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Q1GZD6

- GCH4_METFK

UniProt

Q1GZD6 - GCH4_METFK

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Mfla_2134
Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei153 – 1531May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMFLA265072:GHWJ-2191-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Mfla_2134
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
ProteomesiUP000002440: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266GTP cyclohydrolase FolE2UniRule annotationPRO_0000289498Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_2134.

Structurei

3D structure databases

ProteinModelPortaliQ1GZD6.
SMRiQ1GZD6. Positions 20-264.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GZD6-1 [UniParc]FASTAAdd to Basket

« Hide

MNQPSIPPIE DVQNTPDTRQ LAIDKVGIKS IRHPVKVKDK TGGVQHTVAT    50
FNMYVYLPHN FKGTHMSRFV EILNNNEREI SVESFESILR AMVERLDAES 100
GHVEMTFPYF VNKTAPVSGV QSLSDYEVTF IGEINKGKYD ITVKVVVPVT 150
SLCPCSKKIS DYGAHNQRSH VTVTALINDF IWVEDIIRMV EDQASCEVYG 200
LLKRPDEKYV TERAYDNPKF VEDIVRDVAA QLNIETRIVS YTVESENFES 250
IHNHSAYALI EKDKRK 266
Length:266
Mass (Da):30,297
Last modified:June 27, 2006 - v1
Checksum:i226C7D4E493F4569
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000284 Genomic DNA. Translation: ABE50401.1.
RefSeqiYP_546242.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE50401; ABE50401; Mfla_2134.
GeneIDi3999943.
KEGGimfa:Mfla_2134.
PATRICi32270067. VBIMetFla97085_2244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000284 Genomic DNA. Translation: ABE50401.1 .
RefSeqi YP_546242.1. NC_007947.1.

3D structure databases

ProteinModelPortali Q1GZD6.
SMRi Q1GZD6. Positions 20-264.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 265072.Mfla_2134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE50401 ; ABE50401 ; Mfla_2134 .
GeneIDi 3999943.
KEGGi mfa:Mfla_2134.
PATRICi 32270067. VBIMetFla97085_2244.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci MFLA265072:GHWJ-2191-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT / ATCC 51484 / DSM 6875.

Entry informationi

Entry nameiGCH4_METFK
AccessioniPrimary (citable) accession number: Q1GZD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 27, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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