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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMFLA265072:G1G69-2310-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mfla_2155
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesMethylophilaceaeMethylobacillus
Proteomesi
  • UP000002440 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093721 – 817Leucine--tRNA ligaseAdd BLAST817

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_2155

Structurei

3D structure databases

ProteinModelPortaliQ1GZB5
SMRiQ1GZB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.6202 hits
3.90.740.101 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q1GZB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQQYPFRDI EQQAQQYWES NATFTATEVS DKPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLSRFHRMRG YNVMQPMGWD AFGLPAENAA IKHNVAPAGW
110 120 130 140 150
TYSNIEHMKG QLKSLGLAVD WQREIATCKP DYYRWEQWLF TELYKKGLIY
160 170 180 190 200
KKTATVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKRDIPQ YFMKITAYAE
210 220 230 240 250
ELLADLDKLD GWPEQVKTMQ RNWIGKSYGC EVEFPLAVGN GTLKVYTTRP
260 270 280 290 300
DTLMGATYVA IAAEHALATQ AAKDNPALQA FIEECKRGSV AEADLATAEK
310 320 330 340 350
KGMNSGLFVL HPITGEKLPV WVANYVLISY GEGAVMAVPA HDERDFEFAS
360 370 380 390 400
KYKLPIKAVI KPAHGELELP LQAAYTEHGI LFDSGDFNGL DFSQASDAIA
410 420 430 440 450
AALAAKNLGK RRTQYRLRDW GISRQRYWGC PIPIVHCPSC GEVPVPAEQL
460 470 480 490 500
PVVLPEDVVM DGVGSPIKKD PAFYETTCPS CGEKATRETD TMDTFVESSW
510 520 530 540 550
YFARYASFDA HSSMVDERAN YWLPVDQYIG GIEHAILHLL YARFFNKLMR
560 570 580 590 600
DVGLVRHDEP FTKLLTQGMV LKDGSKMSKS KGNTVDPQEL IDNYGADTAR
610 620 630 640 650
LFMMFAAPPE QSLEWSDAGV EGAHRFLKRV WTAVANHVES GIVAAFTMGD
660 670 680 690 700
LSAELKAFRR QLHQTIEKVT DDYGRRHAFN TAIAAVMELM NAYAKIEGHD
710 720 730 740 750
ATTRAIRQEA LENIILLLSP IVPHICHALW QALRPGTQLL DTRWPVANKA
760 770 780 790 800
AMVQDEIELV LQVNGKLRGS MTVSRTLDKA AIEALAVQQE CIQKYLAEGS
810
VRKIIVVPNK LVNIVVG
Length:817
Mass (Da):91,608
Last modified:June 27, 2006 - v1
Checksum:iFE410E4C7D9E64DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA Translation: ABE50422.1
RefSeqiWP_011480376.1, NC_007947.1

Genome annotation databases

EnsemblBacteriaiABE50422; ABE50422; Mfla_2155
KEGGimfa:Mfla_2155

Similar proteinsi

Entry informationi

Entry nameiSYL_METFK
AccessioniPrimary (citable) accession number: Q1GZB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: February 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome