Q1H151 (Q1H151_METFK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387
Short name=UDP-N-acetylglucosamine acyltransferase HAMAP MF_00387
EC=2.3.1.129 HAMAP MF_00387

Gene names

Name:	lpxA HAMAP MF_00387
Ordered Locus Names:	Mfla_1518

Organism

Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) [Complete proteome] [HAMAP] EMBL ABE49786.1

Taxonomic identifier

265072 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387
Subunit structure	Homotrimer By similarity. HAMAP MF_00387
Subcellular location	Cytoplasm By similarity HAMAP MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily. HAMAP MF_00387

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00387 Lipid synthesis
Cellular component	Cytoplasm HAMAP MF_00387
Domain	Repeat HAMAP MF_00387
Molecular function	Acyltransferase HAMAP MF_00387 EMBL ABE49786.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q1H151 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: 495FCAB58DF74F5F	FASTA	260	28,428
	10 20 30 40 50 60 MTEPRIHPTA IIDSRAELDS SVEVGAFTII GPDVRIGAGT RVASHVVIKG PTTIGRDNQI 70 80 90 100 110 120 FQYSSLGEVP QDKKFKNEPT LLEIGDGNTI REFCTFNRGT VQDKGTTKIG SHNWIMAYVH 130 140 150 160 170 180 IAHDCVVGDH TIFANNSSLA GHVDVHDHAI LGGFTLIHQF CKIGSHVITA VGSVVFKDIP 190 200 210 220 230 240 PYVTAAGYDA KPHGINSEGL KRRGFSADNI LQIKRAYKTL YRNGLTLEEA KQQLAEQSKT 250 260 SPELNILVDF LNQSTRGIVR

References

[1]

"Complete sequence of Methylobacillus flagellatus KT." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. , Larimer F., Land M., Kyrpides N., Anderson I., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KT / ATCC 51484 / DSM 6875.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000284 Genomic DNA. Translation: ABE49786.1.
RefSeq	YP_545627.1. NC_007947.1.
3D structure databases
ProteinModelPortal	Q1H151.
SMR	Q1H151. Positions 3-260.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1H151.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4000832.
GenomeReviews	Gene locus Mfla_1518 in contig CP000284_GR.
KEGG	mfa:Mfla_1518.
NMPDR	fig|265072.7.peg.1540.
PATRIC	32268769. VBIMetFla97085_1611.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1043.
HOGENOM	HBG659295.
OMA	REFCTFN.
PhylomeDB	Q1H151.
Family and domain databases
HAMAP	MF_00387. LpxA. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00677.
Pfam	PF00132. Hexapep. 3 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. Lipid_A_lpxA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q1H151_METFK

Accession

Primary (citable) accession number: Q1H151

Entry history

Integrated into UniProtKB/TrEMBL:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)