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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168UniRule annotation1
Active sitei194UniRule annotation1
Active sitei290UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:Mfla_1930
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesMethylophilaceaeMethylobacillus
Proteomesi
  • UP000002440 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642901 – 355Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_1930.

Structurei

3D structure databases

ProteinModelPortaliQ1GZZ0.
SMRiQ1GZZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini156 – 348CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OMAiMLEMHRA.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GZZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIKVLIIDD SALIRSLLTE IINQQPDLEV VGTAPDPLIA REMIKQKNPD
60 70 80 90 100
VLTLDVEMPK MDGLDFLERL MRLRPMPVVM ISSLTERGSE ITMRAMELGA
110 120 130 140 150
VDFVTKPKIS IANGMHEYSE MIADKIRAAS RARLIARKPL TPVAGGAGLP
160 170 180 190 200
LVGNPLISSE KLIIIGASTG GTEAIKSFLM QMPSDCPGIL ITQHMPAGFT
210 220 230 240 250
QSFANRLNAL CKISVQEAKG GERVLPGHAY IAPGHSHLLL ARSGANYVTQ
260 270 280 290 300
LDDGPPVSRH RPSVDVLFSS AANNAGKNAI GVILTGMGKD GAEGMLKMKQ
310 320 330 340 350
AGAYNFAQDE ASCVVFGMPK EAIAMGGVDD VSSLNDMPGR VLQYLAANSG

RALRV
Length:355
Mass (Da):37,881
Last modified:June 27, 2006 - v1
Checksum:i85B5C0FD5CF30F34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE50197.1.
RefSeqiWP_011480151.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE50197; ABE50197; Mfla_1930.
KEGGimfa:Mfla_1930.

Similar proteinsi

Entry informationi

Entry nameiCHEB_METFK
AccessioniPrimary (citable) accession number: Q1GZZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 27, 2006
Last modified: November 22, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome