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Q1GZ16

- FTHS_METFK

UniProt

Q1GZ16 - FTHS_METFK

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMFLA265072:GHWJ-2311-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Mfla_2254
    OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
    Taxonomic identifieri265072 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
    ProteomesiUP000002440: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000293047Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi265072.Mfla_2254.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GZ16.
    SMRiQ1GZ16. Positions 4-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiGIEHEAS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GZ16-1 [UniParc]FASTAAdd to Basket

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    MFSDIEIARQ AKLRKISEIA AELGLNEDSI TLYGQYKAKI DLNANPQLQA    50
    QPDGKLILVT AISPSPAGEG KTTTTVGLGD ALQRMGKRAV ICLREPSMGP 100
    VFGMKGGAAG GGYAQVVPME DINLHFTGDF ASIALAHNLL AAMIDNHIHH 150
    GNALQIDPRQ VTWKRVIDMN DRALRQVVIG LGGKVNGQPR EDGFDIVVAS 200
    EVMAVFCLAD SLKDLRTRLG RIVVGYTYSG QPVTAQDLKA HGAMTVLLKD 250
    AIKPNLVQTL EHTPALLHGG PFANIAHGCN SVIATRTALK LGDYVVTEAG 300
    FGADLGAEKF IDIKCRKAGL HPDACVIVAT IRALKYHGGA DVSALSREDM 350
    LALDRGIANL EKHVENVTTH YGMPAVIALN RFDHDTEAEL ALVMKRMGEM 400
    GIKVVVAEHW AKGGAGAESL AAHVLQLIEG RSEGVRYVYE SSETLWEKVN 450
    QVARKIYGAM DVHAPRPVRA MIDRLQDAGY GHYPICIAKT QYSFSTDASR 500
    RGVPHEHILT VRAVRLCAGA EFVVIICDDI MTMPGLPEEP CAIRMDIDDD 550
    GQVVGLY 557
    Length:557
    Mass (Da):60,157
    Last modified:June 27, 2006 - v1
    Checksum:i8C3936EB1B4889D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE50521.1.
    RefSeqiWP_011480475.1. NC_007947.1.
    YP_546362.1. NC_007947.1.

    Genome annotation databases

    EnsemblBacteriaiABE50521; ABE50521; Mfla_2254.
    GeneIDi3999810.
    KEGGimfa:Mfla_2254.
    PATRICi32270313. VBIMetFla97085_2367.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE50521.1 .
    RefSeqi WP_011480475.1. NC_007947.1.
    YP_546362.1. NC_007947.1.

    3D structure databases

    ProteinModelPortali Q1GZ16.
    SMRi Q1GZ16. Positions 4-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265072.Mfla_2254.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE50521 ; ABE50521 ; Mfla_2254 .
    GeneIDi 3999810.
    KEGGi mfa:Mfla_2254.
    PATRICi 32270313. VBIMetFla97085_2367.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi GIEHEAS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MFLA265072:GHWJ-2311-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT / ATCC 51484 / DSM 6875.

    Entry informationi

    Entry nameiFTHS_METFK
    AccessioniPrimary (citable) accession number: Q1GZ16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3