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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMFLA265072:GHWJ-2311-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Mfla_2254
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
ProteomesiUP000002440 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000293047Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_2254.

Structurei

3D structure databases

ProteinModelPortaliQ1GZ16.
SMRiQ1GZ16. Positions 4-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GZ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSDIEIARQ AKLRKISEIA AELGLNEDSI TLYGQYKAKI DLNANPQLQA
60 70 80 90 100
QPDGKLILVT AISPSPAGEG KTTTTVGLGD ALQRMGKRAV ICLREPSMGP
110 120 130 140 150
VFGMKGGAAG GGYAQVVPME DINLHFTGDF ASIALAHNLL AAMIDNHIHH
160 170 180 190 200
GNALQIDPRQ VTWKRVIDMN DRALRQVVIG LGGKVNGQPR EDGFDIVVAS
210 220 230 240 250
EVMAVFCLAD SLKDLRTRLG RIVVGYTYSG QPVTAQDLKA HGAMTVLLKD
260 270 280 290 300
AIKPNLVQTL EHTPALLHGG PFANIAHGCN SVIATRTALK LGDYVVTEAG
310 320 330 340 350
FGADLGAEKF IDIKCRKAGL HPDACVIVAT IRALKYHGGA DVSALSREDM
360 370 380 390 400
LALDRGIANL EKHVENVTTH YGMPAVIALN RFDHDTEAEL ALVMKRMGEM
410 420 430 440 450
GIKVVVAEHW AKGGAGAESL AAHVLQLIEG RSEGVRYVYE SSETLWEKVN
460 470 480 490 500
QVARKIYGAM DVHAPRPVRA MIDRLQDAGY GHYPICIAKT QYSFSTDASR
510 520 530 540 550
RGVPHEHILT VRAVRLCAGA EFVVIICDDI MTMPGLPEEP CAIRMDIDDD

GQVVGLY
Length:557
Mass (Da):60,157
Last modified:June 26, 2006 - v1
Checksum:i8C3936EB1B4889D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE50521.1.
RefSeqiWP_011480475.1. NC_007947.1.
YP_546362.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE50521; ABE50521; Mfla_2254.
GeneIDi3999810.
KEGGimfa:Mfla_2254.
PATRICi32270313. VBIMetFla97085_2367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE50521.1.
RefSeqiWP_011480475.1. NC_007947.1.
YP_546362.1. NC_007947.1.

3D structure databases

ProteinModelPortaliQ1GZ16.
SMRiQ1GZ16. Positions 4-555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi265072.Mfla_2254.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE50521; ABE50521; Mfla_2254.
GeneIDi3999810.
KEGGimfa:Mfla_2254.
PATRICi32270313. VBIMetFla97085_2367.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciMFLA265072:GHWJ-2311-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT / ATCC 51484 / DSM 6875.

Entry informationi

Entry nameiFTHS_METFK
AccessioniPrimary (citable) accession number: Q1GZ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2007
Last sequence update: June 26, 2006
Last modified: March 3, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.