Q1GTU1 (G6PI_SPHAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Sala_1215

Organism

Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis) [Complete proteome] [HAMAP]

Taxonomic identifier

317655 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Sphingopyxis

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000252647
Sites
	Active site	333	1	Proton donor By similarity
	Active site	364	1	By similarity
	Active site	474	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1GTU1 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: 26281EBD752465AB	FASTA	501	53,610
	10 20 30 40 50 60 MTIASDAWQA LADWQPQKLT DLVAADPDAR LQALVRNVAD IRFDFAKTHL DAAAIAILAN 70 80 90 100 110 120 LAEAQDFGGR RKTLFSGGIA NPTENRAAEH SAERGDGAPE SVHAAQALHQ RMRMMIDAIE 130 140 150 160 170 180 AGAFGEIRHL LHIGIGGSAL GPDLLVDALG RHSDRYDVAV VSNVDGAALD EAFAKFSPEH 190 200 210 220 230 240 TLVAVASKTF TTTETLLNAN SALQWLDEAG VADPVGRFIA LTANPGRAME WGIDETRILP 250 260 270 280 290 300 FSETVGGRYS LWSSIGFPAA LALGWDAFAD LLEGAAEMDR HFRLADGADN ICLLAAFADQ 310 320 330 340 350 360 VYANRLGCQT RAVFAYDERL RLLPAYLQQL EMESNGKSVT LDGAPLAQHS APVTWGGVGT 370 380 390 400 410 420 DAQHAVFQLL HQGTHLVPVE FIVAREPDHL LDDAHHETLV ANCIAQGAAL MAGRASDDRA 430 440 450 460 470 480 RAYPGDRPST TILLDQVSPR SLGALIAFYE HRVFANAVLL GVNPFDQFGV ELGKEMAKGL 490 500 AEGTVDFDPA TQALMKAALG D

References

[1]

"Complete sequence of chromosome of Sphingopyxis alaskensis RB2256." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Chertkov O., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Cavicchioli R., Robb F., Ertan H., Schut F., Ting L.M., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13593 / LMG 18877 / RB2256.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000356 Genomic DNA. Translation: ABF52931.1.
RefSeq	YP_616264.1. NC_008048.1.
3D structure databases
ProteinModelPortal	Q1GTU1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4080439.
GenomeReviews	Gene locus Sala_1215 in contig CP000356_GR.
KEGG	sal:Sala_1215.
NMPDR	fig|317655.9.peg.1149.
PATRIC	23691623. VBISphAla23391_1251.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG352954.
OMA	ASIWDIN.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	SALA317655:SALA_1215-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_SPHAL

Accession

Primary (citable) accession number: Q1GTU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program