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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei153 – 1531May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMFLA265072:GHWJ-2191-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Mfla_2134
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
ProteomesiUP000002440: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266GTP cyclohydrolase FolE2PRO_0000289498Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_2134.

Structurei

3D structure databases

ProteinModelPortaliQ1GZD6.
SMRiQ1GZD6. Positions 20-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GZD6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQPSIPPIE DVQNTPDTRQ LAIDKVGIKS IRHPVKVKDK TGGVQHTVAT
60 70 80 90 100
FNMYVYLPHN FKGTHMSRFV EILNNNEREI SVESFESILR AMVERLDAES
110 120 130 140 150
GHVEMTFPYF VNKTAPVSGV QSLSDYEVTF IGEINKGKYD ITVKVVVPVT
160 170 180 190 200
SLCPCSKKIS DYGAHNQRSH VTVTALINDF IWVEDIIRMV EDQASCEVYG
210 220 230 240 250
LLKRPDEKYV TERAYDNPKF VEDIVRDVAA QLNIETRIVS YTVESENFES
260
IHNHSAYALI EKDKRK
Length:266
Mass (Da):30,297
Last modified:June 27, 2006 - v1
Checksum:i226C7D4E493F4569
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE50401.1.
RefSeqiWP_011480355.1. NC_007947.1.
YP_546242.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE50401; ABE50401; Mfla_2134.
GeneIDi3999943.
KEGGimfa:Mfla_2134.
PATRICi32270067. VBIMetFla97085_2244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE50401.1.
RefSeqiWP_011480355.1. NC_007947.1.
YP_546242.1. NC_007947.1.

3D structure databases

ProteinModelPortaliQ1GZD6.
SMRiQ1GZD6. Positions 20-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi265072.Mfla_2134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE50401; ABE50401; Mfla_2134.
GeneIDi3999943.
KEGGimfa:Mfla_2134.
PATRICi32270067. VBIMetFla97085_2244.

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BioCyciMFLA265072:GHWJ-2191-MONOMER.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT / ATCC 51484 / DSM 6875.

Entry informationi

Entry nameiGCH4_METFK
AccessioniPrimary (citable) accession number: Q1GZD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 27, 2006
Last modified: February 4, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.