Reviewed, UniProtKB/Swiss-Prot Q1GV29 (ASTD_SPHAL)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	Sala_0773

Organism

Sphingopyxis alaskensis (Sphingomonas alaskensis) [Complete proteome] [HAMAP]

Taxonomic identifier

117207 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Sphingopyxis

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_0000262430
Regions
	Nucleotide binding	206 – 211	6	NAD By similarity
Sites
	Active site	229	1	By similarity
	Active site	263	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1GV29-1 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: 23EA86C5C9C592C9	FASTA	481	51,361
	10 20 30 40 50 60 MSEELLSFEP ATGEQLWRGK VSDVDAEVEI ARRAWPEWAA KPVTFRTETL RRFADRVKAE 70 80 90 100 110 120 SEAFADLIAR ETGKPLWEAR TEVESVANKV DISVKAYAER TPNRRIEGAM GLRSAVRHKP 130 140 150 160 170 180 HGALAVLGPY NFPAHLPNGH IVPALIAGNS VVFKPSEKTP AVGAKLVELL HSAGVPQEVL 190 200 210 220 230 240 RLVVGGPDTG KALAAHPGID GLLFTGSART GLALNRQFAG QPGKMLALEM GGNNPIVAWD 250 260 270 280 290 300 TADIRTAAIL IVQSAFLSAG QRCSNARRLI VKDSLADALI AEVRELANRL IVDHPHADPA 310 320 330 340 350 360 PYMGPVIDNE AADGLTESFL VLMSNGGQVI RHMTRPVAGR PFLTPGIIDV TTMAERPDVE 370 380 390 400 410 420 LFGPLLQVIR VETFEAAIAE ANNTAFGLSA ALIGGTPQLY DQFWANARAG VINWNRPTNG 430 440 450 460 470 480 ASSAAPFGGV GLSGNHRPSA FYAADYCAYP VASAESDALR ASIGVGLRDP EGSQLVTKKY L

References

[1]

"Complete sequence of chromosome of Sphingopyxis alaskensis RB2256." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Chertkov O., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Cavicchioli R., Robb F., Ertan H., Schut F., Ting L.M., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000356 Genomic DNA. Translation: ABF52493.1.
RefSeq	YP_615826.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4080916.
GenomeReviews	Gene locus Sala_0773 in contig CP000356_GR.
KEGG	sal:Sala_0773.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1GV29.
Enzyme and pathway databases
BioCyc	SALA317655:SALA_0773-MON.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_SPHAL

Accession

Primary (citable) accession number: Q1GV29

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	June 27, 2006
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)