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Q1GVQ8

- PNP_SPHAL

UniProt

Q1GVQ8 - PNP_SPHAL

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi487 – 4871MagnesiumUniRule annotation
Metal bindingi493 – 4931MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSALA317655:GHHY-543-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Sala_0543
OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Taxonomic identifieri317655 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
ProteomesiUP000006578: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 771771Polyribonucleotide nucleotidyltransferasePRO_0000329860Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317655.Sala_0543.

Structurei

3D structure databases

ProteinModelPortaliQ1GVQ8.
SMRiQ1GVQ8. Positions 619-691.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini554 – 61360KHUniRule annotationAdd
BLAST
Domaini623 – 69169S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GVQ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFDVKKVSIE WGGETLTLET GKVARQADGA VIATLGETVV LCAVTAAKSV
60 70 80 90 100
KDGQDFFPLT VHYQEKYSAA GRIPGGFFKR ERGATEKETL VSRLIDRPIR
110 120 130 140 150
PLFPEGFYNE INAIAQVLSY DGHNEPDILA MVAASAALTI SGVPFMGPIG
160 170 180 190 200
AARVGYLNGE YILNPTDEQV AEGDLDLVVA ATHDAVMMVE SEANELSEEV
210 220 230 240 250
MLGAVLFAHD ACKEVVKAII KLAEQAAKEP WEIASSDDDA ALKDKLRKLI
260 270 280 290 300
GKDIAAAYKL TDKSARSNAL NEARAKAKES FIADGLDPQA VMAGIKIVKK
310 320 330 340 350
LEAEIVRTAI LKEGKRIDGR TTTQIRPIVA ETHFLPRAHG SALFTRGETQ
360 370 380 390 400
TIATCTLGTK DAEQMIDGLN GLSYQHFMLH YNFPPYSVGE VGRFGAPGRR
410 420 430 440 450
EVGHGKLAWR ALHPVLPSKD EFPYTIRLTS DITESNGSSS MASVCGGSLA
460 470 480 490 500
MMDAGVPIKR PVSGIAMGLI LEGKDYAILS DILGDEDHLG DMDFKVAGTS
510 520 530 540 550
EGITTMQMDI KIAGITREIF EAALAQAKEG RAHILGEMNK ALGEVRTELS
560 570 580 590 600
AHAPRIETMQ IDKAKIRDVI GTGGKVIREI VATTGAKVDI DDEGLIKISS
610 620 630 640 650
SDLDQIEAAR KWIAGIVEEA EVGKIYDGKV VNLVDFGAFV NFMGGKDGLV
660 670 680 690 700
HVSEIRNERV EKVADVLSEG QDVKVKVLEI DPRGKVRLSM RVVDQETGAE
710 720 730 740 750
LEDTRPAREP RERGDRGDRG DRGPRRDGGD RNRGGRERGP RRDGGGDRGP
760 770
RRERSEDGPE DQGHVPDFLK D
Length:771
Mass (Da):83,526
Last modified:June 27, 2006 - v1
Checksum:iC99458DE73F3E904
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000356 Genomic DNA. Translation: ABF52264.1.
RefSeqiYP_615597.1. NC_008048.1.

Genome annotation databases

EnsemblBacteriaiABF52264; ABF52264; Sala_0543.
GeneIDi4081433.
KEGGisal:Sala_0543.
PATRICi23690221. VBISphAla23391_0558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000356 Genomic DNA. Translation: ABF52264.1 .
RefSeqi YP_615597.1. NC_008048.1.

3D structure databases

ProteinModelPortali Q1GVQ8.
SMRi Q1GVQ8. Positions 619-691.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317655.Sala_0543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF52264 ; ABF52264 ; Sala_0543 .
GeneIDi 4081433.
KEGGi sal:Sala_0543.
PATRICi 23690221. VBISphAla23391_0558.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SALA317655:GHHY-543-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13593 / LMG 18877 / RB2256.

Entry informationi

Entry nameiPNP_SPHAL
AccessioniPrimary (citable) accession number: Q1GVQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 27, 2006
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3