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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi486MagnesiumUniRule annotation1
Metal bindingi492MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Mfla_0071
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesMethylophilaceaeMethylobacillus
Proteomesi
  • UP000002440 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003297121 – 714Polyribonucleotide nucleotidyltransferaseAdd BLAST714

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_0071.

Structurei

3D structure databases

ProteinModelPortaliQ1GXD2.
SMRiQ1GXD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini553 – 612KHUniRule annotationAdd BLAST60
Domaini622 – 690S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GXD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAIKKTITY GQHELTLETG EIARQADGAV MVSYGDTVVL VSVVGKREVK
60 70 80 90 100
EGQDFFPLTV DYQEKTYAAG KIPGGFFKRE GRPSEKETLT SRLIDRPLRP
110 120 130 140 150
LFPEAFYNEV QVVATVMSSD PEIDADIPAI IGASAALAIS GIPFYGPIGA
160 170 180 190 200
ARVGYINGEY VLNPTASQLK ETALDLVVAA TESAVLMVES EAKELPEDVM
210 220 230 240 250
LGSVVYGHEQ MQIVISAINE LAAEVGKEPW DWAPPEPNTE LIAKVEALAG
260 270 280 290 300
ADINEAYKIK SKSARSSKLD EIRSRVLGEL ITETTSTSEA NEIKSIFHNL
310 320 330 340 350
EAKVVRSQIL NGEPRIDGRD TRTVRPISIR TGVLPRTHGS ALFTRGETQA
360 370 380 390 400
LVVATLGTGR DEQIIDALQG EYADRFMLHY NMPPYATGET GRVGTPKRRE
410 420 430 440 450
IGHGRLAKRA LLAVLPSQEE FGYTIRVVSE ITESNGSSSM ASVCGGCLSL
460 470 480 490 500
LDAGVPLKAH VAGIAMGLIK EGNRVAVLTD ILGDEDHLGD MDFKVAGTES
510 520 530 540 550
GITALQMDIK ITGITAEIMR VALSQAKEGR LHILGLMKEA VGEQPQELSE
560 570 580 590 600
FAPRIITMKI NPEKIRDVIG KGGAVIRALT EETGTTIDIE EDGTIKIGCT
610 620 630 640 650
SAEAGEEAKK RIEAITAEVE VGQVYDGTVL KLLDFGAIVS LLPGKDGLLH
660 670 680 690 700
ISQIAHQRVN AVADFLKEGQ VVKVKVLEVD DKGRVRLSAK ALIEAPSAEA
710
PEEPAVAATG ADQQ
Length:714
Mass (Da):76,634
Last modified:June 27, 2006 - v1
Checksum:iB66742F931E4FBEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA. Translation: ABE48342.1.
RefSeqiWP_011478439.1. NC_007947.1.

Genome annotation databases

EnsemblBacteriaiABE48342; ABE48342; Mfla_0071.
KEGGimfa:Mfla_0071.

Similar proteinsi

Entry informationi

Entry nameiPNP_METFK
AccessioniPrimary (citable) accession number: Q1GXD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 27, 2006
Last modified: August 30, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families