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Q1GZD6

- GCH4_METFK

UniProt

Q1GZD6 - GCH4_METFK

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei153 – 1531May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciMFLA265072:GHWJ-2191-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Mfla_2134
    OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
    Taxonomic identifieri265072 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
    ProteomesiUP000002440: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266GTP cyclohydrolase FolE2PRO_0000289498Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi265072.Mfla_2134.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GZD6.
    SMRiQ1GZD6. Positions 20-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GZD6-1 [UniParc]FASTAAdd to Basket

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    MNQPSIPPIE DVQNTPDTRQ LAIDKVGIKS IRHPVKVKDK TGGVQHTVAT    50
    FNMYVYLPHN FKGTHMSRFV EILNNNEREI SVESFESILR AMVERLDAES 100
    GHVEMTFPYF VNKTAPVSGV QSLSDYEVTF IGEINKGKYD ITVKVVVPVT 150
    SLCPCSKKIS DYGAHNQRSH VTVTALINDF IWVEDIIRMV EDQASCEVYG 200
    LLKRPDEKYV TERAYDNPKF VEDIVRDVAA QLNIETRIVS YTVESENFES 250
    IHNHSAYALI EKDKRK 266
    Length:266
    Mass (Da):30,297
    Last modified:June 27, 2006 - v1
    Checksum:i226C7D4E493F4569
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE50401.1.
    RefSeqiYP_546242.1. NC_007947.1.

    Genome annotation databases

    EnsemblBacteriaiABE50401; ABE50401; Mfla_2134.
    GeneIDi3999943.
    KEGGimfa:Mfla_2134.
    PATRICi32270067. VBIMetFla97085_2244.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE50401.1 .
    RefSeqi YP_546242.1. NC_007947.1.

    3D structure databases

    ProteinModelPortali Q1GZD6.
    SMRi Q1GZD6. Positions 20-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265072.Mfla_2134.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE50401 ; ABE50401 ; Mfla_2134 .
    GeneIDi 3999943.
    KEGGi mfa:Mfla_2134.
    PATRICi 32270067. VBIMetFla97085_2244.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci MFLA265072:GHWJ-2191-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT / ATCC 51484 / DSM 6875.

    Entry informationi

    Entry nameiGCH4_METFK
    AccessioniPrimary (citable) accession number: Q1GZD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3