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Q1GZE8 (PSD_METFK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:Mfla_2122
OrganismMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) [Complete proteome] [HAMAP]
Taxonomic identifier265072 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00662

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00662

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00662

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Phosphatidylserine decarboxylase beta chain By similarity
PRO_0000262123
Chain248 – 28033Phosphatidylserine decarboxylase alpha chain By similarity
PRO_0000262124

Sites

Site247 – 2482Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2481Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1GZE8 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: EB866D66942F7A60

FASTA28031,286
        10         20         30         40         50         60 
MPKPYSVKLQ YLVPKIALTA LAGKLAHLRA GWLTTTVIRW FAKHYRVNML EAVNPDITSY 

        70         80         90        100        110        120 
ASFNDFFTRA LKPGARPLAD AAQLCPVDGA ISQFGRIDKD QIFQAKGHHY STTALLAGNA 

       130        140        150        160        170        180 
QMAREYENGY FATIYLSPRD YHRIHMPCDG KLLSMTYVPG DLFSVNPLTA EHVPGLFARN 

       190        200        210        220        230        240 
ERVVCEFANS EGKFALVLVG ATIVGSMATV WHGIVNPPRR GEIQTWHYHD QDIRLKQGEE 

       250        260        270        280 
MGRFLLGSTV VVLYPETAQL RFQPGWHPLR AVSLGEAMAQ

« Hide

References

[1]"Complete sequence of Methylobacillus flagellatus KT."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KT / ATCC 51484 / DSM 6875.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000284 Genomic DNA. Translation: ABE50389.1.
RefSeqYP_546230.1. NC_007947.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ1GZE8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3999931.
GenomeReviewsGene locus Mfla_2122 in contig CP000284_GR.
KEGGmfa:Mfla_2122.
NMPDRfig|265072.7.peg.2146.
PATRIC32270045. VBIMetFla97085_2233.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0688.
HOGENOMHBG302256.
OMASMATVWH.
PhylomeDBQ1GZE8.
ProtClustDBPRK00044.

Enzyme and pathway databases

BioCycMFLA265072:MFLA_2122-MONOMER.

Family and domain databases

HAMAPMF_00662. PS_decarb_type1.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view]
KOK01613.
PANTHERPTHR10067. PS_decarb. 1 hit.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00163. PS_decarb. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_METFK
AccessionPrimary (citable) accession number: Q1GZE8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 27, 2006
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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