Reviewed, UniProtKB/Swiss-Prot Q1GXB4 (UBIC_METFK)

Names and origin

Protein names

Recommended name:
    Probable chorismate--pyruvate lyase
      Short name=CL
      Short name=CPL
    EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	Mfla_0053

Organism

Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) [Complete proteome] [HAMAP]

Taxonomic identifier

265072 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyruvate biosynthetic process Inferred from electronic annotation. Source: HAMAP ubiquinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000255909
Sites
	Binding site	67	1	Substrate By similarity
	Binding site	105	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1GXB4-1 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: 6A2375E044FB6C1A	FASTA	178	20,467
	10 20 30 40 50 60 MRDRWLKRAV GARHYRPWLT ERGSLTRRLQ QHSRQFAVQP LHLARKKPPL AEAQLLQVLP 70 80 90 100 110 120 RQHTLQRDVI LRCDGEAVVF AHSLLPQQAM RGTWRGLGRL GSHSLGSALF ADPRMCRGAL 130 140 150 160 170 QYKKLSPQHF LYRLAVAHIP AMRGPIWARR SVFRLGRKAV LVSELFLPSV LKLPLINK

References

[1]

"Complete sequence of Methylobacillus flagellatus KT." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. , Larimer F., Land M., Kyrpides N., Anderson I., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000284 Genomic DNA. Translation: ABE48324.1.
RefSeq	YP_544165.1.
3D structure databases
SMR	Q1GXB4. Positions 12-170.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1GXB4.
Genome annotation databases
GeneID	3999506.
GenomeReviews	Gene locus Mfla_0053 in contig CP000284_GR.
KEGG	mfa:Mfla_0053.
NMPDR	fig|265072.7.peg.56.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3161.
HOGENOM	HBG644467.
OMA	GTPYVAA.
Enzyme and pathway databases
BioCyc	MFLA265072:MFLA_0053-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_METFK

Accession

Primary (citable) accession number: Q1GXB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	June 27, 2006
Last modified:	January 19, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)