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Q1GZ16 (FTHS_METFK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Mfla_2254
OrganismMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) [Complete proteome] [HAMAP]
Taxonomic identifier265072 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293047

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1GZ16 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: 8C3936EB1B4889D0

FASTA55760,157
        10         20         30         40         50         60 
MFSDIEIARQ AKLRKISEIA AELGLNEDSI TLYGQYKAKI DLNANPQLQA QPDGKLILVT 

        70         80         90        100        110        120 
AISPSPAGEG KTTTTVGLGD ALQRMGKRAV ICLREPSMGP VFGMKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
DINLHFTGDF ASIALAHNLL AAMIDNHIHH GNALQIDPRQ VTWKRVIDMN DRALRQVVIG 

       190        200        210        220        230        240 
LGGKVNGQPR EDGFDIVVAS EVMAVFCLAD SLKDLRTRLG RIVVGYTYSG QPVTAQDLKA 

       250        260        270        280        290        300 
HGAMTVLLKD AIKPNLVQTL EHTPALLHGG PFANIAHGCN SVIATRTALK LGDYVVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF IDIKCRKAGL HPDACVIVAT IRALKYHGGA DVSALSREDM LALDRGIANL 

       370        380        390        400        410        420 
EKHVENVTTH YGMPAVIALN RFDHDTEAEL ALVMKRMGEM GIKVVVAEHW AKGGAGAESL 

       430        440        450        460        470        480 
AAHVLQLIEG RSEGVRYVYE SSETLWEKVN QVARKIYGAM DVHAPRPVRA MIDRLQDAGY 

       490        500        510        520        530        540 
GHYPICIAKT QYSFSTDASR RGVPHEHILT VRAVRLCAGA EFVVIICDDI MTMPGLPEEP 

       550 
CAIRMDIDDD GQVVGLY 

« Hide

References

[1]"Complete sequence of Methylobacillus flagellatus KT."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KT / ATCC 51484 / DSM 6875.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000284 Genomic DNA. Translation: ABE50521.1.
RefSeqYP_546362.1. NC_007947.1.

3D structure databases

ProteinModelPortalQ1GZ16.
SMRQ1GZ16. Positions 4-555.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING265072.Mfla_2254.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE50521; ABE50521; Mfla_2254.
GeneID3999810.
KEGGmfa:Mfla_2254.
PATRIC32270313. VBIMetFla97085_2367.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK2529725.

Enzyme and pathway databases

BioCycMFLA265072:GHWJ-2311-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_METFK
AccessionPrimary (citable) accession number: Q1GZ16
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 27, 2006
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways