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Q1GZB5

- SYL_METFK

UniProt

Q1GZB5 - SYL_METFK

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMFLA265072:GHWJ-2212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mfla_2155
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
ProteomesiUP000002440: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817Leucine--tRNA ligasePRO_1000009372Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_2155.

Structurei

3D structure databases

ProteinModelPortaliQ1GZB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GZB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQQQYPFRDI EQQAQQYWES NATFTATEVS DKPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLSRFHRMRG YNVMQPMGWD AFGLPAENAA IKHNVAPAGW
110 120 130 140 150
TYSNIEHMKG QLKSLGLAVD WQREIATCKP DYYRWEQWLF TELYKKGLIY
160 170 180 190 200
KKTATVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKRDIPQ YFMKITAYAE
210 220 230 240 250
ELLADLDKLD GWPEQVKTMQ RNWIGKSYGC EVEFPLAVGN GTLKVYTTRP
260 270 280 290 300
DTLMGATYVA IAAEHALATQ AAKDNPALQA FIEECKRGSV AEADLATAEK
310 320 330 340 350
KGMNSGLFVL HPITGEKLPV WVANYVLISY GEGAVMAVPA HDERDFEFAS
360 370 380 390 400
KYKLPIKAVI KPAHGELELP LQAAYTEHGI LFDSGDFNGL DFSQASDAIA
410 420 430 440 450
AALAAKNLGK RRTQYRLRDW GISRQRYWGC PIPIVHCPSC GEVPVPAEQL
460 470 480 490 500
PVVLPEDVVM DGVGSPIKKD PAFYETTCPS CGEKATRETD TMDTFVESSW
510 520 530 540 550
YFARYASFDA HSSMVDERAN YWLPVDQYIG GIEHAILHLL YARFFNKLMR
560 570 580 590 600
DVGLVRHDEP FTKLLTQGMV LKDGSKMSKS KGNTVDPQEL IDNYGADTAR
610 620 630 640 650
LFMMFAAPPE QSLEWSDAGV EGAHRFLKRV WTAVANHVES GIVAAFTMGD
660 670 680 690 700
LSAELKAFRR QLHQTIEKVT DDYGRRHAFN TAIAAVMELM NAYAKIEGHD
710 720 730 740 750
ATTRAIRQEA LENIILLLSP IVPHICHALW QALRPGTQLL DTRWPVANKA
760 770 780 790 800
AMVQDEIELV LQVNGKLRGS MTVSRTLDKA AIEALAVQQE CIQKYLAEGS
810
VRKIIVVPNK LVNIVVG
Length:817
Mass (Da):91,608
Last modified:June 27, 2006 - v1
Checksum:iFE410E4C7D9E64DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE50422.1.
RefSeqiWP_011480376.1. NC_007947.1.
YP_546263.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE50422; ABE50422; Mfla_2155.
GeneIDi3999711.
KEGGimfa:Mfla_2155.
PATRICi32270111. VBIMetFla97085_2266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE50422.1 .
RefSeqi WP_011480376.1. NC_007947.1.
YP_546263.1. NC_007947.1.

3D structure databases

ProteinModelPortali Q1GZB5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 265072.Mfla_2155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE50422 ; ABE50422 ; Mfla_2155 .
GeneIDi 3999711.
KEGGi mfa:Mfla_2155.
PATRICi 32270111. VBIMetFla97085_2266.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MFLA265072:GHWJ-2212-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT / ATCC 51484 / DSM 6875.

Entry informationi

Entry nameiSYL_METFK
AccessioniPrimary (citable) accession number: Q1GZB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3