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Q1GZ16

- FTHS_METFK

UniProt

Q1GZ16 - FTHS_METFK

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Mfla_2254
Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMFLA265072:GHWJ-2311-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Mfla_2254
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
ProteomesiUP000002440: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000293047Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_2254.

Structurei

3D structure databases

ProteinModelPortaliQ1GZ16.
SMRiQ1GZ16. Positions 4-555.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GZ16-1 [UniParc]FASTAAdd to Basket

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MFSDIEIARQ AKLRKISEIA AELGLNEDSI TLYGQYKAKI DLNANPQLQA    50
QPDGKLILVT AISPSPAGEG KTTTTVGLGD ALQRMGKRAV ICLREPSMGP 100
VFGMKGGAAG GGYAQVVPME DINLHFTGDF ASIALAHNLL AAMIDNHIHH 150
GNALQIDPRQ VTWKRVIDMN DRALRQVVIG LGGKVNGQPR EDGFDIVVAS 200
EVMAVFCLAD SLKDLRTRLG RIVVGYTYSG QPVTAQDLKA HGAMTVLLKD 250
AIKPNLVQTL EHTPALLHGG PFANIAHGCN SVIATRTALK LGDYVVTEAG 300
FGADLGAEKF IDIKCRKAGL HPDACVIVAT IRALKYHGGA DVSALSREDM 350
LALDRGIANL EKHVENVTTH YGMPAVIALN RFDHDTEAEL ALVMKRMGEM 400
GIKVVVAEHW AKGGAGAESL AAHVLQLIEG RSEGVRYVYE SSETLWEKVN 450
QVARKIYGAM DVHAPRPVRA MIDRLQDAGY GHYPICIAKT QYSFSTDASR 500
RGVPHEHILT VRAVRLCAGA EFVVIICDDI MTMPGLPEEP CAIRMDIDDD 550
GQVVGLY 557
Length:557
Mass (Da):60,157
Last modified:June 27, 2006 - v1
Checksum:i8C3936EB1B4889D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000284 Genomic DNA. Translation: ABE50521.1.
RefSeqiWP_011480475.1. NC_007947.1.
YP_546362.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE50521; ABE50521; Mfla_2254.
GeneIDi3999810.
KEGGimfa:Mfla_2254.
PATRICi32270313. VBIMetFla97085_2367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000284 Genomic DNA. Translation: ABE50521.1 .
RefSeqi WP_011480475.1. NC_007947.1.
YP_546362.1. NC_007947.1.

3D structure databases

ProteinModelPortali Q1GZ16.
SMRi Q1GZ16. Positions 4-555.
ModBasei Search...

Protein-protein interaction databases

STRINGi 265072.Mfla_2254.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE50521 ; ABE50521 ; Mfla_2254 .
GeneIDi 3999810.
KEGGi mfa:Mfla_2254.
PATRICi 32270313. VBIMetFla97085_2367.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MFLA265072:GHWJ-2311-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT / ATCC 51484 / DSM 6875.

Entry informationi

Entry nameiFTHS_METFK
AccessioniPrimary (citable) accession number: Q1GZ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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