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Q1GXA9 (ARLY_METFK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Mfla_0038
OrganismMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) [Complete proteome] [HAMAP]
Taxonomic identifier265072 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus ›

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Argininosuccinate lyase HAMAP-Rule MF_00006
PRO_0000321443

Sequences

Sequence LengthMass (Da)Tools
Q1GXA9 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: 65CE4713104E2DBB

FASTA46851,863
        10         20         30         40         50         60 
MTEKSNHLNQ PSSKTWSGRF NEPVAELVKQ YTASVGFDYR LAEYDIQGSL AHARMLGAQG 

        70         80         90        100        110        120 
IISQDDVAQI EQGLGEIMDE IRNGEFAWLL DLEDVHLNIE KRLTDKIGDA GKRLHTGRSR 

       130        140        150        160        170        180 
NDQVATDIRL WLRSMVDDAL SRLRKLQASL VALAEQHADT VMPGFTHLQV AQPVTFGHHL 

       190        200        210        220        230        240 
LAYFEMLQRD AERLVDARKR INRLPLGAAA LAGTSYPIDR ERVAHELGFE AVCENSLDAV 

       250        260        270        280        290        300 
SDRDFAIEFT AAAALIMTHL SRLSEELILW SSPRFGFIDI ADRFCTGSSI MPQKKNPDVP 

       310        320        330        340        350        360 
ELVRGKTGRV NGHLVALLTL MKSQPLAYNK DNQEDKEPLF DTVDTLLVTL EIYADMLRGI 

       370        380        390        400        410        420 
KVNKDAMRLA AAEGFATATD LADYLVKKGM PFRDAHEVVA LAVRHAVEQG CDLADLSLSQ 

       430        440        450        460 
LQKFSPEIAE DVYGVLTLEG SLASRNHRGG TAPAQVREAL KRARALLG

« Hide

References

[1]"Complete sequence of Methylobacillus flagellatus KT."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KT / ATCC 51484 / DSM 6875.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000284 Genomic DNA. Translation: ABE48309.1.
RefSeqYP_544150.1. NC_007947.1.

3D structure databases

ProteinModelPortalQ1GXA9.
SMRQ1GXA9. Positions 26-468.
ModBaseSearch...

Protein-protein interaction databases

STRING265072.Mfla_0038.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE48309; ABE48309; Mfla_0038.
GeneID3999455.
KEGGmfa:Mfla_0038.
PATRIC32265565. VBIMetFla97085_0039.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHOG000242744.
KOK01755.
OMAKEGIFDA.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycMFLA265072:GHWJ-101-MONOMER.
UniPathwayUPA00068; UER00114.

Family and domain databases

Gene3D1.10.275.10. 1 hit.
HAMAPMF_00006. Arg_succ_lyase.
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERPTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. argH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_METFK
AccessionPrimary (citable) accession number: Q1GXA9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 27, 2006
Last modified: May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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