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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Sala_0249
OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Taxonomic identifieri317655 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
Proteomesi
  • UP000006578 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201691 – 306Methionyl-tRNA formyltransferaseAdd BLAST306

Interactioni

Protein-protein interaction databases

STRINGi317655.Sala_0249

Structurei

3D structure databases

ProteinModelPortaliQ1GWK0
SMRiQ1GWK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q1GWK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAFMGTPP FAVPTLAALH TAGHDIAAVY SQPPRPAQRG KKLQKSPVQL
60 70 80 90 100
WAEEHGLPVR TPKSLKSDEA QAEFAALDLD VAVVAAYGLI LPQAVLDAPR
110 120 130 140 150
EGCLNVHGSI LPRWRGAAPV QRAILAGDAE TGVTIMQMDA GLDTGAMRLI
160 170 180 190 200
ETTPVARKSA GLLTHELAEM GALMMRRVLS ELHAFPPVPQ PDEGVTYAAK
210 220 230 240 250
IDKSEARLDF LVSAVQVERQ VRAFNPAPGA FFELEGERYK VLAAEVVHPA
260 270 280 290 300
ETVAGAAPGV TIDDRLAIAC NPGAIRVTRI QRAGKPAMEA GEMLRGRGIA

KGTRLA
Length:306
Mass (Da):32,573
Last modified:June 27, 2006 - v1
Checksum:i0912F86D238A77E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000356 Genomic DNA Translation: ABF51972.1
RefSeqiWP_011540564.1, NC_008048.1

Genome annotation databases

EnsemblBacteriaiABF51972; ABF51972; Sala_0249
KEGGisal:Sala_0249

Similar proteinsi

Entry informationi

Entry nameiFMT_SPHAL
AccessioniPrimary (citable) accession number: Q1GWK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health