAREEL KLPQDSLVVA MLPGSRQSEV
210 220 230 240 250
QQLADLYIKT AKLILSERPD ARFLVPLITR ETRAIFERAL YANEGYDLPV
260 270 280 290 300
SIMFGHAHQA MEAANAVIVA SGTATLEAAL IKRPMIITYR MPNLSWQILK
310 320 330 340 350
RMKYLPYVGL PNVLAGRFIV PELLQHDAVP DKLAATLLQM LSDKSQIADI
360 370
QTEFRRMHEL LRQNTEEKAA RAVLSFIK
Length:378
Mass (Da):42,525
Last modified:June 27, 2006 - v1
Checksum:i3DECB4CCF6E36D31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE49785.1.
RefSeqiYP_545626.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE49785; ABE49785; Mfla_1517.
GeneIDi4000831.
KEGGimfa:Mfla_1517.
PATRICi32268767. VBIMetFla97085_1610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE49785.1 .
RefSeqi YP_545626.1. NC_007947.1.

3D structure databases

ProteinModelPortali Q1H152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 265072.Mfla_1517.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE49785 ; ABE49785 ; Mfla_1517 .
GeneIDi 4000831.
KEGGi mfa:Mfla_1517.
PATRICi 32268767. VBIMetFla97085_1610.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci MFLA265072:GHWJ-1554-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT / ATCC 51484 / DSM 6875.

Entry informationi

Entry nameiLPXB_METFK
AccessioniPrimary (citable) accession number: Q1H152
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 27, 2006
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3