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Q1GZB5

- SYL_METFK

UniProt

Q1GZB5 - SYL_METFK

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMFLA265072:GHWJ-2212-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mfla_2155
    OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
    Taxonomic identifieri265072 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
    ProteomesiUP000002440: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 817817Leucine--tRNA ligasePRO_1000009372Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi265072.Mfla_2155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GZB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GZB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQQYPFRDI EQQAQQYWES NATFTATEVS DKPKYYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VLSRFHRMRG YNVMQPMGWD AFGLPAENAA IKHNVAPAGW 100
    TYSNIEHMKG QLKSLGLAVD WQREIATCKP DYYRWEQWLF TELYKKGLIY 150
    KKTATVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKRDIPQ YFMKITAYAE 200
    ELLADLDKLD GWPEQVKTMQ RNWIGKSYGC EVEFPLAVGN GTLKVYTTRP 250
    DTLMGATYVA IAAEHALATQ AAKDNPALQA FIEECKRGSV AEADLATAEK 300
    KGMNSGLFVL HPITGEKLPV WVANYVLISY GEGAVMAVPA HDERDFEFAS 350
    KYKLPIKAVI KPAHGELELP LQAAYTEHGI LFDSGDFNGL DFSQASDAIA 400
    AALAAKNLGK RRTQYRLRDW GISRQRYWGC PIPIVHCPSC GEVPVPAEQL 450
    PVVLPEDVVM DGVGSPIKKD PAFYETTCPS CGEKATRETD TMDTFVESSW 500
    YFARYASFDA HSSMVDERAN YWLPVDQYIG GIEHAILHLL YARFFNKLMR 550
    DVGLVRHDEP FTKLLTQGMV LKDGSKMSKS KGNTVDPQEL IDNYGADTAR 600
    LFMMFAAPPE QSLEWSDAGV EGAHRFLKRV WTAVANHVES GIVAAFTMGD 650
    LSAELKAFRR QLHQTIEKVT DDYGRRHAFN TAIAAVMELM NAYAKIEGHD 700
    ATTRAIRQEA LENIILLLSP IVPHICHALW QALRPGTQLL DTRWPVANKA 750
    AMVQDEIELV LQVNGKLRGS MTVSRTLDKA AIEALAVQQE CIQKYLAEGS 800
    VRKIIVVPNK LVNIVVG 817
    Length:817
    Mass (Da):91,608
    Last modified:June 27, 2006 - v1
    Checksum:iFE410E4C7D9E64DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE50422.1.
    RefSeqiYP_546263.1. NC_007947.1.

    Genome annotation databases

    EnsemblBacteriaiABE50422; ABE50422; Mfla_2155.
    GeneIDi3999711.
    KEGGimfa:Mfla_2155.
    PATRICi32270111. VBIMetFla97085_2266.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE50422.1 .
    RefSeqi YP_546263.1. NC_007947.1.

    3D structure databases

    ProteinModelPortali Q1GZB5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265072.Mfla_2155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE50422 ; ABE50422 ; Mfla_2155 .
    GeneIDi 3999711.
    KEGGi mfa:Mfla_2155.
    PATRICi 32270111. VBIMetFla97085_2266.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MFLA265072:GHWJ-2212-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT / ATCC 51484 / DSM 6875.

    Entry informationi

    Entry nameiSYL_METFK
    AccessioniPrimary (citable) accession number: Q1GZB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3