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Q1GXD2

- PNP_METFK

UniProt

Q1GXD2 - PNP_METFK

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi486 – 4861MagnesiumUniRule annotation
    Metal bindingi492 – 4921MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciMFLA265072:GHWJ-77-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Mfla_0071
    OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
    Taxonomic identifieri265072 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus
    ProteomesiUP000002440: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 714714Polyribonucleotide nucleotidyltransferasePRO_0000329712Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi265072.Mfla_0071.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GXD2.
    SMRiQ1GXD2. Positions 617-690.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini553 – 61260KHUniRule annotationAdd
    BLAST
    Domaini622 – 69069S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiHGNFKSN.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GXD2-1 [UniParc]FASTAAdd to Basket

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    MTAIKKTITY GQHELTLETG EIARQADGAV MVSYGDTVVL VSVVGKREVK    50
    EGQDFFPLTV DYQEKTYAAG KIPGGFFKRE GRPSEKETLT SRLIDRPLRP 100
    LFPEAFYNEV QVVATVMSSD PEIDADIPAI IGASAALAIS GIPFYGPIGA 150
    ARVGYINGEY VLNPTASQLK ETALDLVVAA TESAVLMVES EAKELPEDVM 200
    LGSVVYGHEQ MQIVISAINE LAAEVGKEPW DWAPPEPNTE LIAKVEALAG 250
    ADINEAYKIK SKSARSSKLD EIRSRVLGEL ITETTSTSEA NEIKSIFHNL 300
    EAKVVRSQIL NGEPRIDGRD TRTVRPISIR TGVLPRTHGS ALFTRGETQA 350
    LVVATLGTGR DEQIIDALQG EYADRFMLHY NMPPYATGET GRVGTPKRRE 400
    IGHGRLAKRA LLAVLPSQEE FGYTIRVVSE ITESNGSSSM ASVCGGCLSL 450
    LDAGVPLKAH VAGIAMGLIK EGNRVAVLTD ILGDEDHLGD MDFKVAGTES 500
    GITALQMDIK ITGITAEIMR VALSQAKEGR LHILGLMKEA VGEQPQELSE 550
    FAPRIITMKI NPEKIRDVIG KGGAVIRALT EETGTTIDIE EDGTIKIGCT 600
    SAEAGEEAKK RIEAITAEVE VGQVYDGTVL KLLDFGAIVS LLPGKDGLLH 650
    ISQIAHQRVN AVADFLKEGQ VVKVKVLEVD DKGRVRLSAK ALIEAPSAEA 700
    PEEPAVAATG ADQQ 714
    Length:714
    Mass (Da):76,634
    Last modified:June 27, 2006 - v1
    Checksum:iB66742F931E4FBEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE48342.1.
    RefSeqiYP_544183.1. NC_007947.1.

    Genome annotation databases

    EnsemblBacteriaiABE48342; ABE48342; Mfla_0071.
    GeneIDi3999090.
    KEGGimfa:Mfla_0071.
    PATRICi32265641. VBIMetFla97085_0072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000284 Genomic DNA. Translation: ABE48342.1 .
    RefSeqi YP_544183.1. NC_007947.1.

    3D structure databases

    ProteinModelPortali Q1GXD2.
    SMRi Q1GXD2. Positions 617-690.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265072.Mfla_0071.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE48342 ; ABE48342 ; Mfla_0071 .
    GeneIDi 3999090.
    KEGGi mfa:Mfla_0071.
    PATRICi 32265641. VBIMetFla97085_0072.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi HGNFKSN.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci MFLA265072:GHWJ-77-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT / ATCC 51484 / DSM 6875.

    Entry informationi

    Entry nameiPNP_METFK
    AccessioniPrimary (citable) accession number: Q1GXD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3