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Q1GYR6

- RUVC_METFK

UniProt

Q1GYR6 - RUVC_METFK

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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene
ruvC, Mfla_2354
Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Magnesium By similarity
Metal bindingi74 – 741Magnesium By similarity
Metal bindingi146 – 1461Magnesium By similarity
Metal bindingi149 – 1491Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMFLA265072:GHWJ-2413-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:Mfla_2354
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
ProteomesiUP000002440: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Crossover junction endodeoxyribonuclease RuvCUniRule annotationPRO_0000332427Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_2354.

Structurei

3D structure databases

ProteinModelPortaliQ1GYR6.
SMRiQ1GYR6. Positions 5-163.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012181.
KOiK01159.
OMAiPDCAAIE.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiPS01321. RUVC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GYR6-1 [UniParc]FASTAAdd to Basket

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MTFRILGIDP GLRLTGFGVI EKTGEKLAYV ASGTIKTTTG KGSEIEDLPT    50
RLKIILDSLA EVIDNYQPQQ AAIEKVFVNV NPQSTLLLGQ ARGAAISALV 100
LQGLPIAEYT ALQVKQSVVG HGHAAKDQVQ EMVKRLLNLP GLPRPDSADA 150
LACAICHAHG GQGLGKLATA GFRVKGGRLI 180
Length:180
Mass (Da):18,958
Last modified:June 27, 2006 - v1
Checksum:i76041F822A09BC67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000284 Genomic DNA. Translation: ABE50621.1.
RefSeqiYP_546462.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE50621; ABE50621; Mfla_2354.
GeneIDi4001450.
KEGGimfa:Mfla_2354.
PATRICi32270523. VBIMetFla97085_2471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000284 Genomic DNA. Translation: ABE50621.1 .
RefSeqi YP_546462.1. NC_007947.1.

3D structure databases

ProteinModelPortali Q1GYR6.
SMRi Q1GYR6. Positions 5-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 265072.Mfla_2354.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE50621 ; ABE50621 ; Mfla_2354 .
GeneIDi 4001450.
KEGGi mfa:Mfla_2354.
PATRICi 32270523. VBIMetFla97085_2471.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012181.
KOi K01159.
OMAi PDCAAIE.
OrthoDBi EOG6RG044.

Enzyme and pathway databases

BioCyci MFLA265072:GHWJ-2413-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
PROSITEi PS01321. RUVC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT / ATCC 51484 / DSM 6875.

Entry informationi

Entry nameiRUVC_METFK
AccessioniPrimary (citable) accession number: Q1GYR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 27, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi